node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C50C3.2 | sem-5 | C50C3.2.1 | C14F5.5.1 | Uncharacterized protein C50C3.2; Belongs to the spectrin family. | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] | 0.400 |
C50C3.2 | spc-1 | C50C3.2.1 | K10B3.10b.1 | Uncharacterized protein C50C3.2; Belongs to the spectrin family. | SPeCtrin. | 0.800 |
git-1 | hgrs-1 | F14F3.2.1 | C07G1.5.2 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | 0.418 |
git-1 | hum-8 | F14F3.2.1 | Y66H1A.6c.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.400 |
git-1 | itsn-1 | F14F3.2.1 | Y116A8C.36d.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | ITSN (Intersectin) family. | 0.433 |
git-1 | max-2 | F14F3.2.1 | Y38F1A.10e.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] | 0.950 |
git-1 | nck-1 | F14F3.2.1 | ZK470.5a.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. | 0.571 |
git-1 | pak-1 | F14F3.2.1 | C09B8.7a.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Serine/threonine-protein kinase pak-1; Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip ce [...] | 0.950 |
git-1 | pix-1 | F14F3.2.1 | K11E4.4a.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. | 0.992 |
git-1 | sem-5 | F14F3.2.1 | C14F5.5.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] | 0.487 |
git-1 | spc-1 | F14F3.2.1 | K10B3.10b.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | SPeCtrin. | 0.516 |
git-1 | stam-1 | F14F3.2.1 | C34G6.7a.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | 0.413 |
git-1 | txl-1 | F14F3.2.1 | Y54E10A.3.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Thioredoxin-like protein TXL. | 0.400 |
hgrs-1 | git-1 | C07G1.5.2 | F14F3.2.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | 0.418 |
hgrs-1 | hum-8 | C07G1.5.2 | Y66H1A.6c.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.400 |
hgrs-1 | itsn-1 | C07G1.5.2 | Y116A8C.36d.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | ITSN (Intersectin) family. | 0.563 |
hgrs-1 | max-2 | C07G1.5.2 | Y38F1A.10e.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] | 0.436 |
hgrs-1 | nck-1 | C07G1.5.2 | ZK470.5a.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family. | 0.401 |
hgrs-1 | pak-1 | C07G1.5.2 | C09B8.7a.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Serine/threonine-protein kinase pak-1; Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip ce [...] | 0.438 |
hgrs-1 | pix-1 | C07G1.5.2 | K11E4.4a.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | PIX (PAK (p21-activated kinase) Interacting eXchange factor) homolog. | 0.406 |