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his-38 his-38 cbp-2 cbp-2 his-18 his-18 his-22 his-22 his-28 his-28 his-20 his-20 pqn-51 pqn-51 htz-1 htz-1 cbp-1 cbp-1 srh-257 srh-257 srh-258 srh-258 srh-264 srh-264 srh-265 srh-265 rpb-10 rpb-10 gtf-2A2 gtf-2A2 Y104H12D.4 Y104H12D.4 Y104H12D.2 Y104H12D.2 rpb-11 rpb-11 his-67 his-67 vab-19 vab-19 tbp-1 tbp-1 his-1 his-1 his-4 his-4 lsd-1 lsd-1 his-52 his-52 his-50 his-50 his-44 his-44 his-31 his-31 his-34 his-34 his-64 his-64 F22F1.3 F22F1.3 rpb-12 rpb-12 rpb-8 rpb-8 srh-255 srh-255 srh-266 srh-266 his-29 his-29 ama-1 ama-1 tlf-1 tlf-1 cbp-3 cbp-3 rpb-4 rpb-4 his-8 his-8 his-39 his-39 his-5 his-5 F52B5.2 F52B5.2 his-56 his-56 his-58 his-58 his-60 his-60 his-62 his-62 bro-1 bro-1 end-3 end-3 his-66 his-66 cdk-9 cdk-9 rpb-5 rpb-5 H39E23.3 H39E23.3 elt-3 elt-3 his-48 his-48 his-46 his-46 B0336.13 B0336.13 gtf-2F1 gtf-2F1 rpb-6 rpb-6 elt-7 elt-7 rpb-2 rpb-2 C29F9.5 C29F9.5 C29F9.6 C29F9.6 rpb-3 rpb-3 hsp-90 hsp-90 C49F5.5 C49F5.5 his-41 his-41 his-37 his-37 his-54 his-54 ZK154.4 ZK154.4 his-15 his-15 his-14 his-14 his-11 his-11 his-10 his-10 his-26 his-26 ZK1010.10 ZK1010.10 daf-41 daf-41 rpb-9 rpb-9 Y73B3A.8 Y73B3A.8 rpb-7 rpb-7 spr-5 spr-5 gtf-2F2 gtf-2F2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-38Histone H4. (103 aa)
cbp-2CBP/p300 homolog. (322 aa)
his-18Histone H4. (103 aa)
his-22Histone H2B 2. (123 aa)
his-28Histone H4. (103 aa)
his-20Histone H2B 2. (123 aa)
pqn-51Prion-like-(Q/N-rich)-domain-bearing protein. (354 aa)
htz-1Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal [...] (140 aa)
cbp-1Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa)
srh-257Serpentine Receptor, class H. (329 aa)
srh-258Serpentine Receptor, class H. (334 aa)
srh-264Serpentine Receptor, class H. (333 aa)
srh-265Serpentine Receptor, class H. (334 aa)
rpb-10DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the cor [...] (67 aa)
gtf-2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. (113 aa)
Y104H12D.4Uncharacterized protein. (107 aa)
Y104H12D.2Uncharacterized protein. (327 aa)
rpb-11Probable DNA-directed RNA polymerase II subunit RPB11; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). (122 aa)
his-67Histone H4. (103 aa)
vab-19ANK_REP_REGION domain-containing protein. (1040 aa)
tbp-1TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (340 aa)
his-1Histone H4. (103 aa)
his-4Histone H2B 2. (123 aa)
lsd-1Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (737 aa)
his-52Histone H2B 2. (123 aa)
his-50Histone H4. (103 aa)
his-44Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (122 aa)
his-31Histone H4. (103 aa)
his-34Histone H2B 1. (122 aa)
his-64Histone H4. (103 aa)
F22F1.3Uncharacterized protein. (245 aa)
rpb-12RNA Polymerase II (B) subunit. (62 aa)
rpb-8Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity); Belongs to the eukaryotic RPB8 RNA polymerase subunit family. (148 aa)
srh-255Serpentine Receptor, class H. (329 aa)
srh-266Serpentine Receptor, class H. (327 aa)
his-29Histone H2B 1. (122 aa)
ama-1DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
tlf-1TBP-Like Factor. (508 aa)
cbp-3TAZ-type domain-containing protein. (199 aa)
rpb-4RPOL4c domain-containing protein. (144 aa)
his-8Histone H2B 2. (123 aa)
his-39Histone domain-containing protein; Belongs to the histone H2B family. (67 aa)
his-5Histone H4. (103 aa)
F52B5.2Protein kinase domain-containing protein. (301 aa)
his-56Histone H4. (103 aa)
his-58Probable histone H2B 4. (123 aa)
his-60Histone H4. (103 aa)
his-62Probable histone H2B 4. (123 aa)
bro-1BROther (Drosophila tx factor partner) homolog. (152 aa)
end-3GATA-type domain-containing protein. (242 aa)
his-66Probable histone H2B 4. (123 aa)
cdk-9Probable cyclin-dependent kinase 9; Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5. (478 aa)
rpb-5DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (211 aa)
H39E23.3Uncharacterized protein. (746 aa)
elt-3GATA-type domain-containing protein. (317 aa)
his-48Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
B0336.13Transcription initiation factor IIA small chain homolog. (139 aa)
gtf-2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (481 aa)
rpb-6Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of t [...] (137 aa)
elt-7Transcription factor elt-7; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Required for gut- specific differentiation, specifically acting with the GATA region- binding transcription factor elt-2 to control normal gene expression and promote normal formation of the intestine. May have a protective role in response to infection by Gram-negative bacteria such as P.aeruginosa. (198 aa)
rpb-2DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] (1194 aa)
C29F9.5Uncharacterized protein. (261 aa)
C29F9.6TAZ-type domain-containing protein. (240 aa)
rpb-3RPOLD domain-containing protein. (282 aa)
hsp-90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa)
C49F5.5TAZ-type domain-containing protein. (151 aa)
his-41Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
his-37Histone H4. (103 aa)
his-54Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (123 aa)
ZK154.4Uncharacterized protein. (203 aa)
his-15Histone H2B 1. (122 aa)
his-14Histone H4. (103 aa)
his-11Histone H2B 1. (122 aa)
his-10Histone H4. (103 aa)
his-26Histone H4. (103 aa)
ZK1010.10TAZ-type domain-containing protein. (194 aa)
daf-41Co-chaperone protein daf-41; Co-chaperone for hsp90/daf-21. Involved in regulation of longevity, larval entry and exit from the dauer stage of development and response to environmental cues, such as oxidative stress, in a temperature-dependent manner. Role in daf-16 and hsf-1 inhibition at elevated temperatures. Belongs to the p23/wos2 family. (175 aa)
rpb-9TFIIS-type domain-containing protein; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (167 aa)
Y73B3A.8annotation not available (60 aa)
rpb-7S1 motif domain-containing protein. (197 aa)
spr-5Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] (770 aa)
gtf-2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (263 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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