STRINGSTRING
cdc-48.1 cdc-48.1 kxd-1 kxd-1 C39E9.12 C39E9.12 rfc-3 rfc-3 cdc-48.2 cdc-48.2 rfc-1 rfc-1 glo-4 glo-4 pole-2 pole-2 F10C2.4 F10C2.4 F12F6.7 F12F6.7 rpa-1 rpa-1 ufd-1 ufd-1 polk-1 polk-1 ubq-1 ubq-1 rfc-4 rfc-4 pole-1 pole-1 F34H10.1 F34H10.1 wdr-48 wdr-48 mdt-30 mdt-30 F44B9.8 F44B9.8 cul-4 cul-4 F52C6.2 F52C6.2 F52C6.3 F52C6.3 polh-1 polh-1 rfc-2 rfc-2 ubl-1 ubl-1 cdc-48.3 cdc-48.3 sdz-24 sdz-24 K08C9.7 K08C9.7 ddb-1 ddb-1 R03H10.6 R03H10.6 R03H10.7 R03H10.7 cdt-2 cdt-2 dvc-1 dvc-1 T26A5.8 T26A5.8 pcn-1 pcn-1 Y37B11A.2 Y37B11A.2 Y53F4B.3 Y53F4B.3 Y53F4B.9 Y53F4B.9 ubq-2 ubq-2 rbx-1 rbx-1 rev-1 rev-1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
cdc-48.1Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa)
kxd-1KxDL domain-containing protein. (140 aa)
C39E9.12SAP domain-containing protein. (409 aa)
rfc-3RFC (DNA replication factor) family. (354 aa)
cdc-48.2Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] (810 aa)
rfc-1Replication factor C subunit 1. (839 aa)
glo-4X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons. (1386 aa)
pole-2Probable DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (521 aa)
F10C2.4DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity). (1081 aa)
F12F6.7Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family. (451 aa)
rpa-1Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (655 aa)
ufd-1Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway (By similarity). In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradati [...] (342 aa)
polk-1DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). Belongs to the DNA polymerase type-Y family. (596 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
rfc-4Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity). (334 aa)
pole-1DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2144 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
wdr-48WD repeat-containing protein 48 homolog; Together with wdr-20, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor. (697 aa)
mdt-30Glutamine/asparagine-rich protein mdt-30. (466 aa)
F44B9.8Probable replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. (368 aa)
cul-4Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1. (840 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
polh-1UmuC domain-containing protein. (584 aa)
rfc-2AAA domain-containing protein. (334 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
cdc-48.3ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into she [...] (724 aa)
sdz-24OB domain-containing protein. (236 aa)
K08C9.7Uncharacterized protein. (154 aa)
ddb-1DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division. (1134 aa)
R03H10.6REPA_OB_2 domain-containing protein. (324 aa)
R03H10.7REPA_OB_2 domain-containing protein. (359 aa)
cdt-2WD_REPEATS_REGION domain-containing protein. (682 aa)
dvc-1SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: required to protect genome stability during DNA replication, possibly via recruitment of vcp/p97 (cdc-48.1 or cdc-48.2) recruitment. Belongs to the Spartan family. (368 aa)
T26A5.8CBFD_NFYB_HMF domain-containing protein. (137 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
Y37B11A.2DNA polymerase. (1303 aa)
Y53F4B.3CBFD_NFYB_HMF domain-containing protein. (179 aa)
Y53F4B.9Uncharacterized protein. (1168 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
rbx-1RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa)
rev-1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1027 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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