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| | rbx-1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa) |
| | age-1 | Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1182 aa) |
| | jnk-1 | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] (463 aa) |
| | mpk-2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (605 aa) |
| | mapk-15 | Mitogen-activated protein kinase 15; Atypical MAPK protein. Regulates primary cilium formation in sensory neurons and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Acts in dopamine (DA) neurons to support synaptic membrane dat-1 availability via activation of rho-1 thereby sustaining normal levels of DA clearance. Plays a role in male mating behavior, probably in part through regulating the localization of the polycystin pkd-2. Functions postembryonically in the URX sensory neurons to constrain URX dendrite growth throughout lifetime, prob [...] (470 aa) |
| | madf-11 | MADF domain-containing protein. (516 aa) |
| | skr-17 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa) |
| | prk-1 | Protein kinase domain-containing protein. (589 aa) |
| | usp-14 | Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily. (489 aa) |
| | kxd-1 | KxDL domain-containing protein. (140 aa) |
| | sem-5 | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] (228 aa) |
| | C16A3.2 | Uncharacterized protein. (221 aa) |
| | C16D2.1 | Uncharacterized protein. (194 aa) |
| | rpn-2 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa) |
| | snb-5 | Synaptobrevin-like protein 5. (102 aa) |
| | rege-1 | Endoribonuclease rege-1; Endonuclease which binds to the 3'UTR of target mRNAs and induces degradation of the transcript. Negatively regulates the expression of the transcription factor ets-4, which probably controls the expression of lipid metabolism genes. May play a role in the clearance of apoptotic cell corpses. (634 aa) |
| | pas-4 | Proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (253 aa) |
| | lin-1 | ETS domain-containing protein. (441 aa) |
| | unc-60 | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa) |
| | skr-16 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa) |
| | mak-2 | MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (366 aa) |
| | tap-1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. (386 aa) |
| | C46H3.2 | Uncharacterized protein. (920 aa) |
| | pbs-2 | Proteasome subunit beta; Belongs to the peptidase T1B family. (277 aa) |
| | C49C3.10 | Protein kinase domain-containing protein. (384 aa) |
| | ets-8 | ETS domain-containing protein. (141 aa) |
| | skr-12 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) |
| | skr-9 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | skr-13 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) |
| | skr-8 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | C53D6.7 | Galectin. (311 aa) |
| | rskn-2 | Putative ribosomal protein S6 kinase alpha-2; Serine/threonine kinase that may play a role in mediating the mitogen- and stress-induced effects on transcription. May repress transcription via phosphorylation of 'Ser-1' of histone H2A. May phosphorylate histone H3 (By similarity). (773 aa) |
| | pas-6 | Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (260 aa) |
| | cul-1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa) |
| | F09C12.2 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (418 aa) |
| | ppfr-1 | Serine/threonine-protein phosphatase 4 regulatory subunit 1; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex. (1562 aa) |
| | peli-1 | PELI1 and PELI2 related. (458 aa) |
| | ubq-1 | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa) |
| | tli-1 | ToLlIp homolog. (243 aa) |
| | zag-1 | Zinc finger E-box-binding homeobox protein zag-1; Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Acts as a transcriptional repressor to regulate multiple, discrete, neuron- specific aspects of terminal differentiation, including cell migration, axonal development and gene expression. Required for axon guidance. Involved in the proper development of the pharynx. Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter. (596 aa) |
| | mltn-1 | MLt-TeN (Mlt-10) related. (709 aa) |
| | F34H10.1 | Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa) |
| | sek-5 | Protein kinase domain-containing protein. (360 aa) |
| | sek-4 | Protein kinase domain-containing protein. (364 aa) |
| | jkk-1 | Dual specificity mitogen-activated protein kinase kinase jkk-1; Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy meta [...] (435 aa) |
| | let-92 | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] (318 aa) |
| | soc-1 | Multisubstrate adapter protein soc-1; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole and gamma- aminobutyric acid (GABA)receptor-mediated sensitivity to muscimol. Regulates synaptic levels of nAchR receptor subunit lev-1 and unc-38, and GABA receptor subunit unc-49 in the nerve cord, probably downstream of egl-15. Regulates motility. During the [...] (430 aa) |
| | mkk-4 | MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (363 aa) |
| | mpk-1 | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] (444 aa) |
| | skr-3 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa) |
| | prk-2 | Serine/threonine-protein kinase prk-2; Involved in the negative regulation of synaptic differentiation in PLM neurons; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. PIM subfamily. (441 aa) |
| | skr-2 | SKp1 Related (Ubiquitin ligase complex component). (174 aa) |
| | skr-1 | Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa) |
| | F46C5.6 | Uncharacterized protein. (945 aa) |
| | skr-5 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa) |
| | paa-1 | Probable serine/threonine-protein phosphatase PP2A regulatory subunit; Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase sign [...] (590 aa) |
| | kbrl-1 | NF-kappa-B inhibitor-interacting Ras-like protein; Atypical Ras-like protein that may act as a regulator of NF- kappa-B activity. (364 aa) |
| | F52C6.2 | Ubiquitin-like domain-containing protein. (228 aa) |
| | F52C6.3 | Ubiquitin-like domain-containing protein. (197 aa) |
| | mom-4 | Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (536 aa) |
| | unc-60-2 | Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa) |
| | skr-15 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa) |
| | unc-64 | Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa) |
| | skr-18 | Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa) |
| | rpt-5 | 26S protease regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA [...] (430 aa) |
| | ptp-2 | Tyrosine-protein phosphatase non-receptor type ptp-2; Involved in embryonic and larval development. Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15. Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1. Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23. N [...] (668 aa) |
| | ubl-1 | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa) |
| | pbs-5 | Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...] (284 aa) |
| | K05F1.13 | C2H2-type domain-containing protein. (192 aa) |
| | mek-1 | Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] (347 aa) |
| | K08C9.7 | Uncharacterized protein. (154 aa) |
| | cul-6 | Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa) |
| | skr-21 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (176 aa) |
| | pik-1 | Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. (485 aa) |
| | lin-23 | F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). (667 aa) |
| | K11H12.9 | Protein kinase domain-containing protein. (378 aa) |
| | sek-1 | Dual specificity mitogen-activated protein kinase kinase sek-1; Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir- 1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive [...] (336 aa) |
| | rpn-8 | MPN domain-containing protein. (362 aa) |
| | skr-19 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa) |
| | skr-20 | SKp1 Related (Ubiquitin ligase complex component). (173 aa) |
| | zak-1 | SAM domain-containing protein. (745 aa) |
| | R155.3 | Protein-tyrosine-phosphatase. (1165 aa) |
| | rskn-1 | Putative ribosomal protein S6 kinase alpha-1; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1 ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (804 aa) |
| | enpl-1 | Endoplasmin homolog; Molecular chaperone that functions in the processing and transport of secreted proteins; Belongs to the heat shock protein 90 family. (760 aa) |
| | kgb-1 | GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] (390 aa) |
| | T12D8.10 | Uncharacterized protein; Belongs to the BolA/IbaG family. (98 aa) |
| | snb-6 | V-SNARE coiled-coil homology domain-containing protein. (102 aa) |
| | T22C1.6 | Uncharacterized protein. (335 aa) |
| | jun-1 | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. (319 aa) |
| | sqst-3 | ZZ-type domain-containing protein. (229 aa) |
| | sos-1 | Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa) |
| | sek-6 | Protein kinase domain-containing protein. (359 aa) |
| | mltn-3 | MLt-TeN (Mlt-10) related. (743 aa) |
| | mltn-5 | MLt-TeN (Mlt-10) related. (738 aa) |
| | lec-1 | 32 kDa beta-galactoside-binding lectin; Binds galactose. (285 aa) |
| | Y105C5A.24 | Protein kinase domain-containing protein. (478 aa) |
| | skr-10 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa) |
| | Y105E8A.11 | Uncharacterized protein; Belongs to the BolA/IbaG family. (106 aa) |
| | Y106G6A.1 | Protein kinase domain-containing protein. (430 aa) |
| | dsbn-1 | Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the dysbindin family. (210 aa) |
| | aap-1 | Phosphoinositide 3-kinase adapter subunit. (522 aa) |
| | sri-18 | Serpentine Receptor, class I. (346 aa) |
| | ric-4 | Synaptosomal-associated protein; Belongs to the SNAP-25 family. (234 aa) |
| | sqst-4 | ZZ-type domain-containing protein. (177 aa) |
| | Y34B4A.4 | Uncharacterized protein. (877 aa) |
| | skr-6 | SKp1 Related (Ubiquitin ligase complex component). (106 aa) |
| | crh-1 | BZIP domain-containing protein. (428 aa) |
| | ced-2 | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). (279 aa) |
| | skr-7 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | skr-14 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa) |
| | Y51B9A.9 | Protein kinase domain-containing protein. (381 aa) |
| | sta-1 | Signal transducer and activator of transcription 1; Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor. (706 aa) |
| | Y53C10A.5 | TMEM189_B_dmain domain-containing protein. (319 aa) |
| | Y53H1C.3 | WSN domain-containing protein. (739 aa) |
| | ubc-13 | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa) |
| | skr-4 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa) |
| | elk-2 | ELK transcription factor homolog. (310 aa) |
| | kgb-2 | Mitogen-activated protein kinase. (332 aa) |
| | sek-3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa) |
| | ubq-2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa) |
| | snb-7 | V-SNARE coiled-coil homology domain-containing protein. (102 aa) |
