STRINGSTRING
rpn-10 rpn-10 pbs-6 pbs-6 pas-1 pas-1 rpn-2 rpn-2 C29F9.5 C29F9.5 C29F9.6 C29F9.6 rpn-3 rpn-3 C34F6.10 C34F6.10 psmd-9 psmd-9 pbs-2 pbs-2 C49F5.5 C49F5.5 rpt-1 rpt-1 pas-6 pas-6 pas-2 pas-2 rpn-5 rpn-5 F22F1.3 F22F1.3 rpt-4 rpt-4 rpt-3 rpt-3 ubq-1 ubq-1 daf-3 daf-3 pas-5 pas-5 srh-255 srh-255 egl-44 egl-44 rpt-2 rpt-2 srh-266 srh-266 F34H10.1 F34H10.1 F35G12.12 F35G12.12 pbs-7 pbs-7 cbp-3 cbp-3 rpn-7 rpn-7 F52C6.2 F52C6.2 F52C6.3 F52C6.3 bro-1 bro-1 F56F11.4 F56F11.4 rpt-5 rpt-5 rpn-6.1 rpn-6.1 rpn-6.2 rpn-6.2 ubl-1 ubl-1 cbp-2 cbp-2 pbs-5 pbs-5 rpn-11 rpn-11 lag-1 lag-1 K08C9.7 K08C9.7 pbs-1 pbs-1 cbp-1 cbp-1 sma-4 sma-4 rpn-8 rpn-8 rpn-9 rpn-9 srh-257 srh-257 srh-258 srh-258 srh-264 srh-264 srh-265 srh-265 pbs-4 pbs-4 rpn-1 rpn-1 skp-1 skp-1 pop-1 pop-1 pas-3 pas-3 pbs-3 pbs-3 pcaf-1 pcaf-1 rpt-6 rpt-6 lin-22 lin-22 Y66D12A.9 Y66D12A.9 zfh-2 zfh-2 ubq-2 ubq-2 ZK1010.10 ZK1010.10 rpn-12 rpn-12 pas-7 pas-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpn-1026S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex de [...] (346 aa)
pbs-6Proteasome subunit beta type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (258 aa)
pas-1Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (246 aa)
rpn-226S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa)
C29F9.5Uncharacterized protein. (261 aa)
C29F9.6TAZ-type domain-containing protein. (240 aa)
rpn-326S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (504 aa)
C34F6.10Uncharacterized protein. (1465 aa)
psmd-9Probable 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC); Belongs to the proteasome subunit p27 family. (197 aa)
pbs-2Proteasome subunit beta; Belongs to the peptidase T1B family. (277 aa)
C49F5.5TAZ-type domain-containing protein. (151 aa)
rpt-126S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (435 aa)
pas-6Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (260 aa)
pas-2Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (231 aa)
rpn-5PCI domain-containing protein. (490 aa)
F22F1.3Uncharacterized protein. (245 aa)
rpt-4Probable 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (406 aa)
rpt-3Probable 26S proteasome regulatory subunit 6B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (414 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
daf-3Dwarfin sma. (895 aa)
pas-5Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (248 aa)
srh-255Serpentine Receptor, class H. (329 aa)
egl-44Transcription enhancer factor-like protein egl-44; Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. May be involved in thermal stress response downstream of yap-1. (493 aa)
rpt-2Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1. (443 aa)
srh-266Serpentine Receptor, class H. (327 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
F35G12.12Uncharacterized protein. (491 aa)
pbs-7Proteasome subunit beta; Belongs to the peptidase T1B family. (236 aa)
cbp-3TAZ-type domain-containing protein. (199 aa)
rpn-726S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (410 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
bro-1BROther (Drosophila tx factor partner) homolog. (152 aa)
F56F11.4AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa)
rpt-526S protease regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA [...] (430 aa)
rpn-6.1Probable 26S proteasome regulatory subunit rpn-6.1; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan. (438 aa)
rpn-6.2Probable 26S proteasome regulatory subunit rpn-6.2; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity). (416 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
cbp-2CBP/p300 homolog. (322 aa)
pbs-5Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...] (284 aa)
rpn-1126S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). (312 aa)
lag-1Lin-12 And Glp-1 phenotype. (790 aa)
K08C9.7Uncharacterized protein. (154 aa)
pbs-1Proteasome subunit beta. (242 aa)
cbp-1Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa)
sma-4Dwarfin sma-4; Involved in TGF-beta pathway; Belongs to the dwarfin/SMAD family. (565 aa)
rpn-8MPN domain-containing protein. (362 aa)
rpn-9PCI domain-containing protein. (387 aa)
srh-257Serpentine Receptor, class H. (329 aa)
srh-258Serpentine Receptor, class H. (334 aa)
srh-264Serpentine Receptor, class H. (333 aa)
srh-265Serpentine Receptor, class H. (334 aa)
pbs-4Proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (202 aa)
rpn-126S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (981 aa)
skp-1Uncharacterized protein T27F2.1. (535 aa)
pop-1Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. (438 aa)
pas-3Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (250 aa)
pbs-3Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (204 aa)
pcaf-1P300/CBP Associated Factor homolog. (767 aa)
rpt-626S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases assoc [...] (416 aa)
lin-22BHLH domain-containing protein. (173 aa)
Y66D12A.9Uncharacterized protein. (248 aa)
zfh-2Zinc Finger and Homeobox. (1615 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
ZK1010.10TAZ-type domain-containing protein. (194 aa)
rpn-1226S proteasome non-ATPase regulatory subunit 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (250 aa)
pas-7Proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (250 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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