STRINGSTRING
his-46 his-46 npp-22 npp-22 B0545.4 B0545.4 npp-14 npp-14 npp-23 npp-23 C10A4.1 C10A4.1 npp-15 npp-15 his-37 his-37 C53D6.6 C53D6.6 npp-5 npp-5 his-50 his-50 rae-1 rae-1 his-31 his-31 his-64 his-64 ubc-9 ubc-9 F29B9.8 F29B9.8 spd-2 spd-2 sdz-19 sdz-19 his-5 his-5 F46F2.4 F46F2.4 his-56 his-56 his-60 his-60 npp-6 npp-6 uev-2 uev-2 H42K12.3 H42K12.3 his-38 his-38 his-18 his-18 his-28 his-28 K07F5.12 K07F5.12 npp-1 npp-1 K09A11.1 K09A11.1 smo-1 smo-1 npp-3 npp-3 npp-19 npp-19 npp-2 npp-2 T04A8.8 T04A8.8 his-1 his-1 npp-7 npp-7 his-67 his-67 npp-12 npp-12 npp-13 npp-13 npp-8 npp-8 npp-18 npp-18 npp-4 npp-4 npp-16 npp-16 npp-20 npp-20 dve-1 dve-1 his-26 his-26 his-10 his-10 his-14 his-14 npp-24 npp-24 npp-10 npp-10 lin-15B lin-15B ZK662.5 ZK662.5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
npp-22Nucleoporin ndc-1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope; Belongs to the NDC1 family. (588 aa)
B0545.4Dimer_Tnp_hAT domain-containing protein. (117 aa)
npp-14Nuclear pore complex protein 14; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity). Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4. (1390 aa)
npp-23Nuclear Pore complex Protein. (371 aa)
C10A4.1Dimer_Tnp_hAT domain-containing protein. (626 aa)
npp-15Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. (1129 aa)
his-37Histone H4. (103 aa)
C53D6.6Dimer_Tnp_hAT domain-containing protein. (615 aa)
npp-5Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import. (813 aa)
his-50Histone H4. (103 aa)
rae-1mRNA export factor rae-1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). It is specifically important for nuclear mRNA export. Has a role in neuronal development, where it acts downstream of rpm-1 to control axon termination and synapse formation in anterior lateral microtubule (ALM) and posterior lateral microtubule (PLM) mechanosensory neurons. Belo [...] (373 aa)
his-31Histone H4. (103 aa)
his-64Histone H4. (103 aa)
ubc-9SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
F29B9.8Uncharacterized protein. (381 aa)
spd-2Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. (824 aa)
sdz-19SKN-1 Dependent Zygotic transcript. (139 aa)
his-5Histone H4. (103 aa)
F46F2.4annotation not available (364 aa)
his-56Histone H4. (103 aa)
his-60Histone H4. (103 aa)
npp-6Nuclear Pore complex Protein. (1562 aa)
uev-2UBIQUITIN_CONJUGAT_2 domain-containing protein. (230 aa)
H42K12.3Uncharacterized protein. (522 aa)
his-38Histone H4. (103 aa)
his-18Histone H4. (103 aa)
his-28Histone H4. (103 aa)
K07F5.12Uncharacterized protein. (351 aa)
npp-1Nup54 domain-containing protein. (639 aa)
K09A11.1BED-type domain-containing protein. (605 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
npp-3Nuclear Pore complex Protein. (1696 aa)
npp-19Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). Required for the proper organization of chromosomes on the mitotic spindle during anaphase. (381 aa)
npp-2Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (598 aa)
T04A8.8Rad60-SLD domain-containing protein. (328 aa)
his-1Histone H4. (103 aa)
npp-7Nuclear Pore complex Protein. (1217 aa)
his-67Histone H4. (103 aa)
npp-12Nuclear Pore complex Protein. (1847 aa)
npp-13Nuclear pore protein. (787 aa)
npp-8Nuclear Pore complex Protein. (1340 aa)
npp-18Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus. (363 aa)
npp-4Nuclear Pore complex Protein. (538 aa)
npp-16Nuclear Pore complex Protein. (497 aa)
npp-20Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa)
dve-1Homeobox domain-containing protein. (468 aa)
his-26Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-14Histone H4. (103 aa)
npp-24Protein npp-24. (655 aa)
npp-10Nuclear pore complex protein Nup98-Nup96; Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase. Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes. Binds nos-2 mRNA, probably indirectly, and promotes its accu [...] (1678 aa)
lin-15BProtein lin-15B; Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity. (1440 aa)
ZK662.5Uncharacterized protein. (598 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (22%) [HD]