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| | rpb-3 | RPOLD domain-containing protein. (282 aa) |
| | cyn-12 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (169 aa) |
| | C34C6.3 | Uncharacterized protein. (529 aa) |
| | rsp-6 | Probable splicing factor, arginine/serine-rich 6; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood; Belongs to the splicing factor SR family. (179 aa) |
| | C32E8.5 | FHA domain-containing protein. (299 aa) |
| | rbmx-2 | RRM domain-containing protein. (302 aa) |
| | C29H12.6 | Uncharacterized protein. (316 aa) |
| | npp-15 | Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family. (1129 aa) |
| | rpb-2 | DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] (1194 aa) |
| | hel-1 | Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly. (425 aa) |
| | sup-46 | SUPpressor. (454 aa) |
| | snrp-40.2 | WD_REPEATS_REGION domain-containing protein. (331 aa) |
| | rsp-8 | RRM domain-containing protein. (309 aa) |
| | C18D11.3 | Uncharacterized protein. (175 aa) |
| | pabp-2 | RRM domain-containing protein. (205 aa) |
| | ccdc-55 | Nuclear speckle splicing regulatory protein 1 homolog; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the NSRP1 family. (392 aa) |
| | C16C10.4 | Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family. (166 aa) |
| | thoc-2 | THO Complex (Transcription factor/nuclear export) subunit. (1437 aa) |
| | nxf-2 | Nuclear RNA export factor 2; May be involved in the export of cellular mRNA to the cytoplasm; Belongs to the NXF family. (405 aa) |
| | nxf-1 | Nuclear RNA export factor 1; Involved in RNA export from the nucleus to the cytoplasm; Belongs to the NXF family. (609 aa) |
| | npp-23 | Nuclear Pore complex Protein. (371 aa) |
| | sap-49 | Splicing factor 3B subunit 4; Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity). (388 aa) |
| | C07H6.4 | Uncharacterized protein. (933 aa) |
| | stip-1 | Septin and tuftelin-interacting protein 1 homolog; May be involved in pre-mRNA splicing (By similarity). Required for embryonic development and survival. (830 aa) |
| | bud-31 | Protein BUD31 homolog; Involved in pre-mRNA splicing process. (147 aa) |
| | rpb-6 | Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of t [...] (137 aa) |
| | mog-4 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4; ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis. (1008 aa) |
| | npp-14 | Nuclear pore complex protein 14; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity). Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4. (1390 aa) |
| | npp-4 | Nuclear Pore complex Protein. (538 aa) |
| | rpb-7 | S1 motif domain-containing protein. (197 aa) |
| | Y53G8AR.6 | SAP domain-containing protein. (253 aa) |
| | Y51H4A.23 | Uncharacterized protein. (257 aa) |
| | Y51H4A.22 | Uncharacterized protein. (283 aa) |
| | smu-2 | Smu-2 suppressor of mec-8 and unc-52 protein; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-2 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17. In contrast, smu-2 mutants do not suppress the effects of an unc-52 mutation that affects the 5' splice site of exon 16. Required for normal accumulation of smu-1. Belongs to the RED family. (547 aa) |
| | snr-6 | Probable small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (90 aa) |
| | Y47G6A.26 | Uncharacterized protein. (196 aa) |
| | rnp-6 | RNP (RRM RNA binding domain) containing. (749 aa) |
| | snrp-200 | Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily. (2145 aa) |
| | npp-18 | Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus. (363 aa) |
| | hrpu-1 | B30.2/SPRY domain-containing protein. (1667 aa) |
| | npp-8 | Nuclear Pore complex Protein. (1340 aa) |
| | gtf-2F2 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (263 aa) |
| | cey-4 | CSP domain-containing protein. (294 aa) |
| | rpb-10 | DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the cor [...] (67 aa) |
| | npp-13 | Nuclear pore protein. (787 aa) |
| | smgl-2 | Uncharacterized protein. (1089 aa) |
| | Y37E11AL.9 | Uncharacterized protein. (133 aa) |
| | rbm-7 | RRM domain-containing protein. (243 aa) |
| | ccar-1 | SAP domain-containing protein. (1215 aa) |
| | thoc-5 | THO Complex (Transcription factor/nuclear export) subunit. (599 aa) |
| | pap-1 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (655 aa) |
| | Y18H1A.2 | Cir_N domain-containing protein. (286 aa) |
| | C02B8.12 | Uncharacterized protein. (362 aa) |
| | C02B10.4 | RRM domain-containing protein. (211 aa) |
| | aly-1 | FoP_duplication domain-containing protein. (223 aa) |
| | gtf-2F1 | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (481 aa) |
| | thoc-7 | THO Complex (Transcription factor/nuclear export) subunit. (210 aa) |
| | B0511.7 | FHA domain-containing protein. (302 aa) |
| | B0511.2 | annotation not available (468 aa) |
| | B0495.8 | Uncharacterized protein B0495.8; Belongs to the Luc7 family. (313 aa) |
| | moa-2 | Protein moa-2. (87 aa) |
| | B0361.2 | CWF19-like protein 2 homolog; Belongs to the CWF19 family. (460 aa) |
| | ife-3 | Eukaryotic translation initiation factor 4E-3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...] (251 aa) |
| | cyn-10 | Peptidyl-prolyl cis-trans isomerase 10; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (161 aa) |
| | npp-22 | Nucleoporin ndc-1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope; Belongs to the NDC1 family. (588 aa) |
| | B0222.11 | Uncharacterized protein. (356 aa) |
| | sart-3 | SART-3/p110 homolog. (836 aa) |
| | snu-23 | Putative zinc finger matrin-type protein snu-23. (217 aa) |
| | snr-5 | Probable small nuclear ribonucleoprotein F; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. (85 aa) |
| | npp-10 | Nuclear pore complex protein Nup98-Nup96; Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase. Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes. Binds nos-2 mRNA, probably indirectly, and promotes its accu [...] (1678 aa) |
| | eftu-2 | Tr-type G domain-containing protein. (974 aa) |
| | npp-24 | Protein npp-24. (655 aa) |
| | ZK131.11 | Uncharacterized protein. (449 aa) |
| | ZK1225.5 | Uncharacterized protein. (511 aa) |
| | ZK1225.4 | Uncharacterized protein. (519 aa) |
| | ZK1128.3 | Uncharacterized protein ZK1128.3. (360 aa) |
| | tcer-1 | WW domain-containing protein. (914 aa) |
| | ZK1127.6 | Uncharacterized protein. (424 aa) |
| | ZK1053.4 | Uncharacterized protein. (701 aa) |
| | rpb-9 | TFIIS-type domain-containing protein; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (167 aa) |
| | uaf-1 | Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity). (496 aa) |
| | cyn-15 | PPIase cyclophilin-type domain-containing protein. (629 aa) |
| | Y82E9BR.2 | Uncharacterized protein. (530 aa) |
| | emb-4 | Uncharacterized protein. (1467 aa) |
| | npp-20 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family. (313 aa) |
| | cpsf-1 | Probable cleavage and polyadenylation specificity factor subunit 1; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). (1454 aa) |
| | sqd-1 | Homologous to Drosophila SQD (Squid) protein. (308 aa) |
| | hrpf-2 | RRM domain-containing protein. (610 aa) |
| | lsm-8 | U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa) |
| | Y73B3A.8 | annotation not available (60 aa) |
| | snr-7 | Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa) |
| | dnj-30 | J domain-containing protein. (238 aa) |
| | nxt-1 | NTF2-related export protein; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). (137 aa) |
| | Y71F9AL.12 | Uncharacterized protein. (289 aa) |
| | smr-1 | SMN (Survival of Motor Neuron protein) Related. (239 aa) |
| | Y69A2AR.21 | Uncharacterized protein. (169 aa) |
| | cpsf-3 | Cleavage and Polyadenylation Specificity Factor. (707 aa) |
| | ddx-35 | Probable ATP-dependent RNA helicase DHX35 homolog. (732 aa) |
| | Y66D12A.8 | Uncharacterized protein. (244 aa) |
| | cus-2 | Uncharacterized protein. (442 aa) |
| | prp-6 | Yeast PRP (Splicing factor) related. (968 aa) |
| | Y57G11A.5 | RRM domain-containing protein. (110 aa) |
| | rsr-2 | Cwf21 domain-containing protein. (425 aa) |
| | npp-16 | Nuclear Pore complex Protein. (497 aa) |
| | Y54G2A.75 | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa) |
| | Y54G2A.12 | WD_REPEATS_REGION domain-containing protein. (274 aa) |
| | phf-5 | PHd Finger family. (110 aa) |
| | cyn-16 | PPIase cyclophilin-type domain-containing protein. (483 aa) |
| | pes-4 | Patterned Expression Site. (432 aa) |
| | Y119D3B.12 | Uncharacterized protein. (339 aa) |
| | orc-3 | ORC (Origin Recognition Complex) subunit. (612 aa) |
| | snr-1 | Small nuclear ribonucleoprotein Sm D3; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity); Belongs to the snRNP core protein family. (136 aa) |
| | uaf-2 | U2AF splicing factor. (285 aa) |
| | cyn-13 | Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. (331 aa) |
| | sfa-1 | CCHC-type domain-containing protein. (699 aa) |
| | rsp-3 | Probable splicing factor, arginine/serine-rich 3; Plays an essential role in embryogenesis. (258 aa) |
| | prp-31 | Nop domain-containing protein. (504 aa) |
| | Y108F1.5 | HA2 domain-containing protein. (330 aa) |
| | W08E3.2 | Btz domain-containing protein. (584 aa) |
| | snr-2 | Probable small nuclear ribonucleoprotein-associated protein B; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure (By similarity); Belongs to the snRNP SmB/SmN family. (160 aa) |
| | mtr-4 | mRNA transport homolog 4. (1026 aa) |
| | prp-21 | Yeast PRP (Splicing factor) related. (655 aa) |
| | flp-3 | FMRFamide-like neuropeptides 3; FMRFamides and FMRFamide-like peptides are neuropeptides. SAEPFGTMRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (184 aa) |
| | rbm-25 | PWI domain-containing protein. (707 aa) |
| | cacn-1 | Cactin; Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis. (657 aa) |
| | sftb-2 | PSP domain-containing protein. (602 aa) |
| | hrpf-1 | HnRNP F homolog. (549 aa) |
| | rsp-1 | Probable splicing factor, arginine/serine-rich 1; Plays a functionally redundant role in spermatogenesis and growth rate control. (312 aa) |
| | rsp-2 | Probable splicing factor, arginine/serine-rich 2; Plays a functionally redundant role in spermatogenesis and growth rate control. Required for the development of somatic gonad structures and for progression from larval stage to adulthood. Belongs to the splicing factor SR family. (281 aa) |
| | W02B12.13 | Uncharacterized protein. (262 aa) |
| | rpb-11 | Probable DNA-directed RNA polymerase II subunit RPB11; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). (122 aa) |
| | rsp-5 | Probable splicing factor, arginine/serine-rich 5; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites. (208 aa) |
| | snr-3 | Probable small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures (By similarity). Belongs to the snRNP core protein family. (126 aa) |
| | skp-1 | Uncharacterized protein T27F2.1. (535 aa) |
| | cyn-9 | Peptidyl-prolyl cis-trans isomerase 9; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Thought to function as a catalyst in the folding and modification of cuticle collagens. (309 aa) |
| | npp-12 | Nuclear Pore complex Protein. (1847 aa) |
| | T23G11.4 | Uncharacterized protein. (240 aa) |
| | pqbp-1.1 | WW domain-containing protein. (280 aa) |
| | npp-7 | Nuclear Pore complex Protein. (1217 aa) |
| | T16H12.9 | Uncharacterized protein T16H12.9. (303 aa) |
| | T15H9.6 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa) |
| | T13H5.4 | Matrin-type domain-containing protein. (500 aa) |
| | drr-2 | RRM domain-containing protein. (207 aa) |
| | bcas-2 | BCAS splicing factor homolog. (238 aa) |
| | T12A2.6 | Uncharacterized protein. (689 aa) |
| | rbm-22 | RNA Binding Motif protein homolog. (408 aa) |
| | gut-2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (97 aa) |
| | prp-19 | Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family. (492 aa) |
| | cwc-15 | Spliceosome-associated protein CWC15 homolog; Component of a spliceosomal complex that is required for activating pre-mRNA splicing. (230 aa) |
| | ztf-4 | RRM domain-containing protein. (367 aa) |
| | T08B6.9 | Uncharacterized protein. (531 aa) |
| | sgnh-1 | RRM domain-containing protein. (177 aa) |
| | T08B6.1 | Uncharacterized protein. (96 aa) |
| | rbm-5 | RNA Binding Motif protein homolog. (925 aa) |
| | sftb-1 | SF3b1 domain-containing protein. (1322 aa) |
| | gad-1 | Gastrulation defective protein 1; Required for initiation of gastrulation. (620 aa) |
| | let-355 | Uncharacterized protein. (856 aa) |
| | T04D3.1 | Uncharacterized protein. (454 aa) |
| | sel-13 | Suppressor/Enhancer of Lin-12. (234 aa) |
| | thoc-1 | THO Complex (Transcription factor/nuclear export) subunit. (665 aa) |
| | npp-2 | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (598 aa) |
| | cyn-11 | Peptidyl-prolyl cis-trans isomerase 11; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. PPIase H subfamily. (183 aa) |
| | pnn-1 | Pinin_SDK_memA domain-containing protein. (359 aa) |
| | pcf-11 | Polyadenylation and cleavage factor homolog 11. (823 aa) |
| | ran-5 | RanBD1 domain-containing protein. (340 aa) |
| | gkow-1 | G-patch domain and KOW motifs-containing protein homolog 1; Belongs to the MOS2 family. (462 aa) |
| | mag-1 | Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family. (152 aa) |
| | rbm-3.2 | RRM domain-containing protein. (85 aa) |
| | rbm-3.1 | RRM domain-containing protein. (83 aa) |
| | R08D7.1 | BUD13 homolog; Belongs to the CWC26 family. (458 aa) |
| | rnp-4 | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa) |
| | R07E5.1 | G patch domain-containing protein 1 homolog. (812 aa) |
| | npp-19 | Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). Required for the proper organization of chromosomes on the mitotic spindle during anaphase. (381 aa) |
| | cdl-1 | Histone RNA hairpin-binding protein; Involved in histone pre-mRNA 3' processing. Required for chromosome condensation, progression of cell death and morphogenesis. (382 aa) |
| | R06C1.4 | RRM domain-containing protein. (84 aa) |
| | pfs-2 | pre-mRNA 3' end processing protein pfs-2; Essential for both cleavage and polyadenylation of pre-mRNA 3' ends (By similarity). Involved in neuron development, probably by regulating pre-mRNA 3'-end processing. (820 aa) |
| | ife-2 | Eukaryotic translation initiation factor 4E-2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...] (228 aa) |
| | M88.4 | PID domain-containing protein. (365 aa) |
| | aly-3 | FoP_duplication domain-containing protein. (240 aa) |
| | M03F8.3 | Uncharacterized protein. (747 aa) |
| | prp-3 | Yeast PRP (Splicing factor) related. (621 aa) |
| | M01G5.1 | Uncharacterized protein. (891 aa) |
| | cey-3 | CSD_1 domain-containing protein. (265 aa) |
| | M01E11.2 | DUF1716 domain-containing protein. (544 aa) |
| | npp-3 | Nuclear Pore complex Protein. (1696 aa) |
| | rnp-2 | RNP (RRM RNA binding domain) containing. (206 aa) |
| | rnp-3 | RNP (RRM RNA binding domain) containing. (217 aa) |
| | K07F5.14 | Uncharacterized protein. (422 aa) |
| | npp-1 | Nup54 domain-containing protein. (639 aa) |
| | K07F5.12 | Uncharacterized protein. (351 aa) |
| | K07C5.6 | Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Belongs to the SLU7 family. (647 aa) |
| | syf-2 | Pre-mRNA-splicing factor syf-2; May be involved in pre-mRNA splicing. (234 aa) |
| | rnp-7 | RRM domain-containing protein. (332 aa) |
| | mog-1 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. (1131 aa) |
| | rnp-5 | RRM domain-containing protein. (289 aa) |
| | teg-4 | CPSF_A domain-containing protein. (1220 aa) |
| | K01G5.8 | Uncharacterized protein. (107 aa) |
| | rnf-113 | Probable E3 ubiquitin-protein ligase rnf113; May function as E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. May play a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit proteins involved in repair to sites of DNA damage by alkylating agents. (384 aa) |
| | rpb-5 | DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (211 aa) |
| | sacy-1 | Suppressor of ACY-4 sterility; Belongs to the DEAD box helicase family. (630 aa) |
| | mog-2 | Probable U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing. (253 aa) |
| | cyn-4 | Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development. (523 aa) |
| | clpf-1 | Protein clpf-1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (428 aa) |
| | tag-65 | SR-related CTD associated factor 6. (675 aa) |
| | rde-12 | DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1. (959 aa) |
| | rbm-17 | RNA Binding Motif protein homolog. (371 aa) |
| | F56G4.4 | U1-type domain-containing protein. (470 aa) |
| | ddx-15 | Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. (739 aa) |
| | cpf-2 | RRM domain-containing protein. (336 aa) |
| | npp-6 | Nuclear Pore complex Protein. (1562 aa) |
| | F54E4.4 | Uncharacterized protein. (487 aa) |
| | F53H1.1 | Uncharacterized protein. (970 aa) |
| | F53F4.14 | Sde2_N_Ubi domain-containing protein. (500 aa) |
| | isy-1 | Protein isy-1; Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10. Does not affect the splicing of zip-10 ; Belongs to the ISY1 family. (267 aa) |
| | mog-3 | Sex determining protein MOG-3. (451 aa) |
| | prp-17 | WD_REPEATS_REGION domain-containing protein. (567 aa) |
| | ubl-5 | Ubiquitin-like protein 5. (73 aa) |
| | cey-2 | CSD_1 domain-containing protein. (267 aa) |
| | vet-6 | Very Early Transcript. (843 aa) |
| | cfim-1 | Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa) |
| | F43G9.12 | GCFC domain-containing protein. (809 aa) |
| | mfap-1 | Microfibrillar-associated protein 1; Involved in pre-mRNA splicing. (466 aa) |
| | F43G6.5 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa) |
| | rpb-4 | RPOL4c domain-containing protein. (144 aa) |
| | hrp-1 | Heterogeneous nuclear ribonucleoprotein A1; This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan. (347 aa) |
| | pqn-37 | Prion-like-(Q/N-rich)-domain-bearing protein. (556 aa) |
| | irg-7 | Protein irg-7; Plays a role in innate immunity, probably via the atf-7 pathway, to confer resistance to pathogenic bacteria. May also play a role in the regulation of longevity. (2217 aa) |
| | sig-7 | Peptidyl-prolyl cis-trans isomerase sig-7; Probable PPIase that accelerates the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in RNA polymerase II (RNA pol II)-mediated transcription elongation, and in primary transcript splicing, including co-transcriptional trans- splicing, in association with the catalytic subunit of the RNA pol II complex ama-1. Also plays a role in the regulation of elongation-dependent phosphorylation of ama-1 to control transcription. Involved in the transc [...] (427 aa) |
| | ncbp-1 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa) |
| | F37C12.1 | Uncharacterized protein. (323 aa) |
| | F37A4.2 | Uncharacterized protein F37A4.2. (189 aa) |
| | ama-1 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa) |
| | F33H1.3 | Uncharacterized protein F33H1.3. (359 aa) |
| | F33D11.10 | Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa) |
| | cey-1 | CSD_1 domain-containing protein. (208 aa) |
| | let-858 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family. (897 aa) |
| | thoc-3 | WD_REPEATS_REGION domain-containing protein. (331 aa) |
| | spd-2 | Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment. (824 aa) |
| | fipp-1 | Fip1 domain-containing protein. (518 aa) |
| | F32B6.3 | SFM domain-containing protein. (352 aa) |
| | rsr-1 | PWI domain-containing protein. (601 aa) |
| | suf-1 | Suf domain-containing protein. (735 aa) |
| | cpf-1 | WD_REPEATS_REGION domain-containing protein. (430 aa) |
| | F28B4.3 | Uncharacterized protein. (2229 aa) |
| | rpb-8 | Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity); Belongs to the eukaryotic RPB8 RNA polymerase subunit family. (148 aa) |
| | hrpk-1 | Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response. (397 aa) |
| | ncbp-2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap stru [...] (158 aa) |
| | symk-1 | SYMpleKin cleavage and polyadenylation factor. (1143 aa) |
| | aly-2 | FoP_duplication domain-containing protein. (227 aa) |
| | rpb-12 | RNA Polymerase II (B) subunit. (62 aa) |
| | prpf-4 | Protein kinase domain-containing protein. (775 aa) |
| | F19F10.9 | Uncharacterized protein. (829 aa) |
| | F16A11.1 | Uncharacterized protein. (673 aa) |
| | F14F9.5 | Uncharacterized protein F14F9.5. (314 aa) |
| | cpsf-4 | Cleavage and Polyadenylation Specificity Factor. (302 aa) |
| | repo-1 | Matrin-type domain-containing protein. (222 aa) |
| | rae-1 | mRNA export factor rae-1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). It is specifically important for nuclear mRNA export. Has a role in neuronal development, where it acts downstream of rpm-1 to control axon termination and synapse formation in anterior lateral microtubule (ALM) and posterior lateral microtubule (PLM) mechanosensory neurons. Belo [...] (373 aa) |
| | kup-1 | Protein kup-1. (385 aa) |
| | cpsf-2 | Probable cleavage and polyadenylation specificity factor subunit 2; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. (843 aa) |
| | usp-39 | Ubiquitin Specific Protease. (602 aa) |
| | snrp-40.1 | WD_REPEATS_REGION domain-containing protein. (331 aa) |
| | F08B4.7 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (142 aa) |
| | npp-5 | Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import. (813 aa) |
| | lin-28 | Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. (227 aa) |
| | ddx-23 | DEAD boX helicase homolog; Belongs to the DEAD box helicase family. (730 aa) |
| | rsp-4 | Probable splicing factor, arginine/serine-rich 4; May play a functionally redundant role in embryogenesis. Belongs to the splicing factor SR family. (196 aa) |
| | mog-5 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5; Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. (1200 aa) |
| | EEED8.4 | Putative RNA-binding protein EEED8.4. (191 aa) |
| | EEED8.12 | Putative RNA-binding protein EEED8.12. (197 aa) |
| | let-504 | Nkap_C domain-containing protein. (504 aa) |
| | E01A2.2 | Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA- mediated gene silencing (RNAi) by miRNAs (By similarity). (712 aa) |
| | ptb-1 | Putative RNA-binding protein PTB-1a. (615 aa) |
| | rsp-7 | Probable splicing factor, arginine/serine-rich 7. (452 aa) |
| | cdc-5L | Cell Division Cycle related. (755 aa) |
| | plrg-1 | WD_REPEATS_REGION domain-containing protein. (494 aa) |
| | prp-38 | Yeast PRP (Splicing factor) related. (320 aa) |
| | cfim-2 | Cleavage Factor IM (CFIm) homolog. (491 aa) |
| | cyn-8 | Peptidyl-prolyl cis-trans isomerase 8; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (466 aa) |
| | smu-1 | Smu-1 suppressor of mec-8 and unc-52 protein; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site. In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18. (510 aa) |
| | snr-4 | Probable small nuclear ribonucleoprotein Sm D2; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). (118 aa) |
| | syf-1 | SYF pre-mRNA splicing factor homolog. (855 aa) |
| | C50D2.8 | Uncharacterized protein. (319 aa) |
| | C50D2.5 | Splicing factor 3B subunit 6-like protein; Necessary for the splicing of pre-mRNA. (138 aa) |
| | prp-8 | Pre-mRNA-splicing factor 8 homolog; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. (2329 aa) |
| | slrp-1 | RRM domain-containing protein. (114 aa) |
| | C47E8.4 | Protein FAM50 homolog; Belongs to the FAM50 family. (326 aa) |
| | C46F11.4 | Uncharacterized protein. (811 aa) |
| | hrpl-1 | Heterogeneous nuclear RibonucleoProtein (HnRNP) L homolog. (597 aa) |
| | acin-1 | ACINus (Mammalian Apoptotic Chromatin condensation Inducer in the Nucleus) homolog. (580 aa) |
| | C39E9.11 | Proline Rich mitotic Checkpoint Control factor homolog. (405 aa) |
| | C38C6.5 | Uncharacterized protein. (443 aa) |
| | prp-4 | WD_REPEATS_REGION domain-containing protein. (496 aa) |
