STRINGSTRING
F32D8.13 F32D8.13 nfyc-1 nfyc-1 F25E2.3 F25E2.3 stdh-4 stdh-4 tag-340 tag-340 imb-1 imb-1 ubc-9 ubc-9 F29B9.8 F29B9.8 nhr-8 nhr-8 F35C8.5 F35C8.5 F42F12.3 F42F12.3 F49E12.10 F49E12.10 drd-1 drd-1 strl-1 strl-1 F52H2.6 F52H2.6 dhs-5 dhs-5 uev-2 uev-2 ran-1 ran-1 K02D3.2 K02D3.2 idi-1 idi-1 dhs-28 dhs-28 R05H5.5 R05H5.5 fdps-1 fdps-1 T07C4.3 T07C4.3 nfya-1 nfya-1 T08H10.1 T08H10.1 T13C5.6 T13C5.6 nfyb-1 nfyb-1 Y38H6C.16 Y38H6C.16 rimb-1 rimb-1 Y39G8B.1 Y39G8B.1 Y39G8B.2 Y39G8B.2 mvk-1 mvk-1 obr-1 obr-1 sbp-1 sbp-1 Y48B6A.13 Y48B6A.13 nfya-2 nfya-2 Y56A3A.2 Y56A3A.2 daf-22 daf-22 Y62E10A.6 Y62E10A.6 hsd-1 hsd-1 Y73F8A.27 Y73F8A.27 Y7A5A.1 Y7A5A.1 Y87G2A.2 Y87G2A.2 ZC116.3 ZC116.3 ZC443.1 ZC443.1 hsd-3 hsd-3 hsd-2 hsd-2 ZK1251.3 ZK1251.3 cyp-44A1 cyp-44A1 nhr-48 nhr-48 ZK84.2 ZK84.2 nlt-1 nlt-1 ZK892.4 ZK892.4 agmo-1 agmo-1 dhcr-7 dhcr-7 B0024.13 B0024.13 dhs-27 dhs-27 stdh-1 stdh-1 stdh-3 stdh-3 C07D8.5 C07D8.5 C07D8.6 C07D8.6 C17C3.1 C17C3.1 C17C3.3 C17C3.3 dhs-6 dhs-6 C24A3.4 C24A3.4 C32D5.12 C32D5.12 C37H5.13 C37H5.13 C41G7.9 C41G7.9 let-767 let-767 C56G3.2 C56G3.2 scp-1 scp-1 D2021.4 D2021.4 maoc-1 maoc-1 hmgr-1 hmgr-1 stdh-2 stdh-2 obr-2 obr-2 F19H6.4 F19H6.4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F32D8.13Uncharacterized protein. (194 aa)
nfyc-1CBFD_NFYB_HMF domain-containing protein. (232 aa)
F25E2.3Uncharacterized protein. (327 aa)
stdh-4Putative steroid dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (317 aa)
tag-340Uncharacterized protein. (447 aa)
imb-1Importin N-terminal domain-containing protein. (896 aa)
ubc-9SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
F29B9.8Uncharacterized protein. (381 aa)
nhr-8Nuclear hormone receptor family member nhr-8; Orphan nuclear receptor. (560 aa)
F35C8.5Cholesterol 25-hydroxylase-like protein; Probable sterol desaturase. (300 aa)
F42F12.33-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (243 aa)
F49E12.10Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (286 aa)
drd-1Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (269 aa)
strl-1Steroidogenic acute regulatory-like protein 1. (259 aa)
F52H2.6Diminuto-like protein; Belongs to the DIMINUTO family. (525 aa)
dhs-5Uncharacterized oxidoreductase dhs-5. (378 aa)
uev-2UBIQUITIN_CONJUGAT_2 domain-containing protein. (230 aa)
ran-1GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. (215 aa)
K02D3.2START domain-containing protein. (236 aa)
idi-1Nudix hydrolase domain-containing protein. (236 aa)
dhs-28SCP2 domain-containing protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (436 aa)
R05H5.5ARV1 homolog. (236 aa)
fdps-1Farnesyl DiPhosphate Synthetase; Belongs to the FPP/GGPP synthase family. (352 aa)
T07C4.3Uncharacterized protein. (649 aa)
nfya-1Nuclear transcription Factor Y, A (Alpha) subunit. (482 aa)
T08H10.1Aldo_ket_red domain-containing protein. (333 aa)
T13C5.6AcidPPc domain-containing protein. (186 aa)
nfyb-1CBFD_NFYB_HMF domain-containing protein. (403 aa)
Y38H6C.16Uncharacterized protein. (190 aa)
rimb-1RIM Binding protein. (1276 aa)
Y39G8B.1Aldo_ket_red domain-containing protein. (316 aa)
Y39G8B.2Aldo_ket_red domain-containing protein. (339 aa)
mvk-1MeValonate Kinase. (614 aa)
obr-1Oxysterol-binding protein; Belongs to the OSBP family. (842 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
Y48B6A.13Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (377 aa)
nfya-2Nuclear transcription Factor Y, A (Alpha) subunit. (281 aa)
Y56A3A.2Peptidase_M50 domain-containing protein. (616 aa)
daf-22Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
Y62E10A.6NADPH:adrenodoxin oxidoreductase, mitochondrial. (458 aa)
hsd-13Beta_HSD domain-containing protein. (462 aa)
Y73F8A.272Fe-2S ferredoxin-type domain-containing protein. (169 aa)
Y7A5A.1FAD-binding PCMH-type domain-containing protein. (538 aa)
Y87G2A.2Uncharacterized protein. (293 aa)
ZC116.3Cubilin homolog; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. (4047 aa)
ZC443.1Aldo_ket_red domain-containing protein. (320 aa)
hsd-33Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (359 aa)
hsd-23Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (374 aa)
ZK1251.33-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (253 aa)
cyp-44A1Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (489 aa)
nhr-48Nuclear hormone receptor family member nhr-48; Orphan nuclear receptor. (817 aa)
ZK84.2Uncharacterized protein. (196 aa)
nlt-1Non-specific lipid-transfer protein-like 1. (118 aa)
ZK892.4CaiB/baiF CoA-transferase family protein ZK892.4; Belongs to the CoA-transferase III family. (340 aa)
agmo-1Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids; Belongs to the sterol desaturase family. TMEM195 subfamily. (505 aa)
dhcr-7DeHydroCholesterol Reductase. (457 aa)
B0024.13Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). (309 aa)
dhs-27Uncharacterized oxidoreductase dhs-27. (320 aa)
stdh-1Putative steroid dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (314 aa)
stdh-3Putative steroid dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa)
C07D8.5Aldo_ket_red domain-containing protein. (134 aa)
C07D8.6Aldo_ket_red domain-containing protein. (317 aa)
C17C3.1Uncharacterized protein. (357 aa)
C17C3.3Uncharacterized protein. (316 aa)
dhs-6SCP2 domain-containing protein. (418 aa)
C24A3.4Uncharacterized protein. (343 aa)
C32D5.123Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (357 aa)
C37H5.13Uncharacterized protein. (414 aa)
C41G7.9Uncharacterized protein. (212 aa)
let-767Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (337 aa)
C56G3.2Aldo_ket_red domain-containing protein. (131 aa)
scp-1SREBP Cleavage activating Protein (SCAP) homolog. (1087 aa)
D2021.4Uncharacterized protein. (294 aa)
maoc-1MAO-C-like dehydratase domain. (298 aa)
hmgr-13-hydroxy-3-methylglutaryl coenzyme A reductase. (550 aa)
stdh-2Putative steroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. (315 aa)
obr-2Oxysterol-binding protein; Belongs to the OSBP family. (436 aa)
F19H6.43-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (243 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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