STRINGSTRING
rfc-2 rfc-2 ubl-1 ubl-1 F12F6.7 F12F6.7 ercc-1 ercc-1 F10C2.4 F10C2.4 pole-2 pole-2 glo-4 glo-4 parp-2 parp-2 rfc-1 rfc-1 xpf-1 xpf-1 rfc-3 rfc-3 C39E9.12 C39E9.12 kxd-1 kxd-1 K08C9.7 K08C9.7 ddb-1 ddb-1 gtf-2H1 gtf-2H1 R03H10.6 R03H10.6 R03H10.7 R03H10.7 gen-1 gen-1 gtf-2H2C gtf-2H2C T26A5.8 T26A5.8 pcn-1 pcn-1 xpd-1 xpd-1 Y53F4B.3 Y53F4B.3 gtf-2H5 gtf-2H5 xpb-1 xpb-1 parp-1 parp-1 Y73F8A.24 Y73F8A.24 Y75B7B.2 Y75B7B.2 tank-1 tank-1 ubq-2 ubq-2 gtf-2H3 gtf-2H3 rbx-1 rbx-1 rpa-1 rpa-1 polk-1 polk-1 xpa-1 xpa-1 ubq-1 ubq-1 rfc-4 rfc-4 pole-1 pole-1 F34H10.1 F34H10.1 F44B9.8 F44B9.8 cul-4 cul-4 F52C6.2 F52C6.2 F52C6.3 F52C6.3 xpg-1 xpg-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc-2AAA domain-containing protein. (334 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
F12F6.7Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. (451 aa)
ercc-1ERCC (DNA excision repair protein) homolog. (262 aa)
F10C2.4DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). (1081 aa)
pole-2Probable DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (521 aa)
glo-4X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. (1386 aa)
parp-2Poly [ADP-ribose] polymerase 2; Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death. (538 aa)
rfc-1Replication factor C subunit 1. (839 aa)
xpf-1ERCC4 domain-containing protein. (935 aa)
rfc-3RFC (DNA replication factor) family. (354 aa)
C39E9.12SAP domain-containing protein. (409 aa)
kxd-1KxDL domain-containing protein. (140 aa)
K08C9.7Uncharacterized protein. (154 aa)
ddb-1DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. (1134 aa)
gtf-2H1General Transcription Factor homolog. (532 aa)
R03H10.6REPA_OB_2 domain-containing protein. (324 aa)
R03H10.7REPA_OB_2 domain-containing protein. (359 aa)
gen-1GEN1 Holliday junction resolvase homolog. (434 aa)
gtf-2H2CGeneral transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (376 aa)
T26A5.8CBFD_NFYB_HMF domain-containing protein. (137 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
xpd-1Helicase ATP-binding domain-containing protein. (755 aa)
Y53F4B.3CBFD_NFYB_HMF domain-containing protein. (179 aa)
gtf-2H5General Transcription Factor homolog. (71 aa)
xpb-1XPB (Xeroderma Pigmentosum complementation group B) related. (789 aa)
parp-1Poly [ADP-ribose] polymerase 1; Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death. Involved in protection of the genome against mutations. (945 aa)
Y73F8A.24General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (485 aa)
Y75B7B.2ANK_REP_REGION domain-containing protein. (204 aa)
tank-1Poly [ADP-ribose] polymerase tankyrase; Poly[ADP-ribose] polymerases modify various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death. (2276 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
gtf-2H3General Transcription Factor homolog. (296 aa)
rbx-1RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa)
rpa-1Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
polk-1DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). Belongs to the DNA polymerase type-Y family. (596 aa)
xpa-1XPA_C domain-containing protein. (241 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
rfc-4Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity). (334 aa)
pole-1DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2144 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
F44B9.8Probable replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (368 aa)
cul-4Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. (840 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
xpg-1XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog. (820 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.