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| | ztf-4 | RRM domain-containing protein. (367 aa) |
| | cct-7 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (535 aa) |
| | nuo-2 | Complex1_30kDa domain-containing protein; Belongs to the complex I 30 kDa subunit family. (268 aa) |
| | snb-1 | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa) |
| | cav-1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa) |
| | ect-2 | ECT2 (Mammalian Rho GEF) homolog. (932 aa) |
| | cct-2 | T-complex protein 1 subunit beta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin; Belongs to the TCP-1 chaperonin family. (529 aa) |
| | jph-1 | JunctoPHilin. (747 aa) |
| | T23B12.6 | BTB domain-containing protein. (670 aa) |
| | T23E1.1 | Uncharacterized protein. (603 aa) |
| | rlbp-1 | Rho-GAP domain-containing protein. (461 aa) |
| | T23G5.3 | Uncharacterized protein T23G5.3. (262 aa) |
| | sos-1 | Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...] (1493 aa) |
| | lem-2 | LEM protein 2; Essential protein involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with emr-1. May play a role in radiation-induced DNA damage repair response. (500 aa) |
| | rga-1 | Rho-GAP domain-containing protein. (444 aa) |
| | W02B8.2 | Uncharacterized protein. (1256 aa) |
| | rab-7 | RAB family. (209 aa) |
| | lap-2 | Putative aminopeptidase W07G4.4. (522 aa) |
| | Y105E8A.25 | DH domain-containing protein. (1619 aa) |
| | cul-3 | Cullin-3; Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule st [...] (777 aa) |
| | aap-1 | Phosphoinositide 3-kinase adapter subunit. (522 aa) |
| | Y110A7A.9 | WD_REPEATS_REGION domain-containing protein. (1019 aa) |
| | itsn-1 | ITSN (Intersectin) family. (1087 aa) |
| | Y17G7B.23 | Uncharacterized protein. (265 aa) |
| | hgap-1 | Rap-GAP domain-containing protein. (1306 aa) |
| | Y22D7AL.10 | Uncharacterized protein; Belongs to the GroES chaperonin family. (108 aa) |
| | Y22D7AL.9 | TPR_REGION domain-containing protein. (836 aa) |
| | crp-1 | Cdc-42 Related Protein. (187 aa) |
| | Y34B4A.4 | Uncharacterized protein. (877 aa) |
| | rga-8 | Rho-GAP domain-containing protein. (709 aa) |
| | gei-18 | GEX Interacting protein. (304 aa) |
| | max-2 | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] (649 aa) |
| | Y41E3.1 | Uncharacterized protein. (682 aa) |
| | ani-3 | Anillin-like protein 3. (709 aa) |
| | dnj-27 | DNaJ domain (Prokaryotic heat shock protein). (788 aa) |
| | efhd-1 | EF HanD calcium binding protein. (687 aa) |
| | ddl-2 | WASH_WAHD domain-containing protein. (497 aa) |
| | frl-1 | FRL (Formin Related gene in Leukocytes) homolog. (1115 aa) |
| | ani-1 | Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...] (1159 aa) |
| | grdn-1 | Girdin homolog; Scaffolding protein that plays a role in ciliogenesis, cilium positioning and dendrite anchoring in sensory amphid neurons including AWB, AWA, AWC, ADL and ASI and the phasmid neurons PHA and PHB. Its role in cilium positioning may be through regulation of the localization of cell adhesion proteins such as the apical junction protein ajm-1, and the ciliary scaffolding protein Rootletin/che-10. Belongs to the CCDC88 family. (1319 aa) |
| | rho-1 | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa) |
| | rga-2 | Rho GTPase Activating protein. (908 aa) |
| | Y53F4B.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (463 aa) |
| | txl-1 | Thioredoxin-like protein TXL. (284 aa) |
| | Y54E5B.2 | WD_REPEATS_REGION domain-containing protein. (861 aa) |
| | Y54G2A.18 | 4D656. (213 aa) |
| | magu-1 | MAGUK family. (567 aa) |
| | csn-4 | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mi [...] (412 aa) |
| | rbm-39 | RNA Binding Motif protein homolog. (580 aa) |
| | Y55F3AR.2 | Thioredoxin domain-containing protein. (254 aa) |
| | lem-4 | Ankyrin repeat and LEM domain-containing protein 2 homolog; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of baf-1 during mitotic exit. Coordinates the control of baf-1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of baf-1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. (603 aa) |
| | vha-19 | Vacuolar H ATPase. (451 aa) |
| | Y57G11C.1147 | Uncharacterized protein. (74 aa) |
| | csn-1 | COP9 signalosome complex subunit 1; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the mei [...] (601 aa) |
| | emc-3 | ER membrane protein complex subunit 3. (234 aa) |
| | hum-8 | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1279 aa) |
| | Y67A10A.7 | Arm_2 domain-containing protein. (345 aa) |
| | Y67D8C.22 | Uncharacterized protein. (225 aa) |
| | Y6B3B.3 | WSN domain-containing protein. (1107 aa) |
| | Y73B6BL.12 | Thioredoxin; Belongs to the thioredoxin family. (136 aa) |
| | Y73F8A.35 | Uncharacterized protein. (654 aa) |
| | rga-4 | Rho-GAP domain-containing protein. (1135 aa) |
| | Y81G3A.4 | Uncharacterized protein. (264 aa) |
| | ubxn-2 | UBX domain-containing protein 2; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling [...] (301 aa) |
| | ZC13.1 | RING-type domain-containing protein. (398 aa) |
| | sdz-35 | BTB domain-containing protein. (225 aa) |
| | ZC239.13 | BTB domain-containing protein. (84 aa) |
| | ZC239.14 | BTB domain-containing protein. (223 aa) |
| | ZC239.15 | BTB domain-containing protein. (232 aa) |
| | ZC239.16 | BTB domain-containing protein. (155 aa) |
| | ZC239.17 | BTB_2 domain-containing protein. (132 aa) |
| | ZC239.2 | BTB_2 domain-containing protein. (208 aa) |
| | ZC239.3 | BTB domain-containing protein. (139 aa) |
| | ZC239.4 | BTB domain-containing protein. (231 aa) |
| | ZC239.5 | BTB domain-containing protein. (204 aa) |
| | ZC239.6 | BTB domain-containing protein. (258 aa) |
| | ZC449.1 | Uncharacterized protein. (454 aa) |
| | ufbp-1 | DDRGK domain-containing protein 1. (324 aa) |
| | nck-1 | NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. (395 aa) |
| | clc-3 | CLaudin-like in Caenorhabditis. (222 aa) |
| | sorf-1 | Suppressor of organelle fusion 1; Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR91 family. (239 aa) |
| | spv-1 | Spermathecal Physiology Variant. (966 aa) |
| | dbt-1 | 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxyl [...] (448 aa) |
| | ZK849.1 | PDZ domain-containing protein. (331 aa) |
| | gopc-1 | PDZ domain-containing protein. (414 aa) |
| | cyk-4 | CYtoKinesis defect. (681 aa) |
| | mrck-1 | Serine/threonine-protein kinase mrck-1; Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation. Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation. (1592 aa) |
| | ephx-1 | EPHeXin (Eph-interacting GEF) homolog. (1159 aa) |
| | ile-1 | L-type lectin-like domain-containing protein. (492 aa) |
| | cdc-48.3 | ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into she [...] (724 aa) |
| | rac-2 | Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation. (195 aa) |
| | K03A11.4 | Uncharacterized protein. (664 aa) |
| | K02F6.8 | BTB domain-containing protein. (232 aa) |
| | K02F6.6 | Uncharacterized protein. (112 aa) |
| | K02F6.5 | BTB domain-containing protein. (232 aa) |
| | K02E7.4 | Uncharacterized protein. (113 aa) |
| | K02D10.1 | Putative NipSnap protein K02D10.1. (526 aa) |
| | H40L08.1 | Uncharacterized protein. (444 aa) |
| | syp-4 | Synaptonemal complex protein 4; Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC. Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination. (605 aa) |
| | rga-5 | Rho-GAP domain-containing protein. (1341 aa) |
| | frm-3 | FERM domain-containing protein. (1091 aa) |
| | cdh-9 | CaDHerin family. (623 aa) |
| | F59A6.5 | Uncharacterized protein. (1286 aa) |
| | cri-3 | Conserved regulator of innate immunity protein 3; Belongs to the MAM33 family. (236 aa) |
| | letm-1 | LETM1 (Leucine zipper, EF-hand, TransMembrane mitochondrial protein) homolog. (784 aa) |
| | exc-6 | Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis. (843 aa) |
| | daam-1 | FH2 domain-containing protein. (987 aa) |
| | hum-7 | Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1880 aa) |
| | gex-2 | Cytoplasmic FMR1-interacting protein homolog; Required for initial steps of body morphogenesis. May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (1262 aa) |
| | unc-73 | Guanine nucleotide exchange factor UNC-73A. (2488 aa) |
| | F55C12.5 | SMP-LTD domain-containing protein. (925 aa) |
| | syx-5 | Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family. (413 aa) |
| | rog-1 | IRS-type PTB domain-containing protein. (599 aa) |
| | nud-1 | CS domain-containing protein. (320 aa) |
| | sorf-2 | Suppressor of organelle fusion 2; Together with sorf-1 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-1 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR81 family. (1422 aa) |
| | ubxn-3 | UBX domain-containing protein 3; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. (613 aa) |
| | spe-15 | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1219 aa) |
| | rrc-1 | GTPase-activating protein rrc-1; Functions as a GTPase-activating protein (GAP) for ced- 10/rac-1 and CDC42. (759 aa) |
| | rhi-1 | Probable rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (191 aa) |
| | F46H5.4 | Uncharacterized protein; Belongs to the DOCK family. (2018 aa) |
| | pkn-1 | Protein Kinase N (PKN) homolog. (1138 aa) |
| | gei-1 | START domain-containing protein. (1510 aa) |
| | sly-1 | SLY1 homolog; Belongs to the STXBP/unc-18/SEC1 family. (675 aa) |
| | tbc-18 | TBC (Tre-2/Bub2/Cdc16) domain family. (826 aa) |
| | mtx-1 | Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family. (312 aa) |
| | twf-2 | TWinFilin actin binding protein homolog. (333 aa) |
| | srh-241 | Serpentine Receptor, class H. (335 aa) |
| | srh-243 | Serpentine Receptor, class H. (337 aa) |
| | srh-186 | Serpentine Receptor, class H. (329 aa) |
| | rbpl-1 | Retinoblastoma Binding Protein Like. (1128 aa) |
| | syd-1 | Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1. (987 aa) |
| | F33H2.2 | Uncharacterized protein. (816 aa) |
| | D2045.8 | BTB domain-containing protein. (238 aa) |
| | nrd-1 | NRD (Yeast Nuclear pre-mRNA Down-regulation) homolog. (988 aa) |
| | cav-2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family. (351 aa) |
| | C52B9.4 | Uncharacterized protein. (558 aa) |
| | C50C3.2 | Uncharacterized protein C50C3.2; Belongs to the spectrin family. (2236 aa) |
| | C49H3.6 | CortBP2 domain-containing protein. (552 aa) |
| | unc-112 | Protein unc-112; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable regulator of cell-extracellular matrix adhesion. Required during initial muscle assembly to form dense bodies and M-lines. (720 aa) |
| | hsp-90 | Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa) |
| | pak-2 | Serine/threonine-protein kinase pak-2; Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration. (522 aa) |
| | C44H4.4 | Chorein_N domain-containing protein. (996 aa) |
| | pmp-2 | Peroxisomal Membrane Protein related. (661 aa) |
| | pmp-1 | Peroxisomal Membrane Protein related. (665 aa) |
| | perm-4 | PERMeable eggshell. (331 aa) |
| | cdc-48.2 | Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] (810 aa) |
| | C40A11.7 | BTB domain-containing protein. (220 aa) |
| | C40A11.6 | BTB domain-containing protein. (218 aa) |
| | C40A11.4 | BTB domain-containing protein. (228 aa) |
| | C40A11.3 | BTB domain-containing protein. (231 aa) |
| | C40A11.2 | BTB domain-containing protein. (213 aa) |
| | tag-325 | WW domain-containing protein tag-325. (840 aa) |
| | C37A2.8 | Uncharacterized protein. (336 aa) |
| | swah-1 | ANK_REP_REGION domain-containing protein. (298 aa) |
| | mig-2 | Rac-like GTPase. (195 aa) |
| | vav-1 | Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis. (1007 aa) |
| | stam-1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa) |
| | gop-3 | SAM50-like protein gop-3; May play a role in the maintenance of the structure of mitochondrial cristae; Belongs to the SAM50/omp85 family. (434 aa) |
| | exc-5 | Uncharacterized protein. (861 aa) |
| | C33A12.1 | Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (150 aa) |
| | ubc-23 | UAS domain-containing protein. (395 aa) |
| | C24A1.3 | Uncharacterized protein. (850 aa) |
| | rsp-8 | RRM domain-containing protein. (309 aa) |
| | C18D11.3 | Uncharacterized protein. (175 aa) |
| | C17F4.8 | BTB domain-containing protein. (207 aa) |
| | sem-5 | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] (228 aa) |
| | cgef-1 | DH domain-containing protein. (1055 aa) |
| | tiam-1 | DH domain-containing protein. (889 aa) |
| | let-502 | Rho-associated protein kinase let-502; Negatively regulates mel-11 to relieve the inhibition of mlc- 4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization. (1173 aa) |
| | ced-10 | Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa) |
| | C09D4.4 | DUF676 domain-containing protein. (916 aa) |
| | pak-1 | Serine/threonine-protein kinase pak-1; Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip ce [...] (572 aa) |
| | hgrs-1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. (729 aa) |
| | wsp-1 | WASP (Actin cytoskeleton modulator) homolog. (781 aa) |
| | C07B5.4 | PH domain-containing protein. (515 aa) |
| | C07A9.5 | Uncharacterized calcium-binding protein C07A9.5. (358 aa) |
| | cdc-48.1 | Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa) |
| | pld-1 | Phospholipase. (1427 aa) |
| | pac-1 | GTPase-activating protein pac-1; GTPase-activating protein for members of the Rho subfamily including Rac1, RhoA and cdc42 and other Ras-related subfamilies including let-60. Mediates radial (inner-outer) polarity and gastrulation by excluding par-6 from contacted cell surfaces; acts by inactivating cdc42 at inner cell surfaces which limits active cdc42 to outer cell surfaces devoid of cell-cell contacts, where cdc42 can bind and recruit par-6. Required for blastomere polarization. (1718 aa) |
| | gck-4 | Protein kinase domain-containing protein. (1228 aa) |
| | srh-244 | Serpentine Receptor, class H. (336 aa) |
| | ced-5 | CED-5. (1781 aa) |
| | tag-52 | Putative protein tag-52. (665 aa) |
| | rga-6 | Rho-GAP domain-containing protein. (986 aa) |
| | magu-2 | MAGUK family; Belongs to the MAGUK family. (830 aa) |
| | chin-1 | CHImaeriN (Rac-GTPase-activating protein) homolog. (421 aa) |
| | vang-1 | Vang-like protein. (532 aa) |
| | ykt-6 | YKT6 (Yeast v-SNARE) homolog; Belongs to the synaptobrevin family. (201 aa) |
| | abi-1 | SH3 domain-containing protein. (469 aa) |
| | hpo-28 | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. (567 aa) |
| | B0281.6 | BTB domain-containing protein. (212 aa) |
| | B0281.5 | BTB domain-containing protein. (207 aa) |
| | B0281.4 | Uncharacterized protein. (147 aa) |
| | viro-2 | WH1 domain-containing protein. (616 aa) |
| | csn-2 | COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the mei [...] (495 aa) |
| | rga-9 | Rho-GAP domain-containing protein. (478 aa) |
| | golg-2 | GOLGi associated coiled-coil protein homolog. (928 aa) |
| | F32G8.2 | Uncharacterized protein. (561 aa) |
| | uig-1 | PH domain-containing protein. (972 aa) |
| | F32D8.2 | Uncharacterized protein. (568 aa) |
| | srh-245 | Serpentine Receptor, class H. (330 aa) |
| | grld-1 | Glutamate Receptor Level Decreased. (520 aa) |
| | rsr-1 | PWI domain-containing protein. (601 aa) |
| | gex-3 | Membrane-associated protein gex-3; Rac effector required for tissue morphogenesis, cell migrations and egg laying. May play a role in egg laying and in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. (1141 aa) |
| | F23H11.4 | Rho-GAP domain-containing protein. (1003 aa) |
| | F22G12.5 | DHR-2 domain-containing protein; Belongs to the DOCK family. (2338 aa) |
| | F22G12.4 | Uncharacterized protein. (1107 aa) |
| | F22E5.8 | BTB domain-containing protein. (276 aa) |
| | F22E5.6 | BTB domain-containing protein. (225 aa) |
| | F22E5.13 | Uncharacterized protein. (98 aa) |
| | F22E5.12 | BTB domain-containing protein. (139 aa) |
| | F22E5.11 | BTB domain-containing protein. (317 aa) |
| | chw-1 | CHp/Wrch Rho-like protein homolog. (207 aa) |
| | F21C10.6 | CX domain-containing protein. (189 aa) |
| | F18A11.5 | BTB domain-containing protein. (231 aa) |
| | F15H10.7 | Uncharacterized protein. (666 aa) |
| | inft-2 | FH2 domain-containing protein. (1120 aa) |
| | git-1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. (670 aa) |
| | rhgf-1 | RHo Guanine nucleotide exchange Factor. (1340 aa) |
| | F13D12.3 | Uncharacterized protein. (245 aa) |
| | srgp-1 | Rho-GAP domain-containing protein. (1059 aa) |
| | cyk-1 | CYtoKinesis defect. (1437 aa) |
| | F10C2.3 | Uncharacterized protein. (604 aa) |
| | pes-7 | Patterned Expression Site. (1391 aa) |
| | F07F6.4 | Uncharacterized protein F07F6.4; GTPase-activating protein for the ADP ribosylation factor family. (529 aa) |
| | flp-6 | FMRFamide-like neuropeptides 6; FMRFamides and FMRFamide-like peptides are neuropeptides. KSAYMRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (170 aa) |
| | F07C3.3 | Uncharacterized protein. (746 aa) |
| | din-1 | Daf-12-interacting protein 1; [Isoform d]: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause. (2407 aa) |
| | F02E9.1 | Uncharacterized protein. (154 aa) |
| | hlh-16 | BHLH domain-containing protein. (146 aa) |
| | maco-1 | Macoilin; Plays a role in the regulation of neuronal activity. (897 aa) |
| | lap-1 | Leucine aminopeptidase 1; Probably acts as a digestive enzyme. (491 aa) |
| | rga-3 | Rho-GAP domain-containing protein. (1085 aa) |
| | ani-2 | Anillin-like protein 2; Required to maintain the structure of the rachis, the central cytoplasmic core of the syncytial adult gonad. Failure to maintain the rachis leads to premature dissociation of oocytes and thereby impedes oogenesis. (1009 aa) |
| | spc-1 | SPeCtrin. (2432 aa) |
| | mlk-1 | Mitogen-activated protein kinase kinase kinase mlk-1; Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Involved in the response to environmental stress such as heavy metals. By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury. (1059 aa) |
| | pix-1 | PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. (646 aa) |
| | M03F8.5 | Uncharacterized protein. (417 aa) |
| | M04B2.2 | THUMP domain-containing protein. (391 aa) |
| | cap-2 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (270 aa) |
| | R02F11.4 | Uncharacterized protein. (630 aa) |
| | osg-1 | Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. (1182 aa) |
| | metr-1 | Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1249 aa) |
| | R03G8.1 | Uncharacterized protein. (663 aa) |
| | R03G8.3 | Uncharacterized protein. (654 aa) |
| | wve-1 | WH2 domain-containing protein. (468 aa) |
| | cdc-42 | Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa) |
| | sti-1 | Stress-induced-phosphoprotein 1; Plays a role in gonad development. Up-regulates longevity and thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity. (320 aa) |
| | msi-1 | Neural RNA-binding protein MSI-1. (320 aa) |
| | sax-1 | Serine/threonine-protein kinase sax-1; Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (476 aa) |
| | wip-1 | WH2 domain-containing protein. (362 aa) |
| | dnj-16 | J domain-containing protein. (395 aa) |
| | ubxn-5 | UBX domain-containing protein 5; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. Unlike other UBX domain- containing protein does not bind 'Lys-48'-polyubiquitinated chain. (174 aa) |
| | T04C9.1 | Uncharacterized protein. (881 aa) |
| | T05E12.3 | BTB domain-containing protein. (261 aa) |
| | T07G12.3 | Uncharacterized protein. (623 aa) |
| | T08G3.13 | BTB domain-containing protein. (177 aa) |
| | T09B4.2 | Uncharacterized protein. (309 aa) |
