STRINGSTRING
hrpl-1 hrpl-1 C46F11.4 C46F11.4 C47E8.4 C47E8.4 slrp-1 slrp-1 prp-8 prp-8 C50D2.5 C50D2.5 C50D2.8 C50D2.8 syf-1 syf-1 snr-4 snr-4 smu-1 smu-1 cyn-8 cyn-8 prp-38 prp-38 plrg-1 plrg-1 syf-2 syf-2 K07C5.6 K07C5.6 K07F5.14 K07F5.14 rnp-3 rnp-3 rnp-2 rnp-2 M01E11.2 M01E11.2 cey-3 cey-3 M01G5.1 M01G5.1 gut-2 gut-2 rbm-22 rbm-22 T12A2.6 T12A2.6 bcas-2 bcas-2 T13H5.4 T13H5.4 T16H12.9 T16H12.9 pqbp-1.1 pqbp-1.1 T23G11.4 T23G11.4 cyn-9 cyn-9 skp-1 skp-1 snr-3 snr-3 rsp-5 rsp-5 rpb-11 rpb-11 rsp-2 rsp-2 rsp-1 rsp-1 hrpf-1 hrpf-1 sftb-2 sftb-2 cacn-1 cacn-1 rbm-25 rbm-25 prp-3 prp-3 M03F8.3 M03F8.3 aly-3 aly-3 M88.4 M88.4 R07E5.1 R07E5.1 rnp-4 rnp-4 R08D7.1 R08D7.1 mag-1 mag-1 gkow-1 gkow-1 sup-46 sup-46 pnn-1 pnn-1 cyn-11 cyn-11 sel-13 sel-13 let-355 let-355 gad-1 gad-1 sftb-1 sftb-1 rbm-5 rbm-5 ztf-4 ztf-4 cwc-15 cwc-15 prp-19 prp-19 phf-5 phf-5 Y54G2A.12 Y54G2A.12 Y54G2A.75 Y54G2A.75 rsr-2 rsr-2 Y57G11A.5 Y57G11A.5 prp-6 prp-6 cus-2 cus-2 Y66D12A.8 Y66D12A.8 ddx-35 ddx-35 Y69A2AR.21 Y69A2AR.21 smr-1 smr-1 Y71F9AL.12 Y71F9AL.12 dnj-30 dnj-30 snr-7 snr-7 Y73B3A.8 Y73B3A.8 lsm-8 lsm-8 hrpf-2 hrpf-2 sqd-1 sqd-1 emb-4 emb-4 cyn-15 cyn-15 rpb-9 rpb-9 ZK1127.6 ZK1127.6 tcer-1 tcer-1 eftu-2 eftu-2 snr-5 snr-5 snu-23 snu-23 mog-4 mog-4 rnp-5 rnp-5 mog-1 mog-1 rnp-7 rnp-7 flp-3 flp-3 prp-21 prp-21 mtr-4 mtr-4 snr-2 snr-2 W08E3.2 W08E3.2 Y108F1.5 Y108F1.5 prp-31 prp-31 rsp-3 rsp-3 sfa-1 sfa-1 cyn-13 cyn-13 snr-1 snr-1 orc-3 orc-3 cdc-5L cdc-5L rsp-7 rsp-7 ptb-1 ptb-1 E01A2.2 E01A2.2 let-504 let-504 mog-5 mog-5 rsp-4 rsp-4 ddx-23 ddx-23 lin-28 lin-28 F08B4.7 F08B4.7 snrp-40.1 snrp-40.1 usp-39 usp-39 repo-1 repo-1 F14F9.5 F14F9.5 F19F10.9 F19F10.9 prpf-4 prpf-4 rpb-12 rpb-12 aly-2 aly-2 ncbp-2 ncbp-2 hrpk-1 hrpk-1 rpb-8 rpb-8 F28B4.3 F28B4.3 rsr-1 rsr-1 F32B6.3 F32B6.3 let-858 let-858 cey-1 cey-1 F33D11.10 F33D11.10 F33H1.3 F33H1.3 ama-1 ama-1 F37A4.2 F37A4.2 F37C12.1 F37C12.1 ncbp-1 ncbp-1 sig-7 sig-7 irg-7 irg-7 pqn-37 pqn-37 hrp-1 hrp-1 rpb-4 rpb-4 mfap-1 mfap-1 F43G9.12 F43G9.12 cey-2 cey-2 ubl-5 ubl-5 prp-17 prp-17 Y119D3B.12 Y119D3B.12 mog-3 mog-3 isy-1 isy-1 F53F4.14 F53F4.14 F53H1.1 F53H1.1 F54E4.4 F54E4.4 pes-4 pes-4 ddx-15 ddx-15 F56G4.4 F56G4.4 rbm-17 rbm-17 rde-12 rde-12 tag-65 tag-65 cyn-4 cyn-4 mog-2 mog-2 sacy-1 sacy-1 rpb-5 rpb-5 rnf-113 rnf-113 K01G5.8 K01G5.8 teg-4 teg-4 cyn-16 cyn-16 Y18H1A.2 Y18H1A.2 ccar-1 ccar-1 rbm-7 rbm-7 smgl-2 smgl-2 rpb-10 rpb-10 cey-4 cey-4 gtf-2F2 gtf-2F2 hrpu-1 hrpu-1 snrp-200 snrp-200 rnp-6 rnp-6 snr-6 snr-6 smu-2 smu-2 rpb-7 rpb-7 C02B8.12 C02B8.12 C02B10.4 C02B10.4 aly-1 aly-1 gtf-2F1 gtf-2F1 B0511.7 B0511.7 B0495.8 B0495.8 moa-2 moa-2 B0361.2 B0361.2 cyn-10 cyn-10 B0222.11 B0222.11 snrp-40.2 snrp-40.2 rsp-8 rsp-8 C18D11.3 C18D11.3 ccdc-55 ccdc-55 C16C10.4 C16C10.4 sap-49 sap-49 C07H6.4 C07H6.4 stip-1 stip-1 bud-31 bud-31 rpb-6 rpb-6 rpb-2 rpb-2 C29H12.6 C29H12.6 rbmx-2 rbmx-2 C32E8.5 C32E8.5 rsp-6 rsp-6 C34C6.3 C34C6.3 cyn-12 cyn-12 rpb-3 rpb-3 prp-4 prp-4 C39E9.11 C39E9.11 acin-1 acin-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hrpl-1Heterogeneous nuclear RibonucleoProtein (HnRNP) L homolog. (597 aa)
C46F11.4Uncharacterized protein. (811 aa)
C47E8.4Protein FAM50 homolog; Belongs to the FAM50 family. (326 aa)
slrp-1RRM domain-containing protein. (114 aa)
prp-8Pre-mRNA-splicing factor 8 homolog; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. (2329 aa)
C50D2.5Splicing factor 3B subunit 6-like protein; Necessary for the splicing of pre-mRNA. (138 aa)
C50D2.8Uncharacterized protein. (319 aa)
syf-1SYF pre-mRNA splicing factor homolog. (855 aa)
snr-4Probable small nuclear ribonucleoprotein Sm D2; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). (118 aa)
smu-1Smu-1 suppressor of mec-8 and unc-52 protein; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site. In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18. (510 aa)
cyn-8Peptidyl-prolyl cis-trans isomerase 8; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (466 aa)
prp-38Yeast PRP (Splicing factor) related. (320 aa)
plrg-1WD_REPEATS_REGION domain-containing protein. (494 aa)
syf-2Pre-mRNA-splicing factor syf-2; May be involved in pre-mRNA splicing. (234 aa)
K07C5.6Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Belongs to the SLU7 family. (647 aa)
K07F5.14Uncharacterized protein. (422 aa)
rnp-3RNP (RRM RNA binding domain) containing. (217 aa)
rnp-2RNP (RRM RNA binding domain) containing. (206 aa)
M01E11.2DUF1716 domain-containing protein. (544 aa)
cey-3CSD_1 domain-containing protein. (265 aa)
M01G5.1Uncharacterized protein. (891 aa)
gut-2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (97 aa)
rbm-22RNA Binding Motif protein homolog. (408 aa)
T12A2.6Uncharacterized protein. (689 aa)
bcas-2BCAS splicing factor homolog. (238 aa)
T13H5.4Matrin-type domain-containing protein. (500 aa)
T16H12.9Uncharacterized protein T16H12.9. (303 aa)
pqbp-1.1WW domain-containing protein. (280 aa)
T23G11.4Uncharacterized protein. (240 aa)
cyn-9Peptidyl-prolyl cis-trans isomerase 9; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Thought to function as a catalyst in the folding and modification of cuticle collagens. (309 aa)
skp-1Uncharacterized protein T27F2.1. (535 aa)
snr-3Probable small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures (By similarity). Belongs to the snRNP core protein family. (126 aa)
rsp-5Probable splicing factor, arginine/serine-rich 5; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites. (208 aa)
rpb-11Probable DNA-directed RNA polymerase II subunit RPB11; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). (122 aa)
rsp-2Probable splicing factor, arginine/serine-rich 2; Plays a functionally redundant role in spermatogenesis and growth rate control. Required for the development of somatic gonad structures and for progression from larval stage to adulthood. Belongs to the splicing factor SR family. (281 aa)
rsp-1Probable splicing factor, arginine/serine-rich 1; Plays a functionally redundant role in spermatogenesis and growth rate control. (312 aa)
hrpf-1HnRNP F homolog. (549 aa)
sftb-2PSP domain-containing protein. (602 aa)
cacn-1Cactin; Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis. (657 aa)
rbm-25PWI domain-containing protein. (707 aa)
prp-3Yeast PRP (Splicing factor) related. (621 aa)
M03F8.3Uncharacterized protein. (747 aa)
aly-3FoP_duplication domain-containing protein. (240 aa)
M88.4PID domain-containing protein. (365 aa)
R07E5.1G patch domain-containing protein 1 homolog. (812 aa)
rnp-4RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa)
R08D7.1BUD13 homolog; Belongs to the CWC26 family. (458 aa)
mag-1Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family. (152 aa)
gkow-1G-patch domain and KOW motifs-containing protein homolog 1; Belongs to the MOS2 family. (462 aa)
sup-46SUPpressor. (454 aa)
pnn-1Pinin_SDK_memA domain-containing protein. (359 aa)
cyn-11Peptidyl-prolyl cis-trans isomerase 11; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. PPIase H subfamily. (183 aa)
sel-13Suppressor/Enhancer of Lin-12. (234 aa)
let-355Uncharacterized protein. (856 aa)
gad-1Gastrulation defective protein 1; Required for initiation of gastrulation. (620 aa)
sftb-1SF3b1 domain-containing protein. (1322 aa)
rbm-5RNA Binding Motif protein homolog. (925 aa)
ztf-4RRM domain-containing protein. (367 aa)
cwc-15Spliceosome-associated protein CWC15 homolog; Component of a spliceosomal complex that is required for activating pre-mRNA splicing. (230 aa)
prp-19Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa)
phf-5PHd Finger family. (110 aa)
Y54G2A.12WD_REPEATS_REGION domain-containing protein. (274 aa)
Y54G2A.75Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
rsr-2Cwf21 domain-containing protein. (425 aa)
Y57G11A.5RRM domain-containing protein. (110 aa)
prp-6Yeast PRP (Splicing factor) related. (968 aa)
cus-2Uncharacterized protein. (442 aa)
Y66D12A.8Uncharacterized protein. (244 aa)
ddx-35Probable ATP-dependent RNA helicase DHX35 homolog. (732 aa)
Y69A2AR.21Uncharacterized protein. (169 aa)
smr-1SMN (Survival of Motor Neuron protein) Related. (239 aa)
Y71F9AL.12Uncharacterized protein. (289 aa)
dnj-30J domain-containing protein. (238 aa)
snr-7Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa)
Y73B3A.8annotation not available (60 aa)
lsm-8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
hrpf-2RRM domain-containing protein. (610 aa)
sqd-1Homologous to Drosophila SQD (Squid) protein. (308 aa)
emb-4Uncharacterized protein. (1467 aa)
cyn-15PPIase cyclophilin-type domain-containing protein. (629 aa)
rpb-9TFIIS-type domain-containing protein; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (167 aa)
ZK1127.6Uncharacterized protein. (424 aa)
tcer-1WW domain-containing protein. (914 aa)
eftu-2Tr-type G domain-containing protein. (974 aa)
snr-5Probable small nuclear ribonucleoprotein F; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. (85 aa)
snu-23Putative zinc finger matrin-type protein snu-23. (217 aa)
mog-4Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4; ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis. (1008 aa)
rnp-5RRM domain-containing protein. (289 aa)
mog-1Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. (1131 aa)
rnp-7RRM domain-containing protein. (332 aa)
flp-3FMRFamide-like neuropeptides 3; FMRFamides and FMRFamide-like peptides are neuropeptides. SAEPFGTMRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (184 aa)
prp-21Yeast PRP (Splicing factor) related. (655 aa)
mtr-4mRNA transport homolog 4. (1026 aa)
snr-2Probable small nuclear ribonucleoprotein-associated protein B; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure (By similarity); Belongs to the snRNP SmB/SmN family. (160 aa)
W08E3.2Btz domain-containing protein. (584 aa)
Y108F1.5HA2 domain-containing protein. (330 aa)
prp-31Nop domain-containing protein. (504 aa)
rsp-3Probable splicing factor, arginine/serine-rich 3; Plays an essential role in embryogenesis. (258 aa)
sfa-1CCHC-type domain-containing protein. (699 aa)
cyn-13Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. (331 aa)
snr-1Small nuclear ribonucleoprotein Sm D3; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity); Belongs to the snRNP core protein family. (136 aa)
orc-3ORC (Origin Recognition Complex) subunit. (612 aa)
cdc-5LCell Division Cycle related. (755 aa)
rsp-7Probable splicing factor, arginine/serine-rich 7. (452 aa)
ptb-1Putative RNA-binding protein PTB-1a. (615 aa)
E01A2.2Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA- mediated gene silencing (RNAi) by miRNAs (By similarity). (712 aa)
let-504Nkap_C domain-containing protein. (504 aa)
mog-5Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5; Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. (1200 aa)
rsp-4Probable splicing factor, arginine/serine-rich 4; May play a functionally redundant role in embryogenesis. Belongs to the splicing factor SR family. (196 aa)
ddx-23DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (730 aa)
lin-28Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. (227 aa)
F08B4.7U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (142 aa)
snrp-40.1WD_REPEATS_REGION domain-containing protein. (331 aa)
usp-39Ubiquitin Specific Protease. (602 aa)
repo-1Matrin-type domain-containing protein. (222 aa)
F14F9.5Uncharacterized protein F14F9.5. (314 aa)
F19F10.9Uncharacterized protein. (829 aa)
prpf-4Protein kinase domain-containing protein. (775 aa)
rpb-12RNA Polymerase II (B) subunit. (62 aa)
aly-2FoP_duplication domain-containing protein. (227 aa)
ncbp-2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap stru [...] (158 aa)
hrpk-1Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response. (397 aa)
rpb-8Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity); Belongs to the eukaryotic RPB8 RNA polymerase subunit family. (148 aa)
F28B4.3Uncharacterized protein. (2229 aa)
rsr-1PWI domain-containing protein. (601 aa)
F32B6.3SFM domain-containing protein. (352 aa)
let-858Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family. (897 aa)
cey-1CSD_1 domain-containing protein. (208 aa)
F33D11.10Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa)
F33H1.3Uncharacterized protein F33H1.3. (359 aa)
ama-1DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
F37A4.2Uncharacterized protein F37A4.2. (189 aa)
F37C12.1Uncharacterized protein. (323 aa)
ncbp-1Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa)
sig-7Peptidyl-prolyl cis-trans isomerase sig-7; Probable PPIase that accelerates the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in RNA polymerase II (RNA pol II)-mediated transcription elongation, and in primary transcript splicing, including co-transcriptional trans- splicing, in association with the catalytic subunit of the RNA pol II complex ama-1. Also plays a role in the regulation of elongation-dependent phosphorylation of ama-1 to control transcription. Involved in the transc [...] (427 aa)
irg-7Protein irg-7; Plays a role in innate immunity, probably via the atf-7 pathway, to confer resistance to pathogenic bacteria. May also play a role in the regulation of longevity. (2217 aa)
pqn-37Prion-like-(Q/N-rich)-domain-bearing protein. (556 aa)
hrp-1Heterogeneous nuclear ribonucleoprotein A1; This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan. (347 aa)
rpb-4RPOL4c domain-containing protein. (144 aa)
mfap-1Microfibrillar-associated protein 1; Involved in pre-mRNA splicing. (466 aa)
F43G9.12GCFC domain-containing protein. (809 aa)
cey-2CSD_1 domain-containing protein. (267 aa)
ubl-5Ubiquitin-like protein 5. (73 aa)
prp-17WD_REPEATS_REGION domain-containing protein. (567 aa)
Y119D3B.12Uncharacterized protein. (339 aa)
mog-3Sex determining protein MOG-3. (451 aa)
isy-1Protein isy-1; Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10. Does not affect the splicing of zip-10 ; Belongs to the ISY1 family. (267 aa)
F53F4.14Sde2_N_Ubi domain-containing protein. (500 aa)
F53H1.1Uncharacterized protein. (970 aa)
F54E4.4Uncharacterized protein. (487 aa)
pes-4Patterned Expression Site. (432 aa)
ddx-15Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. (739 aa)
F56G4.4U1-type domain-containing protein. (470 aa)
rbm-17RNA Binding Motif protein homolog. (371 aa)
rde-12DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1. (959 aa)
tag-65SR-related CTD associated factor 6. (675 aa)
cyn-4Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development. (523 aa)
mog-2Probable U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing. (253 aa)
sacy-1Suppressor of ACY-4 sterility; Belongs to the DEAD box helicase family. (630 aa)
rpb-5DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (211 aa)
rnf-113Probable E3 ubiquitin-protein ligase rnf113; May function as E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. May play a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit proteins involved in repair to sites of DNA damage by alkylating agents. (384 aa)
K01G5.8Uncharacterized protein. (107 aa)
teg-4CPSF_A domain-containing protein. (1220 aa)
cyn-16PPIase cyclophilin-type domain-containing protein. (483 aa)
Y18H1A.2Cir_N domain-containing protein. (286 aa)
ccar-1SAP domain-containing protein. (1215 aa)
rbm-7RRM domain-containing protein. (243 aa)
smgl-2Uncharacterized protein. (1089 aa)
rpb-10DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the cor [...] (67 aa)
cey-4CSP domain-containing protein. (294 aa)
gtf-2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (263 aa)
hrpu-1B30.2/SPRY domain-containing protein. (1667 aa)
snrp-200Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily. (2145 aa)
rnp-6RNP (RRM RNA binding domain) containing. (749 aa)
snr-6Probable small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (90 aa)
smu-2Smu-2 suppressor of mec-8 and unc-52 protein; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-2 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17. In contrast, smu-2 mutants do not suppress the effects of an unc-52 mutation that affects the 5' splice site of exon 16. Required for normal accumulation of smu-1. Belongs to the RED family. (547 aa)
rpb-7S1 motif domain-containing protein. (197 aa)
C02B8.12Uncharacterized protein. (362 aa)
C02B10.4RRM domain-containing protein. (211 aa)
aly-1FoP_duplication domain-containing protein. (223 aa)
gtf-2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (481 aa)
B0511.7FHA domain-containing protein. (302 aa)
B0495.8Uncharacterized protein B0495.8; Belongs to the Luc7 family. (313 aa)
moa-2Protein moa-2. (87 aa)
B0361.2CWF19-like protein 2 homolog; Belongs to the CWF19 family. (460 aa)
cyn-10Peptidyl-prolyl cis-trans isomerase 10; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (161 aa)
B0222.11Uncharacterized protein. (356 aa)
snrp-40.2WD_REPEATS_REGION domain-containing protein. (331 aa)
rsp-8RRM domain-containing protein. (309 aa)
C18D11.3Uncharacterized protein. (175 aa)
ccdc-55Nuclear speckle splicing regulatory protein 1 homolog; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the NSRP1 family. (392 aa)
C16C10.4Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. (166 aa)
sap-49Splicing factor 3B subunit 4; Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity). (388 aa)
C07H6.4Uncharacterized protein. (933 aa)
stip-1Septin and tuftelin-interacting protein 1 homolog; May be involved in pre-mRNA splicing (By similarity). Required for embryonic development and survival. (830 aa)
bud-31Protein BUD31 homolog; Involved in pre-mRNA splicing process. (147 aa)
rpb-6Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of t [...] (137 aa)
rpb-2DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] (1194 aa)
C29H12.6Uncharacterized protein. (316 aa)
rbmx-2RRM domain-containing protein. (302 aa)
C32E8.5FHA domain-containing protein. (299 aa)
rsp-6Probable splicing factor, arginine/serine-rich 6; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood; Belongs to the splicing factor SR family. (179 aa)
C34C6.3Uncharacterized protein. (529 aa)
cyn-12Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (169 aa)
rpb-3RPOLD domain-containing protein. (282 aa)
prp-4WD_REPEATS_REGION domain-containing protein. (496 aa)
C39E9.11Proline Rich mitotic Checkpoint Control factor homolog. (405 aa)
acin-1ACINus (Mammalian Apoptotic Chromatin condensation Inducer in the Nucleus) homolog. (580 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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