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mec-7 mec-7 dnc-1 dnc-1 dyci-1 dyci-1 tba-5 tba-5 dnc-4 dnc-4 dnc-2 dnc-2 sumv-1 sumv-1 dli-1 dli-1 bicd-1 bicd-1 mec-12 mec-12 C45B2.6 C45B2.6 tba-2 tba-2 arp-11 arp-11 ipla-4 ipla-4 cap-1 cap-1 tba-1 tba-1 tba-6 tba-6 atrn-1 atrn-1 tba-9 tba-9 tba-4 tba-4 F45F2.10 F45F2.10 ipla-2 ipla-2 rab-6.1 rab-6.1 ipla-5 ipla-5 rbg-1 rbg-1 cap-2 cap-2 lis-1 lis-1 ipla-7 ipla-7 coa-4 coa-4 rbg-2 rbg-2 rab-6.2 rab-6.2 dlc-1 dlc-1 tba-7 tba-7 ipla-3 ipla-3 dlc-3 dlc-3 tba-8 tba-8 dlc-4 dlc-4 Y19D2B.1 Y19D2B.1 Y45G5AM.9 Y45G5AM.9 dnc-6 dnc-6 dnc-5 dnc-5 dlc-5 dlc-5 rab-18 rab-18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mec-7Tubulin beta-1 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity). (441 aa)
dnc-1CAP-Gly domain-containing protein. (1351 aa)
dyci-1WD_REPEATS_REGION domain-containing protein. (643 aa)
tba-5Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (447 aa)
dnc-4DyNactin Complex component. (413 aa)
dnc-2Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family. (331 aa)
sumv-1Protein sumv-1; Nuclear factor that influences the activity of genes involved in vulval development. (1024 aa)
dli-1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (443 aa)
bicd-1Protein bicaudal D homolog; Part of a complex with dlc-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (Probable). Required for the formation of dendritic branches of PVD sensory neurons ; Belongs to the BicD family. (737 aa)
mec-12Detyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Component of the large-diameter neuronal microtubules which contains 15 protofilaments. Plays a role in mechanosensory transduction (touch sensitivity). (450 aa)
C45B2.6Uncharacterized protein. (762 aa)
tba-2Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (448 aa)
arp-11Actin-Related Proteins; Belongs to the actin family. (384 aa)
ipla-4Intracelllar PhosphoLipase A family. (557 aa)
cap-1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
tba-1Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
tba-6Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (464 aa)
atrn-1Putative protein tag-53. (1269 aa)
tba-9Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (456 aa)
tba-4Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
F45F2.10ANK_REP_REGION domain-containing protein. (980 aa)
ipla-2Intracelllar PhosphoLipase A family. (1071 aa)
rab-6.1Ras-related protein Rab-6.1; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
ipla-5Intracelllar PhosphoLipase A family. (497 aa)
rbg-1Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (915 aa)
cap-2F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa)
lis-1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in [...] (404 aa)
ipla-7PNPLA domain-containing protein. (471 aa)
coa-4Cytochrome Oxidase Assembly subunits. (293 aa)
rbg-2Rab3 GTPase-activating protein regulatory subunit; Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase- activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (1307 aa)
rab-6.2Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity). (205 aa)
dlc-1Dynein light chain 1, cytoplasmic; Acts as a non-catalytic accessory component of a dynein complex (By similarity). Part of a complex with bicd-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migrations in hypodermal precursor cells. Probably within a dynein motor complex, plays a role in the cell fate specification of the germline and oogenesis. In particular, it inhibits germ cell proliferation. Regulates the function and localization of the RNA-binding protein fbf- 2 in the germline. P [...] (89 aa)
tba-7Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ipla-3Intracelllar PhosphoLipase A family. (1047 aa)
dlc-3Dynein light chain. (129 aa)
tba-8Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
dlc-4Dynein light chain. (129 aa)
Y19D2B.1Uncharacterized protein. (85 aa)
Y45G5AM.9Uncharacterized protein. (499 aa)
dnc-6Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily. (180 aa)
dnc-5DyNactin Complex component. (184 aa)
dlc-5Dynein Light Chain. (186 aa)
rab-18Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells. (203 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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