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| | T26A5.8 | CBFD_NFYB_HMF domain-containing protein. (137 aa) |
| | rpn-10 | 26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex de [...] (346 aa) |
| | pbs-6 | Proteasome subunit beta type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (258 aa) |
| | madf-11 | MADF domain-containing protein. (516 aa) |
| | skr-17 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa) |
| | cks-1 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (By similarity). Has a role in the exit from M phase during early mitotic cell division. More specifically, thought to act by degrading B-type cyclins that causes breakdown of nuclear envelope and exit mitosis; Belongs to the CKS family. (94 aa) |
| | C10G11.8 | AAA domain-containing protein; Belongs to the AAA ATPase family. (438 aa) |
| | akt-1 | Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] (546 aa) |
| | kxd-1 | KxDL domain-containing protein. (140 aa) |
| | pas-1 | Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (246 aa) |
| | rpn-2 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa) |
| | rsa-1 | Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1; Regulatory subunit of phosphatase let-92 which recruits let- 92/paa-1 complex to the centrosomes, thereby regulating microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules. (404 aa) |
| | mcm-3 | MCM domain-containing protein; Belongs to the MCM family. (812 aa) |
| | rpn-3 | 26S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (504 aa) |
| | lin-35 | Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...] (961 aa) |
| | C34F6.10 | Uncharacterized protein. (1465 aa) |
| | cdc-7 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (411 aa) |
| | cye-1 | G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of [...] (524 aa) |
| | skr-16 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa) |
| | cdc-6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (518 aa) |
| | psmd-9 | Probable 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC); Belongs to the proteasome subunit p27 family. (197 aa) |
| | pbs-2 | Proteasome subunit beta; Belongs to the peptidase T1B family. (277 aa) |
| | skr-12 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) |
| | skr-9 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | skr-13 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) |
| | skr-8 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | rpt-1 | 26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (435 aa) |
| | pas-6 | Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (260 aa) |
| | pas-2 | Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (231 aa) |
| | cul-1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa) |
| | pole-2 | Probable DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (521 aa) |
| | F08F1.9 | CYCLIN domain-containing protein; Belongs to the cyclin family. (130 aa) |
| | rpn-5 | PCI domain-containing protein. (490 aa) |
| | ppfr-1 | Serine/threonine-protein phosphatase 4 regulatory subunit 1; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex. (1562 aa) |
| | rpa-1 | Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa) |
| | rpt-4 | Probable 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (406 aa) |
| | rpt-3 | Probable 26S proteasome regulatory subunit 6B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (414 aa) |
| | ubq-1 | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa) |
| | pas-5 | Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (248 aa) |
| | sur-6 | Serine/threonine-protein phosphatase 2A regulatory subunit sur-6; Probable regulatory subunit of serine/threonine phosphatase let-92. Together with let-92 and constant regulatory subunit paa-1, positively regulates centriole duplication during early embryonic cell divisions by preventing the degradation of sas-5 and kinase zyg-1. In addition, during vulva development, may play a role with phosphatase let-92 and regulatory subunit paa-1 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase signaling, probably by promoting lin-45 activation. In intesti [...] (495 aa) |
| | akt-2 | Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] (528 aa) |
| | rpt-2 | Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1. (443 aa) |
| | mcm-7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (730 aa) |
| | pole-1 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2144 aa) |
| | evl-18 | Uncharacterized protein. (574 aa) |
| | F34D10.9 | Uncharacterized protein. (487 aa) |
| | F34H10.1 | Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa) |
| | F35G12.12 | Uncharacterized protein. (491 aa) |
| | F37A4.5 | Uncharacterized protein F37A4.5; Belongs to the peptidase M67A family. (319 aa) |
| | let-92 | Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...] (318 aa) |
| | pbs-7 | Proteasome subunit beta; Belongs to the peptidase T1B family. (236 aa) |
| | F43B10.1 | Uncharacterized protein. (1325 aa) |
| | skr-3 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa) |
| | skr-2 | SKp1 Related (Ubiquitin ligase complex component). (174 aa) |
| | skr-1 | Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa) |
| | F46B6.10 | Uncharacterized protein. (127 aa) |
| | F46C5.6 | Uncharacterized protein. (945 aa) |
| | skr-5 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa) |
| | paa-1 | Probable serine/threonine-protein phosphatase PP2A regulatory subunit; Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase sign [...] (590 aa) |
| | skpt-1 | F-box domain-containing protein. (421 aa) |
| | rpn-7 | 26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (410 aa) |
| | F52C6.2 | Ubiquitin-like domain-containing protein. (228 aa) |
| | F52C6.3 | Ubiquitin-like domain-containing protein. (197 aa) |
| | mnat-1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (310 aa) |
| | skr-15 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa) |
| | skr-18 | Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa) |
| | F56F11.4 | AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa) |
| | rpt-5 | 26S protease regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA [...] (430 aa) |
| | rpn-6.1 | Probable 26S proteasome regulatory subunit rpn-6.1; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan. (438 aa) |
| | pri-1 | DNA primase small subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (410 aa) |
| | rpn-6.2 | Probable 26S proteasome regulatory subunit rpn-6.2; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity). (416 aa) |
| | orc-2 | Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (430 aa) |
| | cya-2 | CYCLIN domain-containing protein; Belongs to the cyclin family. (123 aa) |
| | ubl-1 | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa) |
| | lin-54 | Protein lin-54; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription; Belongs to the lin-54 family. (435 aa) |
| | pbs-5 | Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...] (284 aa) |
| | rpn-11 | 26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). (312 aa) |
| | sdz-24 | OB domain-containing protein. (236 aa) |
| | K08C9.7 | Uncharacterized protein. (154 aa) |
| | pbs-1 | Proteasome subunit beta. (242 aa) |
| | cul-6 | Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa) |
| | skr-21 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (176 aa) |
| | div-1 | DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Required for the distribution of pie-1 in cell divsion. (581 aa) |
| | R03H10.6 | REPA_OB_2 domain-containing protein. (324 aa) |
| | R03H10.7 | REPA_OB_2 domain-containing protein. (359 aa) |
| | mcm-5 | DNA replication licensing factor mcm-5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (759 aa) |
| | rpn-8 | MPN domain-containing protein. (362 aa) |
| | skr-19 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa) |
| | skr-20 | SKp1 Related (Ubiquitin ligase complex component). (173 aa) |
| | mbk-1 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1; Possible role in the function of olfactory neurons. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (882 aa) |
| | cki-1 | Cyclin-dependent kinase inhibitor 1; Negative cell-cycle regulator that functions at the G1-to-S- phase transition. Required for suspension of the cell cycle in dauer larvae and starved L1 larvae. In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage. Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation. Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa. Belongs to the CDI family. (184 aa) |
| | cki-2 | CKI family (Cyclin-dependent Kinase Inhibitor). (259 aa) |
| | rpn-9 | PCI domain-containing protein. (387 aa) |
| | pbs-4 | Proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (202 aa) |
| | T22D1.5 | Uncharacterized protein. (391 aa) |
| | rpn-1 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (981 aa) |
| | dpl-1 | Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...] (598 aa) |
| | T24C4.5 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (318 aa) |
| | dnj-23 | J domain-containing protein. (242 aa) |
| | pri-2 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. (503 aa) |
| | W05G11.2 | Cyclin N-terminal domain-containing protein. (192 aa) |
| | efl-1 | E2F_TDP domain-containing protein; Belongs to the E2F/DP family. (342 aa) |
| | skr-10 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa) |
| | pas-3 | Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (250 aa) |
| | mcm-2 | DNA helicase; Belongs to the MCM family. (881 aa) |
| | skr-6 | SKp1 Related (Ubiquitin ligase complex component). (106 aa) |
| | pbs-3 | Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (204 aa) |
| | cyd-1 | G1/S-specific cyclin-D; In association with cdk-4, regulates the progression through the G1 phase of the cell cycle during postembryonic development. Regulates proliferation of the coelomocyte lineage and intestinal cells during late embryogenesis. In complex with cdk-4, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP). (405 aa) |
| | orc-1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (636 aa) |
| | orc-4 | ORC (Origin Recognition Complex) subunit. (387 aa) |
| | mcm-4 | DNA replication licensing factor mcm-4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (823 aa) |
| | mcm-10 | Mcm10 domain-containing protein. (691 aa) |
| | pola-1 | DNA polymerase. (1456 aa) |
| | skr-7 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) |
| | skr-14 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa) |
| | efl-2 | E2F_TDP domain-containing protein. (412 aa) |
| | rpt-6 | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases assoc [...] (416 aa) |
| | cyh-1 | CYclin H. (332 aa) |
| | Y53F4B.3 | CBFD_NFYB_HMF domain-containing protein. (179 aa) |
| | cdt-1 | CDT1 domain-containing protein. (684 aa) |
| | skr-4 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa) |
| | Y66D12A.9 | Uncharacterized protein. (248 aa) |
| | Y71F9B.6 | Cyclin N-terminal domain-containing protein. (534 aa) |
| | Y71G12B.27 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (118 aa) |
| | orc-5 | ORC (Origin Recognition Complex) subunit. (396 aa) |
| | ubq-2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa) |
| | rpn-12 | 26S proteasome non-ATPase regulatory subunit 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (250 aa) |
| | cya-1 | G2/mitotic-specific cyclin-A1; Involved in the control of the cell cycle after S phase. May bind to and activate cdk-1 and/or cdk-2 to promote cell cycle progression. Necessary for embryogenesis. Belongs to the cyclin family. Cyclin AB subfamily. (485 aa) |
| | lin-52 | Protein lin-52; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis. Belongs to the lin-52 family. (161 aa) |
| | mcm-6 | DNA replication licensing factor mcm-6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...] (810 aa) |
| | lin-9 | Protein lin-9; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. (644 aa) |
| | ZK678.3 | annotation not available (163 aa) |
| | pas-7 | Proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (250 aa) |
