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let-60 | Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family. (184 aa) | ||||
rgs-9 | Regulator of G-protein signaling rgs-9. (235 aa) | ||||
abhd-12 | Hydrolase_4 domain-containing protein. (345 aa) | ||||
plc-2 | Phosphoinositide phospholipase C. (896 aa) | ||||
npr-22 | Neuropeptide receptor 22; Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior. Receptor for flp-7 which stimulates serotonin-induced fat loss. Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss. Acts in vitro as a receptor for the flp-7 FMRFamide- like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF- amide and SPMDRSKMVRF-amide. Also acts in vitro as a receptor for a number of other FMRFa [...] (434 aa) | ||||
rgs-8.2 | Regulator of G protein Signaling. (229 aa) | ||||
Y57G11C.43 | Uncharacterized protein. (302 aa) | ||||
npr-34 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (613 aa) | ||||
ral-1 | RAL (Ras-related GTPase) homolog. (254 aa) | ||||
ckr-2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (617 aa) | ||||
aap-1 | Phosphoinositide 3-kinase adapter subunit. (522 aa) | ||||
npr-14 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (342 aa) | ||||
ckr-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (421 aa) | ||||
esyt-2 | C2 domain-containing protein. (713 aa) | ||||
ntr-1 | Nematocin receptor 1; Receptor for nematocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The activity of this receptor may be modulated by ntr-2, leading to reduced intracellular cAMP production. Plays a role in gustatory associative learning. Also plays a role in male mating behavior ; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (379 aa) | ||||
rskn-1 | Putative ribosomal protein S6 kinase alpha-1; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1 ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (804 aa) | ||||
R12G8.1 | Uncharacterized protein. (164 aa) | ||||
M04F3.2 | Uncharacterized protein. (157 aa) | ||||
egl-30 | Heterotrimeric G protein alpha subunit. (355 aa) | ||||
nmur-2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (403 aa) | ||||
lpd-6 | Brix domain-containing protein. (573 aa) | ||||
dgk-5 | Putative diacylglycerol kinase K06A1.6. (1150 aa) | ||||
ser-3 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (610 aa) | ||||
gpc-1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa) | ||||
ser-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (683 aa) | ||||
pkc-1 | Protein kinase C-like 1B; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Involved in neuropeptide secretion in motor axons. Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in the signaling response to various sensory neurons; temperature, odor, taste, and osmolality. Its role in regulation differs depending on the neuron in which it is acting; thermosensation in AFD neurons, osmolality in ASH neuro [...] (763 aa) | ||||
rgs-7 | Regulator of G-protein signaling rgs-7; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunit egl-30 (G-alpha(q)), thereby driving it into its inactive GDP-bound form. May organize egl-30 into a stable multiprotein signaling complex, and thereby persistently inhibit egl-30 when triggered by calcium or phospholipids. (819 aa) | ||||
unc-73 | Guanine nucleotide exchange factor UNC-73A. (2488 aa) | ||||
dgk-3 | Probable diacylglycerol kinase 3; Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels. Belongs to the eukaryotic diacylglycerol kinase family. (795 aa) | ||||
gnrr-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (401 aa) | ||||
rgs-8.1 | RGS domain-containing protein. (229 aa) | ||||
gpb-2 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa) | ||||
F48G7.9 | Phorbol-ester/DAG-type domain-containing protein. (125 aa) | ||||
F48G7.10 | Uncharacterized protein. (168 aa) | ||||
dgk-2 | Diacylglycerol kinase. (536 aa) | ||||
rgs-10 | Regulator of G-protein signaling rgs-10; Shown to have a role in viability and embryogenesis. (270 aa) | ||||
rgs-11 | Regulator of G-protein signaling rgs-11. (274 aa) | ||||
mpk-1 | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] (444 aa) | ||||
dagl-2 | Lipase_3 domain-containing protein. (683 aa) | ||||
dgk-4 | Diacylglycerol kinase. (1339 aa) | ||||
eas-1 | Probable Golgi transport protein 1; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family. (141 aa) | ||||
rbf-1 | Rabphilin-1; Rab-3 effector. (1106 aa) | ||||
itr-1 | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa) | ||||
npr-33 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (399 aa) | ||||
F25H9.7 | Uncharacterized protein. (137 aa) | ||||
ntr-2 | Nematocin receptor 2; Not directly activated by nematocin. May modulate activity of the nematocin receptor ntr- 1, leading to reduced intracellular cAMP production. Plays a role in male mating behavior. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (398 aa) | ||||
gpb-1 | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa) | ||||
F09C12.2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (418 aa) | ||||
gpc-2 | G protein gamma domain-containing protein. (62 aa) | ||||
nmur-3 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (445 aa) | ||||
dop-4 | Dopamine receptor 4; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. (517 aa) | ||||
npr-35 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (381 aa) | ||||
tkr-2 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa) | ||||
nmur-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (400 aa) | ||||
tkr-1 | Probable G-protein coupled receptor tkr-1; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family. (406 aa) | ||||
trhr-1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (395 aa) | ||||
sem-5 | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] (228 aa) | ||||
cgef-1 | DH domain-containing protein. (1055 aa) | ||||
C12D5.10 | Uncharacterized protein. (357 aa) | ||||
str-130 | Seven TM Receptor. (338 aa) | ||||
dgk-1 | Diacylglycerol kinase. (952 aa) | ||||
mpk-2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (605 aa) | ||||
tpa-1 | Protein kinase C-like 1; Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp- 29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir- 1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in phary [...] (704 aa) | ||||
egl-8 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] (1512 aa) | ||||
tkr-3 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (400 aa) |