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| | T28C12.1 | MFS domain-containing protein. (474 aa) |
| | age-1 | Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...] (1182 aa) |
| | tpa-1 | Protein kinase C-like 1; Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp- 29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir- 1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in phary [...] (704 aa) |
| | unc-78 | Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils. (611 aa) |
| | hpo-9 | BTB domain-containing protein. (581 aa) |
| | rap-3 | RAP homolog (Vertebrate Rap GTPase family). (205 aa) |
| | unc-89 | Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa) |
| | dgk-1 | Diacylglycerol kinase. (952 aa) |
| | str-130 | Seven TM Receptor. (338 aa) |
| | C12D5.10 | Uncharacterized protein. (357 aa) |
| | sem-5 | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] (228 aa) |
| | srsx-34 | Serpentine Receptor, class SX. (491 aa) |
| | C25E10.4 | Uncharacterized protein. (486 aa) |
| | C25E10.5 | Uncharacterized protein. (492 aa) |
| | tsp-9 | Tetraspanin. (233 aa) |
| | rap-1 | Ras-related protein Rap-1; Required in the hypodermis for proper formation of the cuticle; Belongs to the small GTPase superfamily. Ras family. (188 aa) |
| | nex-3 | Annexin. (317 aa) |
| | spp-8 | SaPosin-like Protein family. (402 aa) |
| | spp-10 | SaPosin-like Protein family. (429 aa) |
| | C34F6.10 | Uncharacterized protein. (1465 aa) |
| | vav-1 | Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis. (1007 aa) |
| | unc-60 | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. (152 aa) |
| | cps-6 | Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation. (308 aa) |
| | apl-1 | Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...] (686 aa) |
| | chil-10 | Glyco_hydro_18 domain-containing protein. (371 aa) |
| | cpn-2 | Transgelin; Belongs to the calponin family. (203 aa) |
| | pkc-2 | Protein kinase C-like 2; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (936 aa) |
| | gpc-2 | G protein gamma domain-containing protein. (62 aa) |
| | tth-1 | Thymosin beta; Plays an important role in the organization of the cytoskeleton by regulating actin polymerization in two ways. Firstly, by binding to and sequestering actin monomers (G actin) inhibits actin polymerization. Secondly, by binding directly filamentous actin (F actin) promotes actin polymerization. Regulates the formation of cortical actin in oocytes conferring them enough rigidity to sustain the contractions during ovulation. (151 aa) |
| | mig-10 | Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family. (779 aa) |
| | gpb-1 | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa) |
| | F14D7.6 | MFS domain-containing protein. (487 aa) |
| | gpa-12 | Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families. Upstream of plc-3, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. (355 aa) |
| | ldp-1 | Lipid droplet localized protein; Belongs to the saccharopine dehydrogenase family. (426 aa) |
| | F22F7.2 | Sacchrp_dh_NADP domain-containing protein. (422 aa) |
| | F26H9.2 | Uncharacterized protein. (508 aa) |
| | unc-18 | Putative acetylcholine regulator unc-18; May participate in the axonal transport system and influences the acetylcholine flow in motor neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt ; Belongs to the STXBP/unc-18/SEC1 family. (591 aa) |
| | F27D9.2 | MFS domain-containing protein. (498 aa) |
| | F31C3.6 | Uncharacterized protein. (554 aa) |
| | tsp-8 | Tetraspanin. (282 aa) |
| | itr-1 | Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa) |
| | F35G2.1 | Sulfhydryl oxidase. (601 aa) |
| | dgk-4 | Diacylglycerol kinase. (1339 aa) |
| | dagl-2 | Lipase_3 domain-containing protein. (683 aa) |
| | cpn-1 | Calponin-homology (CH) domain-containing protein. (192 aa) |
| | dgk-2 | Diacylglycerol kinase. (536 aa) |
| | F47B7.2 | Sulfhydryl oxidase. (678 aa) |
| | F48G7.10 | Uncharacterized protein. (168 aa) |
| | F48G7.9 | Phorbol-ester/DAG-type domain-containing protein. (125 aa) |
| | gpb-2 | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa) |
| | F52F10.2 | Uncharacterized protein. (508 aa) |
| | tsp-4 | Tetraspanin. (241 aa) |
| | unc-60-2 | Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87. (165 aa) |
| | dgk-3 | Probable diacylglycerol kinase 3; Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels. Belongs to the eukaryotic diacylglycerol kinase family. (795 aa) |
| | vig-1 | HABP4_PAI-RBP1 domain-containing protein. (378 aa) |
| | F57A8.7 | Uncharacterized protein. (487 aa) |
| | pkc-1 | Protein kinase C-like 1B; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Involved in neuropeptide secretion in motor axons. Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in the signaling response to various sensory neurons; temperature, odor, taste, and osmolality. Its role in regulation differs depending on the neuron in which it is acting; thermosensation in AFD neurons, osmolality in ASH neuro [...] (763 aa) |
| | F58G11.4 | Uncharacterized protein. (464 aa) |
| | cdh-9 | CaDHerin family. (623 aa) |
| | tsp-18 | TetraSPanin family. (473 aa) |
| | ptp-2 | Tyrosine-protein phosphatase non-receptor type ptp-2; Involved in embryonic and larval development. Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15. Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1. Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23. N [...] (668 aa) |
| | pdk-1 | 3-phosphoinositide-dependent protein kinase 1; Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. (636 aa) |
| | gpc-1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa) |
| | moma-1 | MICOS complex subunit MIC27; Sustains mitochondrial morphology probably through maintaining cristae morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity). (201 aa) |
| | dgk-5 | Putative diacylglycerol kinase K06A1.6. (1150 aa) |
| | aipl-1 | WD_REPEATS_REGION domain-containing protein. (600 aa) |
| | egl-30 | Heterotrimeric G protein alpha subunit. (355 aa) |
| | R07G3.8 | Uncharacterized protein. (334 aa) |
| | chil-14 | CHItinase-Like. (388 aa) |
| | R12G8.1 | Uncharacterized protein. (164 aa) |
| | mfsd-6 | MFS_1_like domain-containing protein. (630 aa) |
| | ten-1 | Teneurin-1; Plays a role in the gonadal basement membrane maintenance and/or adhesion early in development. Contributes to the guidance of pharyngeal neurons. (2837 aa) |
| | T04H1.2 | Tr-type G domain-containing protein. (588 aa) |
| | T07A9.10 | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (562 aa) |
| | nex-2 | Annexin. (497 aa) |
| | lev-9 | Protein lev-9; Scaffolding protein that is necessary to cluster acetylcholine receptors at neuromuscular junctions. (1347 aa) |
| | T10H10.2 | Sulfhydryl oxidase. (574 aa) |
| | epac-1 | Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1. (1038 aa) |
| | tsp-7 | Tetraspanin. (232 aa) |
| | T28C12.2 | MFS domain-containing protein. (485 aa) |
| | W01B6.3 | Uncharacterized protein. (484 aa) |
| | W03C9.6 | Uncharacterized protein. (500 aa) |
| | W04B5.5 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (320 aa) |
| | W05E10.1 | MFS domain-containing protein. (484 aa) |
| | W07A12.4 | BTB domain-containing protein. (528 aa) |
| | ola-1 | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. (395 aa) |
| | aap-1 | Phosphoinositide 3-kinase adapter subunit. (522 aa) |
| | Y111B2A.12 | WD_REPEATS_REGION domain-containing protein. (417 aa) |
| | cgp-1 | GTP-binding protein cgp-1; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily. (613 aa) |
| | tsp-5 | Tetraspanin. (241 aa) |
| | Y50D4B.2 | Uncharacterized protein. (251 aa) |
| | Y53G8AR.7 | MFS domain-containing protein. (519 aa) |
| | manf-1 | Mesencephalic astrocyte-derived neurotrophic factor homolog; Inhibits endoplasmic reticulum (ER) stress response (By similarity). Retained in the ER under normal conditions and is up- regulated and secreted by the ER in response to ER stress and hypoxia (By similarity). Following secretion by the ER, directly binds to 3-O- sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions (By similarity). Has a neuroprotecti [...] (168 aa) |
| | tln-1 | Talin. (2553 aa) |
| | abhd-12 | Hydrolase_4 domain-containing protein. (345 aa) |
| | nex-1 | Annexin. (322 aa) |
| | deb-1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa) |
| | ZK550.2 | MFS domain-containing protein. (502 aa) |
| | ZK973.11 | Thioredoxin domain-containing protein. (447 aa) |
