50 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZK822.1	Uncharacterized protein. (913 aa)
	acs-15	Fatty Acid CoA Synthetase family. (703 aa)
	acs-18	AMP-binding domain-containing protein. (700 aa)
	R10E4.9	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (202 aa)
	R11G11.6	DUF148 domain-containing protein. (146 aa)
	pqn-60	DUF148 domain-containing protein. (154 aa)
	acs-3	AMP-binding domain-containing protein. (653 aa)
	hpo-8	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precu [...] (218 aa)
	fat-6	Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
	fat-5	Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
	Y37B11A.3	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (125 aa)
	dhs-11	DeHydrogenases, Short chain. (244 aa)
	elo-8	Elongation of very long chain fatty acids protein. (292 aa)
	elo-9	Elongation of very long chain fatty acids protein. (286 aa)
	acs-13	AMP-binding domain-containing protein. (726 aa)
	acs-5	Fatty Acid CoA Synthetase family. (687 aa)
	morc-1	Protein morc-1; Involved in gene silencing. Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes. May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes. Promotes transgenerational epigenetic inheritance and germline immortality. (845 aa)
	ZC204.1	DUF148 domain-containing protein. (149 aa)
	pqn-97	DUF148 domain-containing protein. (156 aa)
	pqn-98	DUF148 domain-containing protein. (159 aa)
	K11H3.3	Putative tricarboxylate transport protein, mitochondrial; Transport of citrate across inner mitochondrial membrane. Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
	ZK822.4	DUF148 domain-containing protein. (453 aa)
	acly-2	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1099 aa)
	acs-4	Fatty Acid CoA Synthetase family. (731 aa)
	F32H2.6	Ketoacyl_synth_N domain-containing protein. (187 aa)
	fasn-1	Carrier domain-containing protein. (2613 aa)
	stdh-4	Putative steroid dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (317 aa)
	F13E9.14	DUF148 domain-containing protein. (222 aa)
	elo-2	Elongation of very long chain fatty acids protein. (274 aa)
	stdh-2	Putative steroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa)
	fat-7	Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
	dhs-25	DeHydrogenases, Short chain. (248 aa)
	elo-3	Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family. (320 aa)
	acly-1	Probable ATP-citrate synthase; ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1106 aa)
	let-767	Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (337 aa)
	acs-21	Fatty Acid CoA Synthetase family. (517 aa)
	acs-17	Fatty Acid CoA Synthetase family. (718 aa)
	pks-1	PolyKetide Synthase. (7752 aa)
	elo-4	Putative fatty acid elongation protein 4; Could be implicated in synthesis of very long chain fatty acids; Belongs to the ELO family. (291 aa)
	art-1	Probable very-long-chain enoyl-CoA reductase art-1; Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precurso [...] (308 aa)
	stdh-3	Putative steroid dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa)
	stdh-1	Putative steroid dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (314 aa)
	dhs-27	Uncharacterized oxidoreductase dhs-27. (320 aa)
	acs-11	Fatty Acid CoA Synthetase family. (505 aa)
	elo-5	Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family. (274 aa)
	elo-6	Elongation of very long chain fatty acids protein 6; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isoheptadecanoate (C17iso). (274 aa)
	ppt-1	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides. (298 aa)
	dhs-5	Uncharacterized oxidoreductase dhs-5. (378 aa)
	elo-7	Elongation of very long chain fatty acids protein. (309 aa)
	elo-1	Elongation of very long chain fatty acids protein. (288 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F13E9.14	F32H2.6	F13E9.14.1	F32H2.6.1	DUF148 domain-containing protein.	Ketoacyl_synth_N domain-containing protein.	0.453
F13E9.14	fasn-1	F13E9.14.1	F32H2.5.1	DUF148 domain-containing protein.	Carrier domain-containing protein.	0.453
F13E9.14	pks-1	F13E9.14.1	C41A3.1a.1	DUF148 domain-containing protein.	PolyKetide Synthase.	0.470
F32H2.6	F13E9.14	F32H2.6.1	F13E9.14.1	Ketoacyl_synth_N domain-containing protein.	DUF148 domain-containing protein.	0.453
F32H2.6	K11H3.3	F32H2.6.1	K11H3.3.1	Ketoacyl_synth_N domain-containing protein.	Putative tricarboxylate transport protein, mitochondrial; Transport of citrate across inner mitochondrial membrane. Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.755
F32H2.6	R11G11.6	F32H2.6.1	R11G11.6.1	Ketoacyl_synth_N domain-containing protein.	DUF148 domain-containing protein.	0.453
F32H2.6	ZC204.1	F32H2.6.1	ZC204.1.1	Ketoacyl_synth_N domain-containing protein.	DUF148 domain-containing protein.	0.453
F32H2.6	ZK822.1	F32H2.6.1	ZK822.1.1	Ketoacyl_synth_N domain-containing protein.	Uncharacterized protein.	0.453
F32H2.6	ZK822.4	F32H2.6.1	ZK822.4.1	Ketoacyl_synth_N domain-containing protein.	DUF148 domain-containing protein.	0.453
F32H2.6	acly-1	F32H2.6.1	D1005.1.1	Ketoacyl_synth_N domain-containing protein.	Probable ATP-citrate synthase; ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.883
F32H2.6	acly-2	F32H2.6.1	B0365.1.1	Ketoacyl_synth_N domain-containing protein.	ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.	0.670
F32H2.6	acs-11	F32H2.6.1	F41C3.3.2	Ketoacyl_synth_N domain-containing protein.	Fatty Acid CoA Synthetase family.	0.553
F32H2.6	acs-21	F32H2.6.1	C50H11.1.1	Ketoacyl_synth_N domain-containing protein.	Fatty Acid CoA Synthetase family.	0.553
F32H2.6	dhs-11	F32H2.6.1	Y39A1A.11a.1	Ketoacyl_synth_N domain-containing protein.	DeHydrogenases, Short chain.	0.478
F32H2.6	dhs-25	F32H2.6.1	F09E10.3.1	Ketoacyl_synth_N domain-containing protein.	DeHydrogenases, Short chain.	0.572
F32H2.6	dhs-27	F32H2.6.1	C04F6.5.1	Ketoacyl_synth_N domain-containing protein.	Uncharacterized oxidoreductase dhs-27.	0.527
F32H2.6	dhs-5	F32H2.6.1	F56D1.5.1	Ketoacyl_synth_N domain-containing protein.	Uncharacterized oxidoreductase dhs-5.	0.502
F32H2.6	elo-1	F32H2.6.1	F56H11.4a.1	Ketoacyl_synth_N domain-containing protein.	Elongation of very long chain fatty acids protein.	0.415
F32H2.6	elo-3	F32H2.6.1	D2024.3.1	Ketoacyl_synth_N domain-containing protein.	Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family.	0.688
F32H2.6	elo-4	F32H2.6.1	C40H1.4.1	Ketoacyl_synth_N domain-containing protein.	Putative fatty acid elongation protein 4; Could be implicated in synthesis of very long chain fatty acids; Belongs to the ELO family.	0.473