STRINGSTRING
ubl-1 ubl-1 F10C2.4 F10C2.4 pole-2 pole-2 glo-4 glo-4 kin-33 kin-33 rfc-1 rfc-1 him-6 him-6 him-18 him-18 com-1 com-1 mus-81 mus-81 rfc-3 rfc-3 C39E9.12 C39E9.12 brc-1 brc-1 ubq-2 ubq-2 mre-11 mre-11 top-3 top-3 Y53F4B.3 Y53F4B.3 Y50D4C.3 Y50D4C.3 atm-1 atm-1 Y43D4A.6 Y43D4A.6 rad-51 rad-51 chk-1 chk-1 pcn-1 pcn-1 R03H10.7 R03H10.7 R03H10.6 R03H10.6 R02C2.6 R02C2.6 kin-34 kin-34 rmh-1 rmh-1 K08C9.7 K08C9.7 sdz-24 sdz-24 rfc-2 rfc-2 slx-1 slx-1 polh-1 polh-1 F52C6.3 F52C6.3 F52C6.2 F52C6.2 exo-1 exo-1 F44B9.8 F44B9.8 dna-2 dna-2 F42A6.5 F42A6.5 T26A5.8 T26A5.8 rmh-2 rmh-2 rad-50 rad-50 F34H10.1 F34H10.1 pole-1 pole-1 rfc-4 rfc-4 ubq-1 ubq-1 nars-1 nars-1 polk-1 polk-1 wrn-1 wrn-1 rfs-1 rfs-1 kxd-1 kxd-1 rpa-1 rpa-1 F12F6.7 F12F6.7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
F10C2.4DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). (1081 aa)
pole-2Probable DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (521 aa)
glo-4X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. (1386 aa)
kin-33Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa)
rfc-1Replication factor C subunit 1. (839 aa)
him-6Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. (988 aa)
him-18High Incidence of Males (Increased X chromosome loss). (718 aa)
com-1Completion Of Meiotic recombination (Budding yeast Com) related. (525 aa)
mus-81ERCC4 domain-containing protein. (445 aa)
rfc-3RFC (DNA replication factor) family. (354 aa)
C39E9.12SAP domain-containing protein. (409 aa)
brc-1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand [...] (612 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
mre-11Double-strand break repair protein mre-11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites. Belongs to the MRE11/RAD32 family. (728 aa)
top-3DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] (759 aa)
Y53F4B.3CBFD_NFYB_HMF domain-containing protein. (179 aa)
Y50D4C.3Tudor domain-containing protein. (605 aa)
atm-1Serine/threonine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability. Belongs to the PI3/PI4-kinase family. ATM subfamily. (2378 aa)
Y43D4A.6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (328 aa)
rad-51DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. (395 aa)
chk-1Serine/threonine-protein kinase chk-1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae. Essential for embryogene [...] (503 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
R03H10.7REPA_OB_2 domain-containing protein. (359 aa)
R03H10.6REPA_OB_2 domain-containing protein. (324 aa)
R02C2.6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (324 aa)
kin-34Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (311 aa)
rmh-1DUF1767 domain-containing protein. (926 aa)
K08C9.7Uncharacterized protein. (154 aa)
sdz-24OB domain-containing protein. (236 aa)
rfc-2AAA domain-containing protein. (334 aa)
slx-1Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...] (443 aa)
polh-1UmuC domain-containing protein. (584 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
exo-1EXOnuclease. (639 aa)
F44B9.8Probable replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (368 aa)
dna-2Yeast DNA helicase/endonuclease family. (1069 aa)
F42A6.5BRCT domain-containing protein. (102 aa)
T26A5.8CBFD_NFYB_HMF domain-containing protein. (137 aa)
rmh-2DUF1767 domain-containing protein. (615 aa)
rad-50DNA repair protein rad-50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity. (1312 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
pole-1DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2144 aa)
rfc-4Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity). (334 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
nars-1Asparagine--tRNA ligase, cytoplasmic; Involved in protein synthesis. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Belongs to the class-II aminoacyl-tRNA synthetase family. (545 aa)
polk-1DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). Belongs to the DNA polymerase type-Y family. (596 aa)
wrn-1Probable Werner syndrome ATP-dependent helicase homolog 1; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity). (1056 aa)
rfs-1RAD51-like protein 1; Has a role in the homologous recombination repair (HRR) of genomic DNA during meiosis. Required for rad-51 recruitment onto ssDNA gaps generated at stalled replication fork barriers. (245 aa)
kxd-1KxDL domain-containing protein. (140 aa)
rpa-1Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
F12F6.7Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. (451 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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