STRINGSTRING
tbb-4 tbb-4 memb-1 memb-1 arf-1.2 arf-1.2 unc-44 unc-44 ykt-6 ykt-6 C06B8.2 C06B8.2 cogc-2 cogc-2 C07A9.5 C07A9.5 copd-1 copd-1 C16D9.4 C16D9.4 C16D9.5 C16D9.5 dyci-1 dyci-1 gbf-1 gbf-1 dnc-4 dnc-4 dnc-2 dnc-2 C28H8.4 C28H8.4 sumv-1 sumv-1 tbb-2 tbb-2 arl-6 arl-6 dli-1 dli-1 rab-1 rab-1 cogc-5 cogc-5 mec-12 mec-12 tba-2 tba-2 mam-2 mam-2 arp-11 arp-11 C50C3.2 C50C3.2 ben-1 ben-1 snap-1 snap-1 cap-1 cap-1 E03H4.8 E03H4.8 F07F6.4 F07F6.4 gos-28 gos-28 erd-2 erd-2 F11A10.6 F11A10.6 tba-5 tba-5 tba-1 tba-1 F28G4.3 F28G4.3 tba-6 tba-6 golg-2 golg-2 copb-2 copb-2 tba-9 tba-9 tba-4 tba-4 arf-1.1 arf-1.1 cope-1 cope-1 F46F5.10 F46F5.10 F47G9.1 F47G9.1 syx-5 syx-5 arf-3 arf-3 copz-1 copz-1 nsf-1 nsf-1 tbb-1 tbb-1 K02B12.7 K02B12.7 cogc-6 cogc-6 uso-1 uso-1 spc-1 spc-1 unc-70 unc-70 memb-2 memb-2 cap-2 cap-2 M151.4 M151.4 cogc-8 cogc-8 allo-1 allo-1 sma-1 sma-1 tbb-6 tbb-6 T08D2.1 T08D2.1 T14G10.5 T14G10.5 dlc-1 dlc-1 tba-7 tba-7 sel-9 sel-9 dlc-3 dlc-3 dlc-4 dlc-4 flh-1 flh-1 flh-3 flh-3 Y19D2B.1 Y19D2B.1 copb-1 copb-1 Y27F2A.6 Y27F2A.6 Y39G10AR.11 Y39G10AR.11 Y41C4A.32 Y41C4A.32 Y45G12C.1 Y45G12C.1 Y51H7C.41 Y51H7C.41 cogc-4 cogc-4 cogc-1 cogc-1 dnc-6 dnc-6 Y59A8B.25 Y59A8B.25 Y59A8B.8 Y59A8B.8 nbet-1 nbet-1 Y60A3A.9 Y60A3A.9 dnc-5 dnc-5 copa-1 copa-1 cogc-3 cogc-3 Y73B6BL.37 Y73B6BL.37 dlc-5 dlc-5 ZK1053.1 ZK1053.1 mec-7 mec-7 dnc-1 dnc-1 arl-5 arl-5 tba-8 tba-8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbb-4Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
memb-1Golgi SNAP receptor complex member 2 homolog memb-1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (213 aa)
arf-1.2ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. (181 aa)
unc-44Uncharacterized protein. (6994 aa)
ykt-6YKT6 (Yeast v-SNARE) homolog; Belongs to the synaptobrevin family. (201 aa)
C06B8.2Uncharacterized protein. (433 aa)
cogc-2Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function. (681 aa)
C07A9.5Uncharacterized calcium-binding protein C07A9.5. (358 aa)
copd-1Probable coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (515 aa)
C16D9.4Uncharacterized protein. (384 aa)
C16D9.5Uncharacterized protein. (392 aa)
dyci-1WD_REPEATS_REGION domain-containing protein. (643 aa)
gbf-1SEC7 domain-containing protein. (1975 aa)
dnc-4DyNactin Complex component. (413 aa)
dnc-2Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. (331 aa)
C28H8.4ER lumen protein-retaining receptor erd-2.2; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity); Belongs to the ERD2 family. (213 aa)
sumv-1Protein sumv-1; Nuclear factor that influences the activity of genes involved in vulval development. (1024 aa)
tbb-2Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (450 aa)
arl-6ADP-ribosylation factor-like protein 6; Belongs to the small GTPase superfamily. Arf family. (190 aa)
dli-1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (443 aa)
rab-1RAB family. (205 aa)
cogc-5Conserved Oligomeric Golgi (COG) Component. (656 aa)
mec-12Detyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Component of the large-diameter neuronal microtubules which contains 15 protofilaments. Plays a role in mechanosensory transduction (touch sensitivity). (450 aa)
tba-2Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (448 aa)
mam-2MAM domain-containing protein. (774 aa)
arp-11Actin-Related Proteins; Belongs to the actin family. (384 aa)
C50C3.2Uncharacterized protein C50C3.2; Belongs to the spectrin family. (2236 aa)
ben-1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
snap-1SNAP (Soluble NSF Attachment Protein) homolog. (295 aa)
cap-1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
E03H4.8Coatomer_WDAD domain-containing protein. (368 aa)
F07F6.4Uncharacterized protein F07F6.4; GTPase-activating protein for the ADP ribosylation factor family. (529 aa)
gos-28Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation. (234 aa)
erd-2ER lumen protein-retaining receptor erd-2.1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity); Belongs to the ERD2 family. (213 aa)
F11A10.6Uncharacterized protein. (356 aa)
tba-5Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (447 aa)
tba-1Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
F28G4.3Uncharacterized protein. (358 aa)
tba-6Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (464 aa)
golg-2GOLGi associated coiled-coil protein homolog. (928 aa)
copb-2Probable coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity); Belongs to the WD repeat COPB2 family. (1000 aa)
tba-9Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
tba-4Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
arf-1.1ADP-ribosylation factor 1-like 1; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family. (179 aa)
cope-1Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (292 aa)
F46F5.10Uncharacterized protein. (369 aa)
F47G9.1GOLD domain-containing protein. (204 aa)
syx-5Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (413 aa)
arf-3ADP-ribosylation factor related (20.5 kD) (Arf-3); Belongs to the small GTPase superfamily. Arf family. (180 aa)
copz-1Probable coatomer subunit zeta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its associatio [...] (184 aa)
nsf-1Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity); Belongs to the AAA ATPase family. (824 aa)
tbb-1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
K02B12.7Arf-GAP domain-containing protein. (423 aa)
cogc-6Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (642 aa)
uso-1USO1 (Yeast transport protein) homolog. (941 aa)
spc-1SPeCtrin. (2432 aa)
unc-70Spectrin beta chain; Belongs to the spectrin family. (2326 aa)
memb-2Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (216 aa)
cap-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa)
M151.4Uncharacterized protein. (571 aa)
cogc-8Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. (743 aa)
allo-1Allophagy receptor allo-1; Autophagy receptor, which is required for allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in early embryos. After fertilization, recruited to ubiquitin-modified paternal organelles and is required for the formation of autophagosomes around the paternal organelles. Also plays a role in the regulation of autophagy in germ cells. (402 aa)
sma-1SMAll. (4166 aa)
tbb-6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (426 aa)
T08D2.1GOLD domain-containing protein. (167 aa)
T14G10.5Probable coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (885 aa)
dlc-1Dynein light chain 1, cytoplasmic; Acts as a non-catalytic accessory component of a dynein complex (By similarity). Part of a complex with bicd-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migrations in hypodermal precursor cells. Probably within a dynein motor complex, plays a role in the cell fate specification of the germline and oogenesis. In particular, it inhibits germ cell proliferation. Regulates the function and localization of the RNA-binding protein fbf- 2 in the germline. P [...] (89 aa)
tba-7Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
sel-9Suppressor/enhancer of lin-12 protein 9; May have a role in the negative regulation of lin-12 and glp- 1 transport to the cell surface. May also have a role in a quality control mechanism for endoplasmic reticulum-Golgi transport; the budding of coatomer-coated and other species of coated vesicles, could bind cargo molecules to collect them into budding vesicles. Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction. Belongs to the EMP24/GP25L family. (203 aa)
dlc-3Dynein light chain. (129 aa)
dlc-4Dynein light chain. (129 aa)
flh-1FLYWCH-type domain-containing protein. (507 aa)
flh-3FLYWCH-type domain-containing protein. (420 aa)
Y19D2B.1Uncharacterized protein. (85 aa)
copb-1Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (971 aa)
Y27F2A.6Uncharacterized protein. (487 aa)
Y39G10AR.11Uncharacterized protein. (788 aa)
Y41C4A.32WD_REPEATS_REGION domain-containing protein. (291 aa)
Y45G12C.1Uncharacterized protein. (378 aa)
Y51H7C.41Uncharacterized protein. (77 aa)
cogc-4Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function; Belongs to the COG4 family. (801 aa)
cogc-1Conserved Oligomeric Golgi (COG) Component. (787 aa)
dnc-6Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. (180 aa)
Y59A8B.25Uncharacterized protein. (145 aa)
Y59A8B.8Uncharacterized protein. (299 aa)
nbet-1t-SNARE coiled-coil homology domain-containing protein. (107 aa)
Y60A3A.9GOLD domain-containing protein. (211 aa)
dnc-5DyNactin Complex component. (184 aa)
copa-1Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1232 aa)
cogc-3Conserved Oligomeric Golgi (COG) Component. (794 aa)
Y73B6BL.37Lipase_GDSL domain-containing protein. (377 aa)
dlc-5Dynein Light Chain. (186 aa)
ZK1053.1Uncharacterized protein. (342 aa)
mec-7Tubulin beta-1 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity). (441 aa)
dnc-1CAP-Gly domain-containing protein. (1351 aa)
arl-5ADP-ribosylation factor-like protein 5; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells. (178 aa)
tba-8Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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