node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C16D2.1 | C49C3.10 | C16D2.1a.1 | C49C3.10a.1 | Uncharacterized protein. | Protein kinase domain-containing protein. | 0.562 |
C16D2.1 | Y51B9A.9 | C16D2.1a.1 | Y51B9A.9.1 | Uncharacterized protein. | Protein kinase domain-containing protein. | 0.562 |
C16D2.1 | jnk-1 | C16D2.1a.1 | B0478.1a.1 | Uncharacterized protein. | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | 0.562 |
C16D2.1 | kgb-1 | C16D2.1a.1 | T07A9.3.1 | Uncharacterized protein. | GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] | 0.562 |
C16D2.1 | kgb-2 | C16D2.1a.1 | ZC416.4.1 | Uncharacterized protein. | Mitogen-activated protein kinase. | 0.562 |
C49C3.10 | C16D2.1 | C49C3.10a.1 | C16D2.1a.1 | Protein kinase domain-containing protein. | Uncharacterized protein. | 0.562 |
C49C3.10 | Y51B9A.9 | C49C3.10a.1 | Y51B9A.9.1 | Protein kinase domain-containing protein. | Protein kinase domain-containing protein. | 0.457 |
C49C3.10 | jun-1 | C49C3.10a.1 | T24H10.7a.1 | Protein kinase domain-containing protein. | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. | 0.562 |
Y51B9A.9 | C16D2.1 | Y51B9A.9.1 | C16D2.1a.1 | Protein kinase domain-containing protein. | Uncharacterized protein. | 0.562 |
Y51B9A.9 | C49C3.10 | Y51B9A.9.1 | C49C3.10a.1 | Protein kinase domain-containing protein. | Protein kinase domain-containing protein. | 0.457 |
Y51B9A.9 | jun-1 | Y51B9A.9.1 | T24H10.7a.1 | Protein kinase domain-containing protein. | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. | 0.562 |
Y51B9A.9 | kgb-2 | Y51B9A.9.1 | ZC416.4.1 | Protein kinase domain-containing protein. | Mitogen-activated protein kinase. | 0.479 |
jnk-1 | C16D2.1 | B0478.1a.1 | C16D2.1a.1 | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | Uncharacterized protein. | 0.562 |
jnk-1 | jun-1 | B0478.1a.1 | T24H10.7a.1 | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. | 0.776 |
jnk-1 | kgb-1 | B0478.1a.1 | T07A9.3.1 | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] | 0.911 |
jnk-1 | kgb-2 | B0478.1a.1 | ZC416.4.1 | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | Mitogen-activated protein kinase. | 0.909 |
jun-1 | C49C3.10 | T24H10.7a.1 | C49C3.10a.1 | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. | Protein kinase domain-containing protein. | 0.562 |
jun-1 | Y51B9A.9 | T24H10.7a.1 | Y51B9A.9.1 | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. | Protein kinase domain-containing protein. | 0.562 |
jun-1 | jnk-1 | T24H10.7a.1 | B0478.1a.1 | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] | 0.776 |
jun-1 | kgb-1 | T24H10.7a.1 | T07A9.3.1 | Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. | GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] | 0.944 |