STRINGSTRING
thoc-7 thoc-7 aly-1 aly-1 C02B10.4 C02B10.4 thoc-2 thoc-2 pabp-2 pabp-2 hel-1 hel-1 rsp-6 rsp-6 C38C6.5 C38C6.5 C49H3.4 C49H3.4 cfim-2 cfim-2 rsp-7 rsp-7 EEED8.12 EEED8.12 EEED8.4 EEED8.4 cpsf-2 cpsf-2 kup-1 kup-1 cpsf-4 cpsf-4 aly-2 aly-2 symk-1 symk-1 ncbp-2 ncbp-2 cpf-1 cpf-1 suf-1 suf-1 rsr-1 rsr-1 fipp-1 fipp-1 thoc-3 thoc-3 F33D11.10 F33D11.10 ncbp-1 ncbp-1 F43G6.5 F43G6.5 cfim-1 cfim-1 prp-17 prp-17 cpf-2 cpf-2 clpf-1 clpf-1 rnp-5 rnp-5 mog-1 mog-1 K07A1.15 K07A1.15 K07C5.6 K07C5.6 aly-3 aly-3 M88.4 M88.4 pfs-2 pfs-2 R06C1.4 R06C1.4 cdl-1 cdl-1 rnp-4 rnp-4 rbm-3.1 rbm-3.1 rbm-3.2 rbm-3.2 mag-1 mag-1 pcf-11 pcf-11 thoc-1 thoc-1 T08B6.1 T08B6.1 sgnh-1 sgnh-1 T08B6.9 T08B6.9 drr-2 drr-2 T15H9.6 T15H9.6 rsp-5 rsp-5 rsp-2 rsp-2 rsp-1 rsp-1 W08E3.2 W08E3.2 rsp-3 rsp-3 uaf-2 uaf-2 snr-1 snr-1 pap-1 pap-1 thoc-5 thoc-5 Y37E11AL.9 Y37E11AL.9 Y47G6A.26 Y47G6A.26 snr-6 snr-6 Y51H4A.22 Y51H4A.22 Y51H4A.23 Y51H4A.23 Y53G8AR.6 Y53G8AR.6 Y54G2A.12 Y54G2A.12 Y57G11A.5 Y57G11A.5 cpsf-3 cpsf-3 Y71F9AL.12 Y71F9AL.12 snr-7 snr-7 cpsf-1 cpsf-1 Y82E9BR.2 Y82E9BR.2 uaf-1 uaf-1 ZK1128.3 ZK1128.3 ZK1225.4 ZK1225.4 ZK1225.5 ZK1225.5 ZK131.11 ZK131.11 snr-5 snr-5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
thoc-7THO Complex (Transcription factor/nuclear export) subunit. (210 aa)
aly-1FoP_duplication domain-containing protein. (223 aa)
C02B10.4RRM domain-containing protein. (211 aa)
thoc-2THO Complex (Transcription factor/nuclear export) subunit. (1437 aa)
pabp-2RRM domain-containing protein. (205 aa)
hel-1Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly. (425 aa)
rsp-6Probable splicing factor, arginine/serine-rich 6; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood; Belongs to the splicing factor SR family. (179 aa)
C38C6.5Uncharacterized protein. (443 aa)
C49H3.4Sm domain-containing protein. (223 aa)
cfim-2Cleavage Factor IM (CFIm) homolog. (491 aa)
rsp-7Probable splicing factor, arginine/serine-rich 7. (452 aa)
EEED8.12Putative RNA-binding protein EEED8.12. (197 aa)
EEED8.4Putative RNA-binding protein EEED8.4. (191 aa)
cpsf-2Probable cleavage and polyadenylation specificity factor subunit 2; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. (843 aa)
kup-1Protein kup-1. (385 aa)
cpsf-4Cleavage and Polyadenylation Specificity Factor. (302 aa)
aly-2FoP_duplication domain-containing protein. (227 aa)
symk-1SYMpleKin cleavage and polyadenylation factor. (1143 aa)
ncbp-2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap stru [...] (158 aa)
cpf-1WD_REPEATS_REGION domain-containing protein. (430 aa)
suf-1Suf domain-containing protein. (735 aa)
rsr-1PWI domain-containing protein. (601 aa)
fipp-1Fip1 domain-containing protein. (518 aa)
thoc-3WD_REPEATS_REGION domain-containing protein. (331 aa)
F33D11.10Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa)
ncbp-1Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...] (798 aa)
F43G6.5Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa)
cfim-1Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
prp-17WD_REPEATS_REGION domain-containing protein. (567 aa)
cpf-2RRM domain-containing protein. (336 aa)
clpf-1Protein clpf-1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily. (428 aa)
rnp-5RRM domain-containing protein. (289 aa)
mog-1Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. (1131 aa)
K07A1.15Sm domain-containing protein. (122 aa)
K07C5.6Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Belongs to the SLU7 family. (647 aa)
aly-3FoP_duplication domain-containing protein. (240 aa)
M88.4PID domain-containing protein. (365 aa)
pfs-2pre-mRNA 3' end processing protein pfs-2; Essential for both cleavage and polyadenylation of pre-mRNA 3' ends (By similarity). Involved in neuron development, probably by regulating pre-mRNA 3'-end processing. (820 aa)
R06C1.4RRM domain-containing protein. (84 aa)
cdl-1Histone RNA hairpin-binding protein; Involved in histone pre-mRNA 3' processing. Required for chromosome condensation, progression of cell death and morphogenesis. (382 aa)
rnp-4RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (142 aa)
rbm-3.1RRM domain-containing protein. (83 aa)
rbm-3.2RRM domain-containing protein. (85 aa)
mag-1Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family. (152 aa)
pcf-11Polyadenylation and cleavage factor homolog 11. (823 aa)
thoc-1THO Complex (Transcription factor/nuclear export) subunit. (665 aa)
T08B6.1Uncharacterized protein. (96 aa)
sgnh-1RRM domain-containing protein. (177 aa)
T08B6.9Uncharacterized protein. (531 aa)
drr-2RRM domain-containing protein. (207 aa)
T15H9.6Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa)
rsp-5Probable splicing factor, arginine/serine-rich 5; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites. (208 aa)
rsp-2Probable splicing factor, arginine/serine-rich 2; Plays a functionally redundant role in spermatogenesis and growth rate control. Required for the development of somatic gonad structures and for progression from larval stage to adulthood. Belongs to the splicing factor SR family. (281 aa)
rsp-1Probable splicing factor, arginine/serine-rich 1; Plays a functionally redundant role in spermatogenesis and growth rate control. (312 aa)
W08E3.2Btz domain-containing protein. (584 aa)
rsp-3Probable splicing factor, arginine/serine-rich 3; Plays an essential role in embryogenesis. (258 aa)
uaf-2U2AF splicing factor. (285 aa)
snr-1Small nuclear ribonucleoprotein Sm D3; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity); Belongs to the snRNP core protein family. (136 aa)
pap-1Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (655 aa)
thoc-5THO Complex (Transcription factor/nuclear export) subunit. (599 aa)
Y37E11AL.9Uncharacterized protein. (133 aa)
Y47G6A.26Uncharacterized protein. (196 aa)
snr-6Probable small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (90 aa)
Y51H4A.22Uncharacterized protein. (283 aa)
Y51H4A.23Uncharacterized protein. (257 aa)
Y53G8AR.6SAP domain-containing protein. (253 aa)
Y54G2A.12WD_REPEATS_REGION domain-containing protein. (274 aa)
Y57G11A.5RRM domain-containing protein. (110 aa)
cpsf-3Cleavage and Polyadenylation Specificity Factor. (707 aa)
Y71F9AL.12Uncharacterized protein. (289 aa)
snr-7Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (77 aa)
cpsf-1Probable cleavage and polyadenylation specificity factor subunit 1; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). (1454 aa)
Y82E9BR.2Uncharacterized protein. (530 aa)
uaf-1Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity). (496 aa)
ZK1128.3Uncharacterized protein ZK1128.3. (360 aa)
ZK1225.4Uncharacterized protein. (519 aa)
ZK1225.5Uncharacterized protein. (511 aa)
ZK131.11Uncharacterized protein. (449 aa)
snr-5Probable small nuclear ribonucleoprotein F; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. (85 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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