STRINGSTRING
H42K12.3 H42K12.3 npp-6 npp-6 spd-2 spd-2 F29B9.8 F29B9.8 ubc-9 ubc-9 rae-1 rae-1 npp-5 npp-5 npp-15 npp-15 npp-23 npp-23 npp-22 npp-22 npp-10 npp-10 npp-24 npp-24 npp-20 npp-20 npp-16 npp-16 npp-4 npp-4 npp-18 npp-18 npp-8 npp-8 npp-13 npp-13 npp-12 npp-12 npp-7 npp-7 npp-2 npp-2 ran-5 ran-5 npp-19 npp-19 smo-1 smo-1 npp-1 npp-1 K07F5.12 K07F5.12 uev-2 uev-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H42K12.3Uncharacterized protein. (522 aa)
npp-6Nuclear Pore complex Protein. (1562 aa)
spd-2Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. (824 aa)
F29B9.8Uncharacterized protein. (381 aa)
ubc-9SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
rae-1mRNA export factor rae-1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). It is specifically important for nuclear mRNA export. Has a role in neuronal development, where it acts downstream of rpm-1 to control axon termination and synapse formation in anterior lateral microtubule (ALM) and posterior lateral microtubule (PLM) mechanosensory neurons. Belo [...] (373 aa)
npp-5Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import. (813 aa)
npp-15Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. (1129 aa)
npp-23Nuclear Pore complex Protein. (371 aa)
npp-22Nucleoporin ndc-1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope; Belongs to the NDC1 family. (588 aa)
npp-10Nuclear pore complex protein Nup98-Nup96; Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase. Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes. Binds nos-2 mRNA, probably indirectly, and promotes its accu [...] (1678 aa)
npp-24Protein npp-24. (655 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa)
npp-16Nuclear Pore complex Protein. (497 aa)
npp-4Nuclear Pore complex Protein. (538 aa)
npp-18Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus. (363 aa)
npp-8Nuclear Pore complex Protein. (1340 aa)
npp-13Nuclear pore protein. (787 aa)
npp-12Nuclear Pore complex Protein. (1847 aa)
npp-7Nuclear Pore complex Protein. (1217 aa)
npp-2Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (598 aa)
ran-5RanBD1 domain-containing protein. (340 aa)
npp-19Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). Required for the proper organization of chromosomes on the mitotic spindle during anaphase. (381 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
npp-1Nup54 domain-containing protein. (639 aa)
K07F5.12Uncharacterized protein. (351 aa)
uev-2UBIQUITIN_CONJUGAT_2 domain-containing protein. (230 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (14%) [HD]