STRINGSTRING
abts-1 abts-1 abts-2 abts-2 aat-3 aat-3 F52H2.4 F52H2.4 aat-7 aat-7 slc-25A18.2 slc-25A18.2 F56A4.10 F56A4.10 F56A4.12 F56A4.12 F56C3.9 F56C3.9 pept-3 pept-3 nhx-5 nhx-5 abts-3 abts-3 nhx-6 nhx-6 F59A1.13 F59A1.13 skat-1 skat-1 H11E01.2 H11E01.2 kcc-2 kcc-2 slc-36.4 slc-36.4 kcc-3 kcc-3 pept-1 pept-1 K08C7.1 K08C7.1 glt-3 glt-3 pbo-4 pbo-4 vglu-2 vglu-2 vnut-1 vnut-1 slc-25A10 slc-25A10 K11G9.5 K11G9.5 sulp-4 sulp-4 sulp-5 sulp-5 M117.1 M117.1 M162.5 M162.5 R01B10.3 R01B10.3 R02F2.8 R02F2.8 abts-4 abts-4 srh-56 srh-56 glt-6 glt-6 R10D12.1 R10D12.1 kcc-1 kcc-1 T01H3.3 T01H3.3 T02B11.6 T02B11.6 T04B8.5 T04B8.5 T05H10.3 T05H10.3 vglu-3 vglu-3 slc-17.9 slc-17.9 aat-6 aat-6 aat-4 aat-4 T19D12.10 T19D12.10 T19D12.9 T19D12.9 unc-47 unc-47 glt-4 glt-4 T22F3.10 T22F3.10 T22F3.11 T22F3.11 T22F3.7 T22F3.7 T22F3.8 T22F3.8 slc-36.2 slc-36.2 T27D12.1 T27D12.1 slc-17.4 slc-17.4 T28H11.8 T28H11.8 sulp-6 sulp-6 glt-7 glt-7 W04C9.6 W04C9.6 sulp-7 sulp-7 pitr-6 pitr-6 srh-59 srh-59 srh-60 srh-60 ncx-1 ncx-1 Y15E3A.4 Y15E3A.4 Y18D10A.23 Y18D10A.23 nhx-8 nhx-8 Y19D10A.11 Y19D10A.11 Y19D10A.4 Y19D10A.4 Y19D10A.5 Y19D10A.5 Y19D10A.8 Y19D10A.8 Y32F6A.4 Y32F6A.4 ncx-5 ncx-5 nkcc-1 nkcc-1 slc-36.3 slc-36.3 Y43F4B.7 Y43F4B.7 srh-57 srh-57 srh-305 srh-305 Y4C6B.2 Y4C6B.2 Y4C6B.3 Y4C6B.3 Y4C6B.4 Y4C6B.4 Y51B9A.6 Y51B9A.6 Y51F10.4 Y51F10.4 glt-5 glt-5 aat-9 aat-9 Y59H11AR.4 Y59H11AR.4 ncx-10 ncx-10 ncx-3 ncx-3 sulp-8 sulp-8 eat-4 eat-4 slc-17.1 slc-17.1 ZK54.3 ZK54.3 ZK563.2 ZK563.2 slc-17.7 slc-17.7 nhx-9 nhx-9 ZK822.5 ZK822.5 B0454.6 B0454.6 nhx-1 nhx-1 pitr-4 pitr-4 B0303.11 B0303.11 pitr-3 pitr-3 pitr-2 pitr-2 ncx-4 ncx-4 aat-8 aat-8 aat-1 aat-1 atgp-1 atgp-1 slc-17.8 slc-17.8 F23F1.6 F23F1.6 slc-17.5 slc-17.5 F21D12.3 F21D12.3 F21C10.9 F21C10.9 slc-25A18.1 slc-25A18.1 F18H3.4 F18H3.4 sulp-2 sulp-2 nhx-4 nhx-4 slc-17.6 slc-17.6 F11A5.9 F11A5.9 F10E7.9 F10E7.9 F10C2.7 F10C2.7 pitr-5 pitr-5 aat-2 aat-2 D1046.4 D1046.4 slc-25A26 slc-25A26 aat-5 aat-5 sulp-1 sulp-1 slc-25A29 slc-25A29 nhx-3 nhx-3 C50D2.2 C50D2.2 pitr-1 pitr-1 slc-36.5 slc-36.5 ctns-1 ctns-1 C39E9.7 C39E9.7 atgp-2 atgp-2 slc-17.2 slc-17.2 C35A5.3 C35A5.3 C27D8.2 C27D8.2 ajm-1 ajm-1 C18H9.5 C18H9.5 C18D1.2 C18D1.2 ncx-9 ncx-9 ncx-8 ncx-8 glt-1 glt-1 ncx-2 ncx-2 ncx-6 ncx-6 ncx-7 ncx-7 pept-2 pept-2 slc-17.3 slc-17.3 C01B4.8 C01B4.8 C01B4.7 C01B4.7 nhx-2 nhx-2 F36G3.2 F36G3.2 F41C3.2 F41C3.2 sulp-3 sulp-3 F44E7.7 F44E7.7 cima-1 cima-1 F47B10.9 F47B10.9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
abts-1Anion exchange protein. (1215 aa)
abts-2Anion/Bicarbonate TranSporter family. (737 aa)
aat-3Amino Acid Transporter. (529 aa)
F52H2.4Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (486 aa)
aat-7Amino Acid Transporter. (500 aa)
slc-25A18.2SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
F56A4.10MFS domain-containing protein. (470 aa)
F56A4.12MFS domain-containing protein. (465 aa)
F56C3.9BTB domain-containing protein. (206 aa)
pept-3Peptide transporter 3; Neuron-specific, H(+)-coupled oligopeptide transporter with broad specificity towards di- and tripeptides in a Na(+) and Cl(-)- independent manner. Shows H(+) channel activity in the absence of peptide substrates; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (701 aa)
nhx-5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (630 aa)
abts-3HCO3_cotransp domain-containing protein. (1043 aa)
nhx-6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (634 aa)
F59A1.13MFS domain-containing protein. (494 aa)
skat-1Probable amino acid transporter skat-1; Plays a role in the accumulation of vital dyes and endogenous fluorescent compounds in lysosome related organelles. Has an effect on lysosome related organelle (LRO) function, in a pathway with serotonin. (460 aa)
H11E01.2MFS domain-containing protein. (458 aa)
kcc-2K+/Cl-Cotransporter. (1129 aa)
slc-36.4Aa_trans domain-containing protein. (481 aa)
kcc-3Potassium/chloride cotransporter 3; Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior. By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis. Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients. Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC. (1081 aa)
pept-1Peptide transporter family 1; Low-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine. Transport is independent of sodium and chloride ions. Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine. Regulates cellular pH differences together with the antiporter protein, nhx-2. Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently a [...] (835 aa)
K08C7.1Uncharacterized protein. (431 aa)
glt-3Putative sodium-dependent excitatory amino acid transporter glt-3. (532 aa)
pbo-4Na(+)/H(+) exchanger protein 7; Na+/H+ exchanger which mediates the transient acidification of the coelomic space and plays a role in contraction of posterior body muscles during defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. (783 aa)
vglu-2MFS domain-containing protein. (573 aa)
vnut-1MFS domain-containing protein. (445 aa)
slc-25A10Oxoglutarate/malate carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (290 aa)
K11G9.5MFS domain-containing protein. (460 aa)
sulp-4STAS domain-containing protein. (749 aa)
sulp-5STAS domain-containing protein. (737 aa)
M117.1MFS domain-containing protein. (523 aa)
M162.5MFS domain-containing protein. (487 aa)
R01B10.3SLC3A2_N domain-containing protein. (98 aa)
R02F2.8Aa_trans domain-containing protein. (494 aa)
abts-4Anion/Bicarbonate TranSporter family. (956 aa)
srh-56Serpentine Receptor, class H. (344 aa)
glt-6Putative sodium-dependent excitatory amino acid transporter glt-6. (542 aa)
R10D12.1MFS domain-containing protein. (485 aa)
kcc-1K+/Cl-Cotransporter. (1156 aa)
T01H3.3Uncharacterized protein. (616 aa)
T02B11.6MFS domain-containing protein. (471 aa)
T04B8.5Uncharacterized protein. (952 aa)
T05H10.3Uncharacterized protein T05H10.3. (158 aa)
vglu-3Potential vesicular glutamate transporter vglu-3. (544 aa)
slc-17.9MFS domain-containing protein. (516 aa)
aat-6Amino acid transporter protein 6; Amino acid transporter that mediates the uptake of the L- enantiomers of various amino acids, including L-glutamate (Probable). May play a role in promoting fertility. (523 aa)
aat-4Amino Acid Transporter. (526 aa)
T19D12.10MFS domain-containing protein. (455 aa)
T19D12.9MFS domain-containing protein. (462 aa)
unc-47Vesicular GABA transporter; Involved in the uptake of GABA into the synaptic vesicles. Belongs to the amino acid/polyamine transporter 2 family. (486 aa)
glt-4Putative sodium-dependent excitatory amino acid transporter glt-4; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D- aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. (499 aa)
T22F3.10MFS domain-containing protein. (453 aa)
T22F3.11MFS domain-containing protein. (453 aa)
T22F3.7MFS domain-containing protein. (453 aa)
T22F3.8MFS domain-containing protein. (482 aa)
slc-36.2Aa_trans domain-containing protein. (449 aa)
T27D12.1MFS domain-containing protein. (502 aa)
slc-17.4MFS domain-containing protein. (573 aa)
T28H11.8Uncharacterized protein. (465 aa)
sulp-6STAS domain-containing protein. (823 aa)
glt-7Amino acid transporter. (541 aa)
W04C9.6Uncharacterized protein. (459 aa)
sulp-7STAS domain-containing protein. (582 aa)
pitr-6Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (485 aa)
srh-59Serpentine Receptor, class H. (336 aa)
srh-60Serpentine Receptor, class H. (336 aa)
ncx-1Sodium-calcium exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (880 aa)
Y15E3A.4MFS domain-containing protein. (469 aa)
Y18D10A.23Aa_trans domain-containing protein. (503 aa)
nhx-8Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (681 aa)
Y19D10A.11annotation not available (465 aa)
Y19D10A.4annotation not available (475 aa)
Y19D10A.5annotation not available (478 aa)
Y19D10A.8annotation not available (458 aa)
Y32F6A.4Aa_trans domain-containing protein. (519 aa)
ncx-5Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (656 aa)
nkcc-1Na-K-Cl Cotransporter homolog. (1235 aa)
slc-36.3Aa_trans domain-containing protein. (454 aa)
Y43F4B.7Aa_trans domain-containing protein. (455 aa)
srh-57Serpentine Receptor, class H. (320 aa)
srh-305Serpentine Receptor, class H. (320 aa)
Y4C6B.2Aa_trans domain-containing protein. (484 aa)
Y4C6B.3MFS domain-containing protein. (459 aa)
Y4C6B.4MFS domain-containing protein. (458 aa)
Y51B9A.6MFS domain-containing protein. (516 aa)
Y51F10.4Aa_trans domain-containing protein. (598 aa)
glt-5Amino acid transporter. (491 aa)
aat-9Amino Acid Transporter. (541 aa)
Y59H11AR.4Aa_trans domain-containing protein. (465 aa)
ncx-10Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (668 aa)
ncx-3Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (830 aa)
sulp-8STAS domain-containing protein. (611 aa)
eat-4Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa)
slc-17.1MFS domain-containing protein. (479 aa)
ZK54.3Uncharacterized protein. (89 aa)
ZK563.2Uncharacterized protein. (573 aa)
slc-17.7MFS domain-containing protein. (506 aa)
nhx-9Probable Na(+)/H(+) antiporter nhx-9; Serves some physiological function other than regulation of cellular pH. (667 aa)
ZK822.5Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (577 aa)
B0454.6AA_permease_C domain-containing protein. (585 aa)
nhx-1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (514 aa)
pitr-4Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (523 aa)
B0303.11Uncharacterized amino-acid permease B0303.11. (927 aa)
pitr-3Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (494 aa)
pitr-2Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (494 aa)
ncx-4Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (596 aa)
aat-8Amino Acid Transporter. (483 aa)
aat-1Amino Acid Transporter. (493 aa)
atgp-1Aamy domain-containing protein. (613 aa)
slc-17.8MFS domain-containing protein. (527 aa)
F23F1.6AA_permease_C domain-containing protein. (583 aa)
slc-17.5MFS domain-containing protein. (530 aa)
F21D12.3Aa_trans domain-containing protein. (496 aa)
F21C10.9N-acetyltransferase domain-containing protein. (317 aa)
slc-25A18.1SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
F18H3.4Uncharacterized protein. (459 aa)
sulp-2STAS domain-containing protein. (652 aa)
nhx-4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (749 aa)
slc-17.6MFS domain-containing protein. (546 aa)
F11A5.9MFS domain-containing protein. (519 aa)
F10E7.9AA_permease domain-containing protein. (603 aa)
F10C2.7MFS domain-containing protein. (458 aa)
pitr-5Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (509 aa)
aat-2Amino Acid Transporter. (483 aa)
D1046.4Uncharacterized protein. (568 aa)
slc-25A26SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family. (269 aa)
aat-5Amino Acid Transporter. (537 aa)
sulp-1STAS domain-containing protein. (729 aa)
slc-25A29SLC (SoLute Carrier) homolog; Belongs to the mitochondrial carrier (TC 2.A.29) family. (360 aa)
nhx-3Probable Na(+)/H(+) antiporter nhx-3; Plays a role in epithelial membrane transport processes. (670 aa)
C50D2.2AA_permease_C domain-containing protein. (589 aa)
pitr-1Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (530 aa)
slc-36.5Aa_trans domain-containing protein. (489 aa)
ctns-1Cystinosin homolog; Thought to transport cystine out of lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells. (404 aa)
C39E9.7Uncharacterized protein. (498 aa)
atgp-2Aamy domain-containing protein. (647 aa)
slc-17.2Uncharacterized transporter slc-17.2. (493 aa)
C35A5.3MFS domain-containing protein. (460 aa)
C27D8.2BACK domain-containing protein. (500 aa)
ajm-1Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. (1905 aa)
C18H9.5MFS domain-containing protein. (464 aa)
C18D1.2MFS domain-containing protein. (478 aa)
ncx-9Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis (Probable). Required for patterning of neural circuits: functions in the same pathway as RAC- dependent effectors of the unc-6/netrin signaling pathway to set left/ right patterning of the VD/DD GABAergic circuit. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (701 aa)
ncx-8Na/Ca eXchangers; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (703 aa)
glt-1Excitatory amino acid transporter; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium (By similarity). (503 aa)
ncx-2Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (975 aa)
ncx-6Putative sodium/calcium exchanger 6. (590 aa)
ncx-7Putative sodium/calcium exchanger 7. (672 aa)
pept-2Peptide transporter family 2; Proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides. Transport is independent of sodium and chloride ions. Protein shows high affinity to peptide substrates. Belongs to the PTR2/POT transporter (TC 2.A.17) family. (785 aa)
slc-17.3Uncharacterized transporter slc-17.3. (535 aa)
C01B4.8MFS domain-containing protein. (478 aa)
C01B4.7MFS domain-containing protein. (475 aa)
nhx-2Na(+)/H(+) exchanger protein 2; Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis. Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept- 1. May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release. May play a role in the regulation of lifespan independent of the stress response pathway. (644 aa)
F36G3.2Uncharacterized protein F36G3.2; To the C-terminal of C.elegans F21C10.9. (313 aa)
F41C3.2Uncharacterized protein. (499 aa)
sulp-3Sulfate permease family protein 3; Possible sulfate transporter. (782 aa)
F44E7.7MFS domain-containing protein. (455 aa)
cima-1MFS domain-containing protein. (543 aa)
F47B10.9BTB domain-containing protein. (218 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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