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| | kin-3 | Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2. (360 aa) |
| | air-2 | Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa) |
| | B0432.10 | Uncharacterized protein. (303 aa) |
| | unc-82 | Protein kinase domain-containing protein. (1793 aa) |
| | pro-2 | Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation. (715 aa) |
| | taf-3 | PHD-type domain-containing protein. (1007 aa) |
| | kxd-1 | KxDL domain-containing protein. (140 aa) |
| | brc-1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand [...] (612 aa) |
| | C36B7.1 | Protein kinase domain-containing protein. (450 aa) |
| | C36B7.2 | Protein kinase domain-containing protein. (446 aa) |
| | C39E9.12 | SAP domain-containing protein. (409 aa) |
| | rfc-3 | RFC (DNA replication factor) family. (354 aa) |
| | com-1 | Completion Of Meiotic recombination (Budding yeast Com) related. (525 aa) |
| | kin-33 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (337 aa) |
| | F08F1.9 | CYCLIN domain-containing protein; Belongs to the cyclin family. (130 aa) |
| | rpa-1 | Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa) |
| | wrn-1 | Probable Werner syndrome ATP-dependent helicase homolog 1; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity). (1056 aa) |
| | hpk-1 | Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood. Plays a role in the development/differentiation of gonadal distal tip cells. Required for normal lifespan in a pha-4 and mxl-2- dependent manner. Also contributes to survival following heat or oxidative stress. Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock. Also required [...] (846 aa) |
| | ubq-1 | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa) |
| | taf-5 | TAF (TBP-associated transcription factor) family. (648 aa) |
| | rfc-4 | Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity). (334 aa) |
| | hpr-17 | Homolog of S. Pombe Rad. (514 aa) |
| | F34H10.1 | Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa) |
| | mus-101 | Uncharacterized protein. (1182 aa) |
| | tlf-1 | TBP-Like Factor. (508 aa) |
| | F41E7.9 | Uncharacterized protein. (511 aa) |
| | F42A6.5 | BRCT domain-containing protein. (102 aa) |
| | taf-11.3 | TAFII28 domain-containing protein. (228 aa) |
| | dna-2 | Yeast DNA helicase/endonuclease family. (1069 aa) |
| | F44B9.8 | Probable replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (368 aa) |
| | exo-1 | EXOnuclease. (639 aa) |
| | taf-11.1 | TAFII28 domain-containing protein. (345 aa) |
| | mbk-2 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2; Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage. (817 aa) |
| | F52C12.6 | Protein kinase domain-containing protein. (245 aa) |
| | F52C6.2 | Ubiquitin-like domain-containing protein. (228 aa) |
| | F52C6.3 | Ubiquitin-like domain-containing protein. (197 aa) |
| | taf-7.1 | TAFII55_N domain-containing protein. (254 aa) |
| | spt-16 | FACT complex subunit spt-16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...] (1030 aa) |
| | aakb-1 | AMPKBI domain-containing protein. (269 aa) |
| | rfc-2 | AAA domain-containing protein. (334 aa) |
| | cya-2 | CYCLIN domain-containing protein; Belongs to the cyclin family. (123 aa) |
| | ubl-1 | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa) |
| | hus-1 | Checkpoint protein. (277 aa) |
| | taf-10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (179 aa) |
| | air-1 | Protein kinase domain-containing protein. (326 aa) |
| | sdz-24 | OB domain-containing protein. (236 aa) |
| | K08C9.7 | Uncharacterized protein. (154 aa) |
| | taf-11.2 | TAFII28 domain-containing protein. (281 aa) |
| | rmh-1 | DUF1767 domain-containing protein. (926 aa) |
| | aak-1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. (589 aa) |
| | kin-34 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (311 aa) |
| | R02C2.6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (324 aa) |
| | R03H10.6 | REPA_OB_2 domain-containing protein. (324 aa) |
| | R03H10.7 | REPA_OB_2 domain-containing protein. (359 aa) |
| | taf-4 | TAFH domain-containing protein. (523 aa) |
| | aak-2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...] (626 aa) |
| | kin-10 | Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2; Belongs to the casein kinase 2 subunit beta family. (235 aa) |
| | him-6 | Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily. (988 aa) |
| | rad-50 | DNA repair protein rad-50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity. (1312 aa) |
| | atl-1 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the c [...] (2531 aa) |
| | rmh-2 | DUF1767 domain-containing protein. (615 aa) |
| | T08D2.7 | Uncharacterized protein; Belongs to the protein kinase superfamily. (469 aa) |
| | taf-9 | TAF (TBP-associated transcription factor) family. (183 aa) |
| | tbp-1 | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (340 aa) |
| | cdka-1 | Cyclin-dependent kinase 5 activator 1; Activator of the kinase cdk-5 (By similarity). In several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles. In the ventral nerve cord, regulates the synaptic localization of the glutamate receptor, glr-1. In DA motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the polarized distribution of dense-core vesicles in DB motor neurons. May regulate these processes in association with cdk-5. May also play a role in GABAergic [...] (366 aa) |
| | cdk-5 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] (292 aa) |
| | taf-1 | Transcription initiation factor TFIID subunit 1; Component of general transcription factor TFIID which establishes the initiation site for mRNA transcription (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Required for early embryonic development. Essential for embryonic transcription of several genes. (1744 aa) |
| | W05G11.2 | Cyclin N-terminal domain-containing protein. (192 aa) |
| | taf-6.1 | TAF domain-containing protein. (470 aa) |
| | eri-3 | Enhanced RNAI (RNA interference). (578 aa) |
| | pinn-1 | Peptidyl-prolyl cis-trans isomerase. (161 aa) |
| | taf-7.2 | TAFII55_N domain-containing protein. (236 aa) |
| | aakg-1 | AMP-Activated protein Kinase Gamma subunit. (801 aa) |
| | taf-6.2 | TAF6_C domain-containing protein. (835 aa) |
| | taf-2 | Transcription initiation factor TFIID subunit 2; Component of general transcription factor TFIID which establishes the initiation site for mRNA transcription (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Belongs to the TAF2 family. (1092 aa) |
| | hpr-9 | Cell cycle checkpoint protein hpr-9; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. (521 aa) |
| | chk-1 | Serine/threonine-protein kinase chk-1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae. Essential for embryogene [...] (503 aa) |
| | mrt-2 | Cell cycle checkpoint protein RAD1 homolog mrt-2; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break- induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity). Belongs to the Rad1 family. (267 aa) |
| | Y43D4A.6 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (328 aa) |
| | aakb-2 | AMPKBI domain-containing protein. (274 aa) |
| | atm-1 | Serine/threonine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability. Belongs to the PI3/PI4-kinase family. ATM subfamily. (2378 aa) |
| | Y50D4C.3 | Tudor domain-containing protein. (605 aa) |
| | top-3 | DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] (759 aa) |
| | taf-12 | TFIID_20kDa domain-containing protein. (342 aa) |
| | slr-2 | Synthetic with Lin-35/Rb. (448 aa) |
| | par-4 | Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Controls the asymmetric cell division of the Q.p neuroblast lineage. Involved in mediating cell polarization via regulation of anillin family scaffold proteins. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. May phosphorylate par-1. Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein s [...] (617 aa) |
| | chk-2 | Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. (476 aa) |
| | mre-11 | Double-strand break repair protein mre-11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites. Belongs to the MRE11/RAD32 family. (728 aa) |
| | ubq-2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa) |
| | cya-1 | G2/mitotic-specific cyclin-A1; Involved in the control of the cell cycle after S phase. May bind to and activate cdk-1 and/or cdk-2 to promote cell cycle progression. Necessary for embryogenesis. Belongs to the cyclin family. Cyclin AB subfamily. (485 aa) |
| | ZK678.3 | annotation not available (163 aa) |
