STRINGSTRING
his-20 his-20 lin-53 lin-53 gtf-2H1 gtf-2H1 htz-1 htz-1 his-4 his-4 his-1 his-1 chd-3 chd-3 gtf-2H2C gtf-2H2C tbp-1 tbp-1 T20D3.14 T20D3.14 his-67 his-67 lin-40 lin-40 Y104H12D.2 Y104H12D.2 Y104H12D.4 Y104H12D.4 rpb-10 rpb-10 rpoa-1 rpoa-1 cyh-1 cyh-1 Y50D4A.1 Y50D4A.1 xpd-1 xpd-1 gtf-2H5 gtf-2H5 xpb-1 xpb-1 his-28 his-28 Y73F8A.24 Y73F8A.24 gtf-2H3 gtf-2H3 his-26 his-26 his-10 his-10 his-11 his-11 his-14 his-14 his-15 his-15 gcna-1 gcna-1 his-48 his-48 his-46 his-46 rpb-6 rpb-6 rpoa-12 rpoa-12 nra-3 nra-3 dcp-66 dcp-66 mbd-2 mbd-2 C36E8.1 C36E8.1 his-41 his-41 his-37 his-37 his-54 his-54 his-52 his-52 his-50 his-50 his-44 his-44 rpoa-2 rpoa-2 his-31 his-31 his-34 his-34 his-64 his-64 rpb-12 rpb-12 let-418 let-418 rpb-8 rpb-8 his-29 his-29 tlf-1 tlf-1 his-8 his-8 his-39 his-39 his-5 his-5 mnat-1 mnat-1 csb-1 csb-1 F53H4.6 F53H4.6 his-56 his-56 his-58 his-58 his-60 his-60 his-62 his-62 his-66 his-66 rpb-5 rpb-5 rpac-40 rpac-40 his-38 his-38 his-18 his-18 his-22 his-22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-20Histone H2B 2. (123 aa)
lin-53Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repres [...] (417 aa)
gtf-2H1General Transcription Factor homolog. (532 aa)
htz-1Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal [...] (140 aa)
his-4Histone H2B 2. (123 aa)
his-1Histone H4. (103 aa)
chd-3Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. (1787 aa)
gtf-2H2CGeneral transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (376 aa)
tbp-1TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (340 aa)
T20D3.14Uncharacterized protein. (91 aa)
his-67Histone H4. (103 aa)
lin-40Uncharacterized protein. (1022 aa)
Y104H12D.2Uncharacterized protein. (327 aa)
Y104H12D.4Uncharacterized protein. (107 aa)
rpb-10DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the cor [...] (67 aa)
rpoa-1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1737 aa)
cyh-1CYclin H. (332 aa)
Y50D4A.1Uncharacterized protein. (821 aa)
xpd-1Helicase ATP-binding domain-containing protein. (755 aa)
gtf-2H5General Transcription Factor homolog. (71 aa)
xpb-1XPB (Xeroderma Pigmentosum complementation group B) related. (789 aa)
his-28Histone H4. (103 aa)
Y73F8A.24General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (485 aa)
gtf-2H3General Transcription Factor homolog. (296 aa)
his-26Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-11Histone H2B 1. (122 aa)
his-14Histone H4. (103 aa)
his-15Histone H2B 1. (122 aa)
gcna-1SprT-like domain-containing protein. (532 aa)
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
rpb-6Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of t [...] (137 aa)
rpoa-12DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (119 aa)
nra-3PHD-type domain-containing protein. (925 aa)
dcp-66Deacetylase Complex Protein. (724 aa)
mbd-2MBD_C domain-containing protein. (210 aa)
C36E8.1Uncharacterized protein C36E8.1; Belongs to the RRN3 family. (654 aa)
his-41Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-37Histone H4. (103 aa)
his-54Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-52Histone H2B 2. (123 aa)
his-50Histone H4. (103 aa)
his-44Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa)
rpoa-2DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1127 aa)
his-31Histone H4. (103 aa)
his-34Histone H2B 1. (122 aa)
his-64Histone H4. (103 aa)
rpb-12RNA Polymerase II (B) subunit. (62 aa)
let-418Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] (1829 aa)
rpb-8Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity); Belongs to the eukaryotic RPB8 RNA polymerase subunit family. (148 aa)
his-29Histone H2B 1. (122 aa)
tlf-1TBP-Like Factor. (508 aa)
his-8Histone H2B 2. (123 aa)
his-39Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
his-5Histone H4. (103 aa)
mnat-1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (310 aa)
csb-1CSB (Cockayne Syndrome B) homolog. (957 aa)
F53H4.6Helicase C-terminal domain-containing protein. (933 aa)
his-56Histone H4. (103 aa)
his-58Probable histone H2B 4. (123 aa)
his-60Histone H4. (103 aa)
his-62Probable histone H2B 4. (123 aa)
his-66Probable histone H2B 4. (123 aa)
rpb-5DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (211 aa)
rpac-40RPOLD domain-containing protein. (366 aa)
his-38Histone H4. (103 aa)
his-18Histone H4. (103 aa)
his-22Histone H2B 2. (123 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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