STRINGSTRING
tlf-1 tlf-1 snpc-3.1 snpc-3.1 B0336.13 B0336.13 gtf-2F1 gtf-2F1 cids-1 cids-1 rpb-6 rpb-6 inst-1 inst-1 snpc-1.1 snpc-1.1 C06G3.8 C06G3.8 taf-13 taf-13 rpb-2 rpb-2 rpb-3 rpb-3 frpr-4 frpr-4 D1043.1 D1043.1 E01A2.2 E01A2.2 dic-1 dic-1 snpc-1.3 snpc-1.3 F10B5.8 F10B5.8 F19F10.12 F19F10.12 rpb-12 rpb-12 ncbp-2 ncbp-2 rpb-8 rpb-8 taf-5 taf-5 F32D1.3 F32D1.3 snpc-4 snpc-4 F32H5.4 F32H5.4 cids-2 cids-2 ama-1 ama-1 ncbp-1 ncbp-1 F38B6.6 F38B6.6 ccnk-1 ccnk-1 taf-11.3 taf-11.3 rpb-4 rpb-4 cit-1.2 cit-1.2 cit-1.1 cit-1.1 taf-11.1 taf-11.1 F52B5.2 F52B5.2 spt-4 spt-4 gtf-2E2 gtf-2E2 cdk-9 cdk-9 rpb-5 rpb-5 frpr-11 frpr-11 frpr-12 frpr-12 spt-5 spt-5 taf-11.2 taf-11.2 pqn-51 pqn-51 R02D3.4 R02D3.4 R05D3.3 R05D3.3 R05F9.11 R05F9.11 rpap-2 rpap-2 pcf-11 pcf-11 str-176 str-176 oat-1 oat-1 snpc-3.4 snpc-3.4 ssup-72 ssup-72 T13C2.7 T13C2.7 tbp-1 tbp-1 phf-30 phf-30 ztf-18 ztf-18 T26A8.4 T26A8.4 rpb-11 rpb-11 ttb-1 ttb-1 W04A4.5 W04A4.5 taf-6.1 taf-6.1 eri-3 eri-3 gtf-2A2 gtf-2A2 ell-1 ell-1 taf-6.2 taf-6.2 rpb-10 rpb-10 gtf-2F2 gtf-2F2 snpc-1.2 snpc-1.2 dyf-19 dyf-19 snpc-3.3 snpc-3.3 Y48G1BL.8 Y48G1BL.8 snpc-3.2 snpc-3.2 Y51A2D.18 Y51A2D.18 Y51A2D.7 Y51A2D.7 rpb-7 rpb-7 Y71H2B.2 Y71H2B.2 gtf-2E1 gtf-2E1 taf-8 taf-8 ZK1128.3 ZK1128.3 ceh-18 ceh-18 ZC376.6 ZC376.6 rpb-9 rpb-9 Y92H12A.4 Y92H12A.4 Y73B3A.8 Y73B3A.8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tlf-1TBP-Like Factor. (508 aa)
snpc-3.1SNAPc (Small Nuclear RNA Activating Complex) homolog. (425 aa)
B0336.13Transcription initiation factor IIA small chain homolog. (139 aa)
gtf-2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (481 aa)
cids-1CID domain-containing protein 1. (315 aa)
rpb-6Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of t [...] (137 aa)
inst-1INTegrator complex Subunit homolog. (1884 aa)
snpc-1.1SNAPc (Small Nuclear RNA Activating Complex) homolog. (473 aa)
C06G3.8Uncharacterized protein. (137 aa)
taf-13TAF (TBP-associated transcription factor) family. (121 aa)
rpb-2DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] (1194 aa)
rpb-3RPOLD domain-containing protein. (282 aa)
frpr-4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
D1043.1INTegrator complex Subunit homolog. (910 aa)
E01A2.2Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA- mediated gene silencing (RNAi) by miRNAs (By similarity). (712 aa)
dic-1VWFA domain-containing protein. (872 aa)
snpc-1.3SNAPc (Small Nuclear RNA Activating Complex) homolog. (426 aa)
F10B5.8INTegrator complex Subunit homolog. (608 aa)
F19F10.12Beta-Casp domain-containing protein. (646 aa)
rpb-12RNA Polymerase II (B) subunit. (62 aa)
ncbp-2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap stru [...] (158 aa)
rpb-8Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity); Belongs to the eukaryotic RPB8 RNA polymerase subunit family. (148 aa)
taf-5TAF (TBP-associated transcription factor) family. (648 aa)
F32D1.3TPR_REGION domain-containing protein. (774 aa)
snpc-4snRNA-activating protein complex subunit 4 homolog; Binds to the promoter regions of RNA polymerase II and III small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA genes, small nucleolar RNAs and transfer RNA genes. Required for expression of mature 21U-RNAs. (944 aa)
F32H5.4MFS domain-containing protein. (528 aa)
cids-2CID domain-containing protein. (664 aa)
ama-1DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
ncbp-1Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa)
F38B6.6Protein O-mannosyl-transferase TMTC1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. (690 aa)
ccnk-1CYCLIN domain-containing protein; Belongs to the cyclin family. (252 aa)
taf-11.3TAFII28 domain-containing protein. (228 aa)
rpb-4RPOL4c domain-containing protein. (144 aa)
cit-1.2Cyclin-T1.2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). (555 aa)
cit-1.1Cyclin-T1.1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). (468 aa)
taf-11.1TAFII28 domain-containing protein. (345 aa)
F52B5.2Protein kinase domain-containing protein. (301 aa)
spt-4Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex. (120 aa)
gtf-2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (289 aa)
cdk-9Probable cyclin-dependent kinase 9; Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5. (478 aa)
rpb-5DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (211 aa)
frpr-11G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
frpr-12G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (388 aa)
spt-5Transcription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex. Belongs to the SPT5 family. (1208 aa)
taf-11.2TAFII28 domain-containing protein. (281 aa)
pqn-51Prion-like-(Q/N-rich)-domain-bearing protein. (354 aa)
R02D3.4INTegrator complex Subunit homolog. (782 aa)
R05D3.3Putative zinc finger protein R05D3.3. (421 aa)
R05F9.11Uncharacterized protein. (525 aa)
rpap-2Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2; Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. Belongs to the RPAP2 family. (455 aa)
pcf-11Polyadenylation and cleavage factor homolog 11. (823 aa)
str-176MFS domain-containing protein. (540 aa)
oat-1Multispecific organic anion transporter. (526 aa)
snpc-3.4SNAPc (Small Nuclear RNA Activating Complex) homolog. (418 aa)
ssup-72RNA polymerase II subunit A C-terminal domain phosphatase ssup-72; Protein phosphatase that dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the large RNA polymerase II subunit ama-1. By regulating the phosphorylation status of ama-1 and thus ama-1 binding to specific polyadenylation sites, regulates alternative polyadenylation of pre- mRNAs, including unc-44 and dlk-1 mRNAs. This results in the tissue-specific expression of unc-44 isoforms. (197 aa)
T13C2.7Uncharacterized protein. (292 aa)
tbp-1TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (340 aa)
phf-30PHD-type domain-containing protein. (234 aa)
ztf-18C2H2-type domain-containing protein. (873 aa)
T26A8.4Uncharacterized protein. (574 aa)
rpb-11Probable DNA-directed RNA polymerase II subunit RPB11; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). (122 aa)
ttb-1Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. (306 aa)
W04A4.5INTegrator complex Subunit homolog. (1071 aa)
taf-6.1TAF domain-containing protein. (470 aa)
eri-3Enhanced RNAI (RNA interference). (578 aa)
gtf-2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. (113 aa)
ell-1Occludin_ELL domain-containing protein. (678 aa)
taf-6.2TAF6_C domain-containing protein. (835 aa)
rpb-10DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the cor [...] (67 aa)
gtf-2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (263 aa)
snpc-1.2SNAPc (Small Nuclear RNA Activating Complex) homolog. (445 aa)
dyf-19Uncharacterized protein. (534 aa)
snpc-3.3SNAPc (Small Nuclear RNA Activating Complex) homolog. (259 aa)
Y48G1BL.8Uncharacterized protein. (109 aa)
snpc-3.2SNAPc (Small Nuclear RNA Activating Complex) homolog. (425 aa)
Y51A2D.18MFS domain-containing protein. (550 aa)
Y51A2D.7INTegrator complex Subunit homolog. (1057 aa)
rpb-7S1 motif domain-containing protein. (197 aa)
Y71H2B.2RNA_GG_bind domain-containing protein. (341 aa)
gtf-2E1HTH TFE/IIEalpha-type domain-containing protein. (433 aa)
taf-8BTP domain-containing protein. (497 aa)
ZK1128.3Uncharacterized protein ZK1128.3. (360 aa)
ceh-18Homeobox protein ceh-18; Directs gonadal sheath cell differentiation and function. Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development. Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis. Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization. May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in [...] (542 aa)
ZC376.6INTegrator complex Subunit homolog. (1156 aa)
rpb-9TFIIS-type domain-containing protein; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (167 aa)
Y92H12A.4INTegrator complex Subunit homolog. (1052 aa)
Y73B3A.8annotation not available (60 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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