(32 nodes) CDC42 GTPase cycle network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gei-1	START domain-containing protein. (1510 aa)
	uig-1	PH domain-containing protein. (972 aa)
	F23H11.4	Rho-GAP domain-containing protein. (1003 aa)
	F22G12.5	DHR-2 domain-containing protein; Belongs to the DOCK family. (2338 aa)
	F21C10.6	CX domain-containing protein. (189 aa)
	srgp-1	Rho-GAP domain-containing protein. (1059 aa)
	cav-2	Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family. (351 aa)
	exc-5	Uncharacterized protein. (861 aa)
	ykt-6	YKT6 (Yeast v-SNARE) homolog; Belongs to the synaptobrevin family. (201 aa)
	spv-1	Spermathecal Physiology Variant. (966 aa)
	sorf-1	Suppressor of organelle fusion 1; Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR91 family. (239 aa)
	clc-3	CLaudin-like in Caenorhabditis. (222 aa)
	rga-2	Rho GTPase Activating protein. (908 aa)
	ddl-2	WASH_WAHD domain-containing protein. (497 aa)
	itsn-1	ITSN (Intersectin) family. (1087 aa)
	rab-7	RAB family. (209 aa)
	rga-1	Rho-GAP domain-containing protein. (444 aa)
	rlbp-1	Rho-GAP domain-containing protein. (461 aa)
	T23B12.6	BTB domain-containing protein. (670 aa)
	ect-2	ECT2 (Mammalian Rho GEF) homolog. (932 aa)
	cav-1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. (235 aa)
	rga-9	Rho-GAP domain-containing protein. (478 aa)
	T04C9.1	Uncharacterized protein. (881 aa)
	wip-1	WH2 domain-containing protein. (362 aa)
	cyk-4	CYtoKinesis defect. (681 aa)
	ephx-1	EPHeXin (Eph-interacting GEF) homolog. (1159 aa)
	syp-4	Synaptonemal complex protein 4; Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC. Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination. (605 aa)
	rga-5	Rho-GAP domain-containing protein. (1341 aa)
	sorf-2	Suppressor of organelle fusion 2; Together with sorf-1 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-1 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR81 family. (1422 aa)
	rrc-1	GTPase-activating protein rrc-1; Functions as a GTPase-activating protein (GAP) for ced- 10/rac-1 and CDC42. (759 aa)
	rhi-1	Probable rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (191 aa)
	F46H5.4	Uncharacterized protein; Belongs to the DOCK family. (2018 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F22G12.5	F46H5.4	F22G12.5c.1	F46H5.4.1	DHR-2 domain-containing protein; Belongs to the DOCK family.	Uncharacterized protein; Belongs to the DOCK family.	0.466
F22G12.5	ephx-1	F22G12.5c.1	K07D4.7a.1	DHR-2 domain-containing protein; Belongs to the DOCK family.	EPHeXin (Eph-interacting GEF) homolog.	0.726
F22G12.5	exc-5	F22G12.5c.1	C33D9.1c.1	DHR-2 domain-containing protein; Belongs to the DOCK family.	Uncharacterized protein.	0.581
F22G12.5	uig-1	F22G12.5c.1	F32F2.1b.1	DHR-2 domain-containing protein; Belongs to the DOCK family.	PH domain-containing protein.	0.531
F23H11.4	T04C9.1	F23H11.4a.1	T04C9.1a.1	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.538
F23H11.4	cyk-4	F23H11.4a.1	K08E3.6.2	Rho-GAP domain-containing protein.	CYtoKinesis defect.	0.455
F23H11.4	gei-1	F23H11.4a.1	F45H7.2a.1	Rho-GAP domain-containing protein.	START domain-containing protein.	0.406
F23H11.4	rga-1	F23H11.4a.1	W02B12.8a.1	Rho-GAP domain-containing protein.	Rho-GAP domain-containing protein.	0.413
F23H11.4	rga-2	F23H11.4a.1	Y53C10A.4.1	Rho-GAP domain-containing protein.	Rho GTPase Activating protein.	0.457
F23H11.4	rga-5	F23H11.4a.1	H08M01.2b.1	Rho-GAP domain-containing protein.	Rho-GAP domain-containing protein.	0.420
F23H11.4	rga-9	F23H11.4a.1	2RSSE.1b.1	Rho-GAP domain-containing protein.	Rho-GAP domain-containing protein.	0.457
F23H11.4	rlbp-1	F23H11.4a.1	T23G11.5a.1	Rho-GAP domain-containing protein.	Rho-GAP domain-containing protein.	0.403
F23H11.4	spv-1	F23H11.4a.1	ZK669.1a.1	Rho-GAP domain-containing protein.	Spermathecal Physiology Variant.	0.420
F23H11.4	srgp-1	F23H11.4a.1	F12F6.5a.1	Rho-GAP domain-containing protein.	Rho-GAP domain-containing protein.	0.406
F46H5.4	F22G12.5	F46H5.4.1	F22G12.5c.1	Uncharacterized protein; Belongs to the DOCK family.	DHR-2 domain-containing protein; Belongs to the DOCK family.	0.466
F46H5.4	ect-2	F46H5.4.1	T19E10.1b.1	Uncharacterized protein; Belongs to the DOCK family.	ECT2 (Mammalian Rho GEF) homolog.	0.478
F46H5.4	ephx-1	F46H5.4.1	K07D4.7a.1	Uncharacterized protein; Belongs to the DOCK family.	EPHeXin (Eph-interacting GEF) homolog.	0.427
F46H5.4	exc-5	F46H5.4.1	C33D9.1c.1	Uncharacterized protein; Belongs to the DOCK family.	Uncharacterized protein.	0.726
F46H5.4	uig-1	F46H5.4.1	F32F2.1b.1	Uncharacterized protein; Belongs to the DOCK family.	PH domain-containing protein.	0.676
T04C9.1	F23H11.4	T04C9.1a.1	F23H11.4a.1	Uncharacterized protein.	Rho-GAP domain-containing protein.	0.538