STRINGSTRING
trpp-11 trpp-11 aex-3 aex-3 akt-1 akt-1 trpp-9 trpp-9 rab-1 rab-1 trpp-12 trpp-12 rin-1 rin-1 lst-6 lst-6 C56C10.7 C56C10.7 rab-8 rab-8 rab-39 rab-39 trpp-1 trpp-1 rbg-1 rbg-1 rab-5 rab-5 akt-2 akt-2 trpp-4 trpp-4 F39H12.2 F39H12.2 sand-1 sand-1 F41H10.4 F41H10.4 trpp-8 trpp-8 rme-4 rme-4 rme-6 rme-6 denn-4 denn-4 F53H1.3 F53H1.3 F54C9.11 F54C9.11 ccz-1 ccz-1 rab-6.1 rab-6.1 mtm-5 mtm-5 trpp-6 trpp-6 rab-14 rab-14 R06F6.8 R06F6.8 rab-21 rab-21 T10F2.5 T10F2.5 coa-4 coa-4 rbg-2 rbg-2 jph-1 jph-1 rab-10 rab-10 rab-6.2 rab-6.2 rab-7 rab-7 sedl-1 sedl-1 zfp-3 zfp-3 Y39A1A.24 Y39A1A.24 rab-35 rab-35 gdi-1 gdi-1 unc-51 unc-51 rep-1 rep-1 aex-6 aex-6 rab-18 rab-18 trpp-3 trpp-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpp-11Foie-gras_1 domain-containing protein. (1090 aa)
aex-3MAP kinase-activating death domain protein; Plays a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. Is also a regulator of the cab-1 synaptic transmission pathway. Probably by converting rab-3 to its GTP-bound active form, plays a role [...] (1409 aa)
akt-1Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] (546 aa)
trpp-9TRansport Protein Particle. (1240 aa)
rab-1RAB family. (205 aa)
trpp-12TRansport Protein Particle. (380 aa)
rin-1VPS9 domain-containing protein. (1890 aa)
lst-6Lateral Signaling Target. (1487 aa)
C56C10.7Probable trafficking protein particle complex subunit 13 homolog. (401 aa)
rab-8RAB family. (211 aa)
rab-39RAB family. (229 aa)
trpp-1Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (142 aa)
rbg-1Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (915 aa)
rab-5RAB family. (208 aa)
akt-2Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] (528 aa)
trpp-4Trafficking protein particle complex subunit. (224 aa)
F39H12.2WD_REPEATS_REGION domain-containing protein. (347 aa)
sand-1SAND endocytosis protein family. (459 aa)
F41H10.4Uncharacterized protein. (575 aa)
trpp-8TRansport Protein Particle. (1282 aa)
rme-4UDENN domain-containing protein. (661 aa)
rme-6Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits. (1093 aa)
denn-4DENN domain type RAB GEF. (1548 aa)
F53H1.3UDENN domain-containing protein. (554 aa)
F54C9.11Uncharacterized protein. (367 aa)
ccz-1Uncharacterized protein. (528 aa)
rab-6.1Ras-related protein Rab-6.1; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
mtm-5Myotubularin-related protein 5; Probably acts as an adapter for other myotubularin-like phosphatases (Probable); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (1744 aa)
trpp-6TRansport Protein Particle. (185 aa)
rab-14RAB family. (210 aa)
R06F6.8Guanine nucleotide exchange factor subunit R06F6.8; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi; Belongs to the RIC1 family. (1470 aa)
rab-21RAB family. (207 aa)
T10F2.5Uncharacterized protein. (137 aa)
coa-4Cytochrome Oxidase Assembly subunits. (293 aa)
rbg-2Rab3 GTPase-activating protein regulatory subunit; Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase- activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity). (1307 aa)
jph-1JunctoPHilin. (747 aa)
rab-10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa)
rab-6.2Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity). (205 aa)
rab-7RAB family. (209 aa)
sedl-1Probable trafficking protein particle complex subunit 2; May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response; Belongs to the TRAPP small subunits family. Sedlin subfamily. (141 aa)
zfp-3C3H1-type domain-containing protein. (666 aa)
Y39A1A.24Uncharacterized protein. (126 aa)
rab-35RAB family. (209 aa)
gdi-1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (459 aa)
unc-51Serine/threonine-protein kinase unc-51; Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation. Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells. Plays a role in mitophagy during limited food availability. Regulates cell [...] (856 aa)
rep-1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (510 aa)
aex-6Rab27. (215 aa)
rab-18Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells. (203 aa)
trpp-3Trafficking protein particle complex subunit 3 homolog; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Required for the systemic spread of the RNAi response ; Belongs to the TRAPP small subunits family. BET3 subfamily. (181 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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