STRINGSTRING
B0025.4 B0025.4 his-47 his-47 his-48 his-48 his-46 his-46 fbxa-152 fbxa-152 fbxa-153 fbxa-153 oac-1 oac-1 tag-342 tag-342 let-526 let-526 oac-2 oac-2 tsp-17 tsp-17 set-3 set-3 swsn-7 swsn-7 mes-6 mes-6 spr-4 spr-4 C16A11.3 C16A11.3 C16A11.4 C16A11.4 C16C10.4 C16C10.4 oac-4 oac-4 C17E4.6 C17E4.6 swsn-2.2 swsn-2.2 elpc-4 elpc-4 pbrm-1 pbrm-1 dcp-66 dcp-66 set-2 set-2 C28G1.4 C28G1.4 jmjd-3.3 jmjd-3.3 C30F12.4 C30F12.4 fbxa-167 fbxa-167 set-4 set-4 prmt-5 prmt-5 C35E7.5 C35E7.5 fbxa-172 fbxa-172 C41G11.1 C41G11.1 set-32 set-32 oac-59 oac-59 met-1 met-1 C43H6.4 C43H6.4 oac-11 oac-11 set-6 set-6 C49F5.3 C49F5.3 rps-2 rps-2 his-35 his-35 his-41 his-41 his-37 his-37 spr-1 spr-1 utx-1 utx-1 oac-12 oac-12 oac-13 oac-13 swsn-4 swsn-4 F02D10.6 F02D10.6 set-8 set-8 his-51 his-51 his-54 his-54 his-53 his-53 his-52 his-52 his-50 his-50 his-44 his-44 his-43 his-43 oac-15 oac-15 oac-16 oac-16 set-9 set-9 F17A2.16 F17A2.16 oac-17 oac-17 his-31 his-31 his-33 his-33 his-34 his-34 jmjd-3.1 jmjd-3.1 rbbp-5 rbbp-5 his-64 his-64 jmjd-3.2 jmjd-3.2 F23H11.2 F23H11.2 let-418 let-418 pax-3 pax-3 jmjd-1.2 jmjd-1.2 psr-1 psr-1 set-10 set-10 set-11 set-11 oac-19 oac-19 his-30 his-30 his-29 his-29 srr-3 srr-3 oac-21 oac-21 oac-22 oac-22 oac-23 oac-23 oac-24 oac-24 oac-25 oac-25 oac-26 oac-26 oac-27 oac-27 oac-28 oac-28 oac-29 oac-29 lin-49 lin-49 jmjd-1.1 jmjd-1.1 fbxa-143 fbxa-143 his-8 his-8 his-39 his-39 his-5 his-5 his-7 his-7 F46F5.8 F46F5.8 oac-30 oac-30 fbxa-185 fbxa-185 fbxa-189 fbxa-189 cwp-5 cwp-5 str-79 str-79 dro-1 dro-1 sumv-2 sumv-2 his-56 his-56 his-58 his-58 his-57 his-57 dot-1.2 dot-1.2 his-61 his-61 his-60 his-60 his-62 his-62 dot-1.4 dot-1.4 oac-34 oac-34 oac-35 oac-35 oac-36 oac-36 scvp-1 scvp-1 his-66 his-66 his-65 his-65 H05L14.2 H05L14.2 oac-37 oac-37 his-38 his-38 K03B8.4 K03B8.4 mys-2 mys-2 his-18 his-18 his-19 his-19 his-22 his-22 his-28 his-28 his-21 his-21 his-20 his-20 rba-1 rba-1 lin-53 lin-53 phf-33 phf-33 oac-57 oac-57 oac-58 oac-58 set-12 set-12 set-13 set-13 hat-1 hat-1 oac-40 oac-40 oac-41 oac-41 bus-1 bus-1 met-2 met-2 mes-2 mes-2 set-14 set-14 lsy-12 lsy-12 snfc-5 snfc-5 set-15 set-15 amx-1 amx-1 oac-42 oac-42 lsd-1 lsd-1 oac-43 oac-43 oac-44 oac-44 oac-45 oac-45 his-4 his-4 his-3 his-3 his-1 his-1 lin-59 lin-59 chd-3 chd-3 set-18 set-18 T22B7.4 T22B7.4 ruvb-2 ruvb-2 prmt-9 prmt-9 his-67 his-67 his-68 his-68 oac-48 oac-48 jhdm-1 jhdm-1 set-1 set-1 str-81 str-81 oac-49 oac-49 srr-2 srr-2 lin-40 lin-40 jmjc-1 jmjc-1 mys-1 mys-1 set-19 set-19 set-20 set-20 hmg-20 hmg-20 oac-51 oac-51 oac-52 oac-52 dot-1.3 dot-1.3 prmt-7 prmt-7 mltn-11 mltn-11 W09B6.4 W09B6.4 Y102A11A.3 Y102A11A.3 Y104H12D.2 Y104H12D.2 Y104H12D.4 Y104H12D.4 ekl-4 ekl-4 set-33 set-33 arid-1 arid-1 elpc-1 elpc-1 Y113G7B.11 Y113G7B.11 prmt-1 prmt-1 swsn-1 swsn-1 Y14H12B.2 Y14H12B.2 ash-2 ash-2 Y17G9B.8 Y17G9B.8 set-21 set-21 mes-4 mes-4 cec-7 cec-7 mrg-1 mrg-1 dot-1.1 dot-1.1 Y39H10A.6 Y39H10A.6 spr-5 spr-5 set-23 set-23 Y43D4A.5 Y43D4A.5 set-25 set-25 Y44A6D.6 Y44A6D.6 fbxa-215 fbxa-215 jmjd-2 jmjd-2 ing-3 ing-3 set-26 set-26 phf-15 phf-15 oac-56 oac-56 swsn-3 swsn-3 set-27 set-27 Y73B3A.1 Y73B3A.1 Y73B3A.13 Y73B3A.13 fbxa-222 fbxa-222 rcor-1 rcor-1 Y75B12B.1 Y75B12B.1 Y75B8A.6 Y75B8A.6 tag-164 tag-164 Y9C9A.8 Y9C9A.8 ZC487.1 ZC487.1 dot-1.5 dot-1.5 set-30 set-30 ZK1127.3 ZK1127.3 ham-3 ham-3 htas-1 htas-1 his-26 his-26 his-16 his-16 his-10 his-10 his-11 his-11 his-12 his-12 his-14 his-14 his-15 his-15 rbr-2 rbr-2 swsn-6 swsn-6 elpc-3 elpc-3 dpy-30 dpy-30
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
B0025.4Uncharacterized protein. (148 aa)
his-47Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
fbxa-152F-box domain-containing protein. (378 aa)
fbxa-153F-box domain-containing protein. (378 aa)
oac-1Acyl_transf_3 domain-containing protein. (651 aa)
tag-342Uncharacterized protein. (348 aa)
let-526ARID domain-containing protein. (1768 aa)
oac-2Acyl_transf_3 domain-containing protein. (645 aa)
tsp-17Tetraspanin-17; Protects dopaminergic neurons against oxidative stress- induced neurodegeneration. May act partly via dopamine receptor dop-2 to negatively regulate dopamine reuptake transporter dat-1 activity. Also plays a role in modulating behaviors linked to dopamine signaling. Confers protection against oxidative stress in the whole body. (312 aa)
set-3SET domain-containing protein 3. (465 aa)
swsn-7SWI/SNF nucleosome remodeling complex component. (1244 aa)
mes-6Polycomb protein mes-6; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to ex [...] (459 aa)
spr-4Suppressor of presenilin protein 4; Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1. Might play a role in the oxidative stress response. (1311 aa)
C16A11.3SPK domain-containing protein. (299 aa)
C16A11.4SPK domain-containing protein. (527 aa)
C16C10.4Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. (166 aa)
oac-4Acyl_transf_3 domain-containing protein. (685 aa)
C17E4.6YL1_C domain-containing protein. (391 aa)
swsn-2.2SWIB domain-containing protein. (449 aa)
elpc-4Putative elongator complex protein 4; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the ELP4 family. (334 aa)
pbrm-1HMG box domain-containing protein. (1883 aa)
dcp-66Deacetylase Complex Protein. (724 aa)
set-2Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...] (1510 aa)
C28G1.4C2H2-type domain-containing protein. (1081 aa)
jmjd-3.3JmjC domain-containing protein. (753 aa)
C30F12.4Uncharacterized protein. (246 aa)
fbxa-167F-box domain-containing protein. (377 aa)
set-4Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway. (288 aa)
prmt-5Protein arginine N-methyltransferase 5; Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group. Plays a role in the negative regulation of DNA damage-induced apoptosis. By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell [...] (734 aa)
C35E7.5Uncharacterized protein. (1262 aa)
fbxa-172F-box domain-containing protein. (556 aa)
C41G11.1Metallophos domain-containing protein. (429 aa)
set-32SET domain-containing protein. (517 aa)
oac-59Acyl_transf_3 domain-containing protein. (698 aa)
met-1Histone-lysine N-methyltransferase. (1604 aa)
C43H6.4Uncharacterized protein. (627 aa)
oac-11Acyl_transf_3 domain-containing protein. (662 aa)
set-6SET domain-containing protein. (708 aa)
C49F5.3Uncharacterized protein. (258 aa)
rps-240S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (272 aa)
his-35Histone H2A; Belongs to the histone H2A family. (127 aa)
his-41Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-37Histone H4. (103 aa)
spr-1REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family. (558 aa)
utx-1UTX (Ubiquitously transcribed TPR on X) homolog. (1146 aa)
oac-12Acyl_transf_3 domain-containing protein. (643 aa)
oac-13Acyl_transf_3 domain-containing protein. (659 aa)
swsn-4SWI/SNF nucleosome remodeling complex component. (1474 aa)
F02D10.6Uncharacterized protein. (199 aa)
set-8SET domain-containing protein. (512 aa)
his-51Histone H2A. (127 aa)
his-54Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-53Histone H2A. (127 aa)
his-52Histone H2B 2. (123 aa)
his-50Histone H4. (103 aa)
his-44Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa)
his-43Histone H2A. (127 aa)
oac-15Acyl_transf_3 domain-containing protein. (659 aa)
oac-16Acyl_transf_3 domain-containing protein. (672 aa)
set-9Histone-lysine N-methyltransferase set-9; Histone methyltransferase (By similarity). Might play a role in transcriptional regulation. Together with set-26, negatively regulates lifespan in a germline-independent, partially daf- 16-dependent fashion. Together with set-26, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline ; Belongs to the class V-like SAM-binding methyltransferase superfamily. (1623 aa)
F17A2.16Uncharacterized protein. (322 aa)
oac-17Acyl_transf_3 domain-containing protein. (665 aa)
his-31Histone H4. (103 aa)
his-33Histone H2A. (127 aa)
his-34Histone H2B 1. (122 aa)
jmjd-3.1Lysine-specific demethylase jmjd-3.1; Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code. Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes. Required for gonad development and organization. Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. Acts cell- autonomously in Y-to-PDA tra [...] (1061 aa)
rbbp-5Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3. (454 aa)
his-64Histone H4. (103 aa)
jmjd-3.2JmjC domain-containing protein. (867 aa)
F23H11.2TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity). (865 aa)
let-418Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa)
pax-3PAX (Paired box) transcription factor. (308 aa)
jmjd-1.2Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. (929 aa)
psr-1Bifunctional arginine demethylase and lysyl-hydroxylase psr-1; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. (416 aa)
set-10MYND-type domain-containing protein. (430 aa)
set-11SET (Trithorax/polycomb) domain containing. (367 aa)
oac-19Acyl_transf_3 domain-containing protein. (698 aa)
his-30Histone H2A. (127 aa)
his-29Histone H2B 1. (122 aa)
srr-3Serpentine Receptor, class R. (381 aa)
oac-21Acyl_transf_3 domain-containing protein. (677 aa)
oac-22Acyl_transf_3 domain-containing protein. (686 aa)
oac-23Acyl_transf_3 domain-containing protein. (685 aa)
oac-24Acyl_transf_3 domain-containing protein. (650 aa)
oac-25Acyl_transf_3 domain-containing protein. (673 aa)
oac-26Acyl_transf_3 domain-containing protein. (682 aa)
oac-27Acyl_transf_3 domain-containing protein. (669 aa)
oac-28O-ACyltransferase homolog. (673 aa)
oac-29Acyl_transf_3 domain-containing protein. (658 aa)
lin-49Protein lin-49; Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1042 aa)
jmjd-1.1JmjC domain-containing protein. (548 aa)
fbxa-143F-box domain-containing protein. (371 aa)
his-8Histone H2B 2. (123 aa)
his-39Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
his-5Histone H4. (103 aa)
his-7Histone H2A. (127 aa)
F46F5.8Uncharacterized protein. (68 aa)
oac-30Acyl_transf_3 domain-containing protein. (647 aa)
fbxa-185F-box domain-containing protein. (554 aa)
fbxa-189F-box domain-containing protein. (569 aa)
cwp-5Coexpressed With Polycystins. (691 aa)
str-79Seven TM Receptor. (314 aa)
dro-1CBFD_NFYB_HMF domain-containing protein. (184 aa)
sumv-2Protein sumv-2; Influences the activity of genes involved in vulval development. (1145 aa)
his-56Histone H4. (103 aa)
his-58Probable histone H2B 4. (123 aa)
his-57Histone H2A; Belongs to the histone H2A family. (147 aa)
dot-1.2Histone-lysine N-methyltransferase, H3 lysine-79 specific. (315 aa)
his-61Histone H2A. (127 aa)
his-60Histone H4. (103 aa)
his-62Probable histone H2B 4. (123 aa)
dot-1.4Histone-lysine N-methyltransferase, H3 lysine-79 specific. (383 aa)
oac-34Acyl_transf_3 domain-containing protein. (637 aa)
oac-35Acyl_transf_3 domain-containing protein. (663 aa)
oac-36Acyl_transf_3 domain-containing protein. (668 aa)
scvp-1Secreted nematode Clade V Protein gene family. (137 aa)
his-66Probable histone H2B 4. (123 aa)
his-65Histone H2A. (127 aa)
H05L14.2RING-type domain-containing protein. (1624 aa)
oac-37Acyl_transf_3 domain-containing protein. (659 aa)
his-38Histone H4. (103 aa)
K03B8.4Uncharacterized protein. (96 aa)
mys-2Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (533 aa)
his-18Histone H4. (103 aa)
his-19Histone H2A. (127 aa)
his-22Histone H2B 2. (123 aa)
his-28Histone H4. (103 aa)
his-21Histone H2A. (127 aa)
his-20Histone H2B 2. (123 aa)
rba-1Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. (412 aa)
lin-53Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repres [...] (417 aa)
phf-33PHD-type domain-containing protein. (650 aa)
oac-57Acyl_transf_3 domain-containing protein. (692 aa)
oac-58Acyl_transf_3 domain-containing protein. (695 aa)
set-12Histone-lysine N-methyltransferase. (389 aa)
set-13SET domain-containing protein. (402 aa)
hat-1Hat1_N domain-containing protein. (411 aa)
oac-40Acyl_transf_3 domain-containing protein. (642 aa)
oac-41Acyl_transf_3 domain-containing protein. (645 aa)
bus-1Acyl_transf_3 domain-containing protein. (646 aa)
met-2Histone-lysine N-methyltransferase met-2; Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3. This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9'. Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development. Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish betwee [...] (1304 aa)
mes-2Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...] (773 aa)
set-14SET domain-containing protein 14. (429 aa)
lsy-12Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1585 aa)
snfc-5SNF chromatin remodeling Complex component; Belongs to the SNF5 family. (381 aa)
set-15SET domain-containing protein. (611 aa)
amx-1Amine oxidase family member 1. (824 aa)
oac-42Acyl_transf_3 domain-containing protein. (558 aa)
lsd-1Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (737 aa)
oac-43Acyl_transf_3 domain-containing protein. (659 aa)
oac-44Acyl_transf_3 domain-containing protein. (650 aa)
oac-45Acyl_transf_3 domain-containing protein. (663 aa)
his-4Histone H2B 2. (123 aa)
his-3Histone H2A. (127 aa)
his-1Histone H4. (103 aa)
lin-59Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1312 aa)
chd-3Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. (1787 aa)
set-18MYND-type domain-containing protein. (507 aa)
T22B7.4SGF29 C-terminal domain-containing protein. (537 aa)
ruvb-2RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Has a role in gonadal development. Involved in the en [...] (448 aa)
prmt-9PRotein arginine MethylTransferase. (680 aa)
his-67Histone H4. (103 aa)
his-68Histone H2A. (127 aa)
oac-48Acyl_transf_3 domain-containing protein. (689 aa)
jhdm-1JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan. (1149 aa)
set-1Histone-lysine N-methyltransferase set-1; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis. Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites. Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily. (242 aa)
str-81Seven TM Receptor. (365 aa)
oac-49O-ACyltransferase homolog. (688 aa)
srr-2Serpentine Receptor, class R. (387 aa)
lin-40Uncharacterized protein. (1022 aa)
jmjc-1Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Mediates response to multiple stress stimuli, including heat shock and osmotic, oxidative, and ethanol stress; Belongs to the ROX family. NO66 subfamily. (748 aa)
mys-1Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family. (458 aa)
set-19SET domain-containing protein. (944 aa)
set-20SET (Trithorax/polycomb) domain containing. (552 aa)
hmg-20HMG box domain-containing protein. (386 aa)
oac-51Acyl_transf_3 domain-containing protein. (688 aa)
oac-52Acyl_transf_3 domain-containing protein. (686 aa)
dot-1.3Histone-lysine N-methyltransferase, H3 lysine-79 specific. (313 aa)
prmt-7Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). (647 aa)
mltn-11MLt-TeN (Mlt-10) related. (511 aa)
W09B6.4Uncharacterized protein. (256 aa)
Y102A11A.3Uncharacterized protein. (1556 aa)
Y104H12D.2Uncharacterized protein. (327 aa)
Y104H12D.4Uncharacterized protein. (107 aa)
ekl-4Uncharacterized protein. (488 aa)
set-33SET (Trithorax/polycomb) domain containing. (551 aa)
arid-1ARID domain-containing protein. (1648 aa)
elpc-1Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1250 aa)
Y113G7B.11Uncharacterized protein. (158 aa)
prmt-1Protein arginine N-methyltransferase 1; Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Catalyzes the formation of monomethylarginine and asymmetric dimethylarginine on histones H2A and H4, a specific tag for epigenetic transcriptional activation. Catalyzes asymmetric arginine dimethylation of mitochondrial proteins necessary for mitochondrial oxidative phosphorylation activity and thus aerobic respiration and ATP synthesis, and the mitochondrial stress response. Methylates arginine r [...] (348 aa)
swsn-1SANT domain-containing protein. (792 aa)
Y14H12B.2SPK domain-containing protein. (414 aa)
ash-2Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...] (575 aa)
Y17G9B.8SGF29 C-terminal domain-containing protein. (236 aa)
set-21SET domain-containing protein. (568 aa)
mes-4Histone-lysine N-methyltransferase mes-4; Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys- 36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to [...] (898 aa)
cec-7C.Elegans Chromodomain protein. (499 aa)
mrg-1MRG domain-containing protein. (337 aa)
dot-1.1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase, which in complex with zfp-1, methylates 'Lys-79' of histone H3 to activate transcription (Probable). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. Involved in controlling tissue-specific gene expression, particularly in the epidermis. (946 aa)
Y39H10A.6WD_REPEATS_REGION domain-containing protein. (672 aa)
spr-5Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] (770 aa)
set-23Probable histone-lysine N-methyltransferase set-23; Probable histone methyltransferase (By similarity). Required for embryonic development; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (244 aa)
Y43D4A.5Uncharacterized protein. (1545 aa)
set-25Histone-lysine N-methyltransferase set-25; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription- induced replication stress through methylation of H3K9. (714 aa)
Y44A6D.6Uncharacterized protein. (242 aa)
fbxa-215F-box domain-containing protein. (392 aa)
jmjd-2Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion. (922 aa)
ing-3Inhibitor of growth protein. (490 aa)
set-26Histone-lysine N-methyltransferase set-26; Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro. Involved in transcriptional regulation. Plays a role in the negative regulation of lifespan and in heat resistance. Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion. Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline. Together w [...] (1645 aa)
phf-15PHd Finger family. (741 aa)
oac-56Acyl_transf_3 domain-containing protein. (644 aa)
swsn-3HMG box domain-containing protein. (338 aa)
set-27SET domain-containing protein. (502 aa)
Y73B3A.1Uncharacterized protein. (613 aa)
Y73B3A.13annotation not available (418 aa)
fbxa-222F-box domain-containing protein. (377 aa)
rcor-1SANT domain-containing protein. (564 aa)
Y75B12B.1Uncharacterized protein. (202 aa)
Y75B8A.6Uncharacterized protein. (447 aa)
tag-164Uncharacterized protein. (278 aa)
Y9C9A.8F-box domain-containing protein. (415 aa)
ZC487.1ATP-grasp domain-containing protein. (450 aa)
dot-1.5Histone-lysine N-methyltransferase, H3 lysine-79 specific. (361 aa)
set-30MYND-type domain-containing protein. (560 aa)
ZK1127.3Uncharacterized protein. (206 aa)
ham-3SWIB domain-containing protein. (446 aa)
htas-1Histone H2A; Belongs to the histone H2A family. (145 aa)
his-26Histone H4. (103 aa)
his-16Histone H2A. (127 aa)
his-10Histone H4. (103 aa)
his-11Histone H2B 1. (122 aa)
his-12Histone H2A. (127 aa)
his-14Histone H4. (103 aa)
his-15Histone H2B 1. (122 aa)
rbr-2Lysine-specific demethylase rbr-2; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys- 27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Required for normal longevity of the soma in a germline-dependent manner. Implicated in the epigenetic inheritance of lifespan over several generations. Involved in larval development and vulva formation. (1477 aa)
swsn-6SWI/SNF nucleosome remodeling complex component; Belongs to the actin family. (436 aa)
elpc-3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] (547 aa)
dpy-30Dosage compensation protein dpy-30; Essential for dosage compensation. Required for the sex-specific association of the dosage compensation complex proteins dpy-27 and dpy-26 with the hermaphrodite X chromosomes. Plays a role in developmental rate and body fat regulation downstream of the TOR complex 2. Required for the robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. (123 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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