STRINGSTRING
marc-2 marc-2 cdc-48.1 cdc-48.1 kxd-1 kxd-1 marc-3 marc-3 cdc-48.2 cdc-48.2 C47E12.3 C47E12.3 marc-4 marc-4 marc-4-2 marc-4-2 eng-1 eng-1 F10C2.5 F10C2.5 mogs-1 mogs-1 ubxn-1 ubxn-1 ubq-1 ubq-1 cup-2 cup-2 uggt-2 uggt-2 rpt-2 rpt-2 F34H10.1 F34H10.1 aagr-3 aagr-3 uggt-1 uggt-1 F52C6.2 F52C6.2 F52C6.3 F52C6.3 aagr-4 aagr-4 marc-6 marc-6 png-1 png-1 sta-2 sta-2 marc-1 marc-1 ubl-1 ubl-1 cdc-48.3 cdc-48.3 K08C9.7 K08C9.7 R03E9.2 R03E9.2 mans-3 mans-3 crt-1 crt-1 marc-5 marc-5 mans-4 mans-4 ZC506.1 ZC506.1 ubq-2 ubq-2 cnx-1 cnx-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
marc-2RING-CH-type domain-containing protein. (206 aa)
cdc-48.1Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa)
kxd-1KxDL domain-containing protein. (140 aa)
marc-3RING-CH-type domain-containing protein. (431 aa)
cdc-48.2Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] (810 aa)
C47E12.3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (568 aa)
marc-4RING-CH-type domain-containing protein. (317 aa)
marc-4-2Uncharacterized protein. (73 aa)
eng-1Glyco_hydro_85 domain-containing protein. (433 aa)
F10C2.5alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (781 aa)
mogs-1Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically. (796 aa)
ubxn-1UBX domain-containing protein 1; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. (299 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
cup-2Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family. (245 aa)
uggt-2UDP-Glucose Glycoprotein glucosylTransferase. (1381 aa)
rpt-2Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1. (443 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
aagr-3DUF5110 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (924 aa)
uggt-1UDP-Glucose Glycoprotein glucosylTransferase. (1493 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
aagr-4Gal_mutarotas_2 domain-containing protein; Belongs to the glycosyl hydrolase 31 family. (903 aa)
marc-6RING-CH-type domain-containing protein. (1025 aa)
png-1Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta- aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native protein [...] (606 aa)
sta-2Signal transducer and activator of transcription b; Carries out a dual function: signal transduction and activation of transcription (By similarity). By regulating the up- regulation in the epidermis of antimicrobial peptides nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment. Belongs to the transcription factor STAT family. (567 aa)
marc-1RING-CH-type domain-containing protein. (206 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
cdc-48.3ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into she [...] (724 aa)
K08C9.7Uncharacterized protein. (154 aa)
R03E9.2Glyco_hydro_63 domain-containing protein. (619 aa)
mans-3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (584 aa)
crt-1Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegen [...] (395 aa)
marc-5RING-CH-type domain-containing protein. (470 aa)
mans-4alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (532 aa)
ZC506.1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (931 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
cnx-1Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death. (619 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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