STRINGSTRING
F32D8.14 F32D8.14 leo-1 leo-1 his-48 his-48 ctr-9 ctr-9 kxd-1 kxd-1 zipt-13 zipt-13 C25F9.4 C25F9.4 C25F9.5 C25F9.5 prx-5 prx-5 C34F6.7 C34F6.7 ubc-1 ubc-1 C35B1.2 C35B1.2 his-41 his-41 pafo-1 pafo-1 F02E9.10 F02E9.10 his-54 his-54 his-52 his-52 prx-12 prx-12 his-44 his-44 his-34 his-34 rtfo-1 rtfo-1 ubq-1 ubq-1 prx-13 prx-13 F34H10.1 F34H10.1 cdc-73 cdc-73 his-29 his-29 uev-1 uev-1 his-8 his-8 his-39 his-39 F52C6.2 F52C6.2 F52C6.3 F52C6.3 his-58 his-58 his-62 his-62 his-66 his-66 ubl-1 ubl-1 his-22 his-22 his-20 his-20 K08C9.7 K08C9.7 M04C3.1 M04C3.1 M04C3.2 M04C3.2 rfp-1 rfp-1 prx-14 prx-14 T05A12.4 T05A12.4 his-4 his-4 pcn-1 pcn-1 Y104H12D.2 Y104H12D.2 Y104H12D.4 Y104H12D.4 Y40B1A.2 Y40B1A.2 Y43F8B.14 Y43F8B.14 ubc-13 ubc-13 ubq-2 ubq-2 ZK1098.1 ZK1098.1 his-11 his-11 his-15 his-15 prx-2 prx-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F32D8.14Protein YIPF. (261 aa)
leo-1RNA polymerase-associated protein LEO1; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification. (430 aa)
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
ctr-9RNA polymerase-associated protein CTR9; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification (By similarity). Ctr-9 is required for epidermal microtubule organization during morphogenesis. (1150 aa)
kxd-1KxDL domain-containing protein. (140 aa)
zipt-13Zrt (ZRT), Irt-(IRT-) like Protein Transporter. (353 aa)
C25F9.4SNF2_N domain-containing protein. (592 aa)
C25F9.5Uncharacterized protein. (713 aa)
prx-5TPR_REGION domain-containing protein. (502 aa)
C34F6.7Uncharacterized protein. (411 aa)
ubc-1Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
C35B1.2Uncharacterized protein. (562 aa)
his-41Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
pafo-1RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification. (425 aa)
F02E9.10WD_REPEATS_REGION domain-containing protein. (455 aa)
his-54Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-52Histone H2B 2. (123 aa)
prx-12Putative peroxisome assembly protein 12; Required for protein import into peroxisomes; Belongs to the pex2/pex10/pex12 family. (344 aa)
his-44Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa)
his-34Histone H2B 1. (122 aa)
rtfo-1RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification. (613 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
prx-13Probable peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5) (By similarity); Belongs to the peroxin-13 family. (330 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
cdc-73Cell division cycle protein 73; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification; Belongs to the CDC73 family. (517 aa)
his-29Histone H2B 1. (122 aa)
uev-1Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...] (139 aa)
his-8Histone H2B 2. (123 aa)
his-39Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
his-58Probable histone H2B 4. (123 aa)
his-62Probable histone H2B 4. (123 aa)
his-66Probable histone H2B 4. (123 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
his-22Histone H2B 2. (123 aa)
his-20Histone H2B 2. (123 aa)
K08C9.7Uncharacterized protein. (154 aa)
M04C3.1SNF2_N domain-containing protein. (1162 aa)
M04C3.2SNF2_N domain-containing protein. (587 aa)
rfp-1E3 ubiquitin-protein ligase bre-1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Belongs to the BRE1 family. (837 aa)
prx-14Pex14_N domain-containing protein. (258 aa)
T05A12.4Uncharacterized protein. (1622 aa)
his-4Histone H2B 2. (123 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
Y104H12D.2Uncharacterized protein. (327 aa)
Y104H12D.4Uncharacterized protein. (107 aa)
Y40B1A.2WW domain-containing protein. (120 aa)
Y43F8B.14SNF2_N domain-containing protein. (593 aa)
ubc-13Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
ZK1098.1WW domain-containing protein ZK1098.1. (724 aa)
his-11Histone H2B 1. (122 aa)
his-15Histone H2B 1. (122 aa)
prx-2RING-type domain-containing protein. (273 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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