STRINGSTRING
unc-30 unc-30 C29F9.5 C29F9.5 C29F9.6 C29F9.6 C49F5.5 C49F5.5 DC2.5 DC2.5 E04F6.15 E04F6.15 dhs-7 dhs-7 lex-1 lex-1 F22F1.3 F22F1.3 srh-255 srh-255 aptf-4 aptf-4 aptf-3 aptf-3 ubc-9 ubc-9 F29B9.8 F29B9.8 srh-266 srh-266 F32A5.8 F32A5.8 cbp-3 cbp-3 uev-2 uev-2 cbp-2 cbp-2 aptf-1 aptf-1 dhs-8 dhs-8 K10H10.6 K10H10.6 smo-1 smo-1 gfl-1 gfl-1 cbp-1 cbp-1 srh-257 srh-257 srh-258 srh-258 srh-264 srh-264 srh-265 srh-265 Y105E8B.7 Y105E8B.7 aptf-2 aptf-2 ZK1010.10 ZK1010.10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
unc-30Homeobox protein unc-30; Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid- secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of gene [...] (323 aa)
C29F9.5Uncharacterized protein. (261 aa)
C29F9.6TAZ-type domain-containing protein. (240 aa)
C49F5.5TAZ-type domain-containing protein. (151 aa)
DC2.5Uncharacterized protein. (337 aa)
E04F6.15Uncharacterized protein. (319 aa)
dhs-7DeHydrogenases, Short chain. (329 aa)
lex-1Tat-binding homolog 7; Thought to form a complex that enhances transcription from repetitive DNA sequences by modulating chromatin structure. Belongs to the AAA ATPase family. (1291 aa)
F22F1.3Uncharacterized protein. (245 aa)
srh-255Serpentine Receptor, class H. (329 aa)
aptf-4TF_AP-2 domain-containing protein. (486 aa)
aptf-3TF_AP-2 domain-containing protein. (535 aa)
ubc-9SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
F29B9.8Uncharacterized protein. (381 aa)
srh-266Serpentine Receptor, class H. (327 aa)
F32A5.8Uncharacterized protein. (257 aa)
cbp-3TAZ-type domain-containing protein. (199 aa)
uev-2UBIQUITIN_CONJUGAT_2 domain-containing protein. (230 aa)
cbp-2CBP/p300 homolog. (322 aa)
aptf-1Transcription factor aptf-1; Transcription factor, which is required in the single sleep- active ring interneuron RIS for sleep-like behavioral quiescence induced by neuropeptide signaling in larvae. Regulates gene expression of sleep-inducing FMRFamide-like neuropeptide flp-11 in RIS. (365 aa)
dhs-8DeHydrogenases, Short chain. (379 aa)
K10H10.6Uncharacterized protein. (315 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
gfl-1GAS41-Like. (211 aa)
cbp-1Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa)
srh-257Serpentine Receptor, class H. (329 aa)
srh-258Serpentine Receptor, class H. (334 aa)
srh-264Serpentine Receptor, class H. (333 aa)
srh-265Serpentine Receptor, class H. (334 aa)
Y105E8B.7Uncharacterized protein. (269 aa)
aptf-2TF_AP-2 domain-containing protein. (367 aa)
ZK1010.10TAZ-type domain-containing protein. (194 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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