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madf-11 | MADF domain-containing protein. (516 aa) | ||||
skr-17 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa) | ||||
usp-14 | Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily. (489 aa) | ||||
kxd-1 | KxDL domain-containing protein. (140 aa) | ||||
rpn-2 | 26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa) | ||||
rege-1 | Endoribonuclease rege-1; Endonuclease which binds to the 3'UTR of target mRNAs and induces degradation of the transcript. Negatively regulates the expression of the transcription factor ets-4, which probably controls the expression of lipid metabolism genes. May play a role in the clearance of apoptotic cell corpses. (634 aa) | ||||
pas-4 | Proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (253 aa) | ||||
skr-16 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa) | ||||
tap-1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. (386 aa) | ||||
pbs-2 | Proteasome subunit beta; Belongs to the peptidase T1B family. (277 aa) | ||||
skr-12 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) | ||||
skr-9 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) | ||||
skr-13 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa) | ||||
skr-8 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) | ||||
pas-6 | Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (260 aa) | ||||
cul-1 | Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa) | ||||
peli-1 | PELI1 and PELI2 related. (458 aa) | ||||
ubq-1 | Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa) | ||||
tli-1 | ToLlIp homolog. (243 aa) | ||||
mltn-1 | MLt-TeN (Mlt-10) related. (709 aa) | ||||
F34H10.1 | Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa) | ||||
skr-3 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa) | ||||
skr-2 | SKp1 Related (Ubiquitin ligase complex component). (174 aa) | ||||
skr-1 | Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa) | ||||
skr-5 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa) | ||||
kbrl-1 | NF-kappa-B inhibitor-interacting Ras-like protein; Atypical Ras-like protein that may act as a regulator of NF- kappa-B activity. (364 aa) | ||||
F52C6.2 | Ubiquitin-like domain-containing protein. (228 aa) | ||||
F52C6.3 | Ubiquitin-like domain-containing protein. (197 aa) | ||||
mom-4 | Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (536 aa) | ||||
skr-15 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa) | ||||
skr-18 | Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa) | ||||
rpt-5 | 26S protease regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA [...] (430 aa) | ||||
ubl-1 | Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa) | ||||
pbs-5 | Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...] (284 aa) | ||||
K08C9.7 | Uncharacterized protein. (154 aa) | ||||
cul-6 | Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa) | ||||
skr-21 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (176 aa) | ||||
pik-1 | Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. (485 aa) | ||||
lin-23 | F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity). (667 aa) | ||||
rpn-8 | MPN domain-containing protein. (362 aa) | ||||
skr-19 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa) | ||||
skr-20 | SKp1 Related (Ubiquitin ligase complex component). (173 aa) | ||||
zak-1 | SAM domain-containing protein. (745 aa) | ||||
sqst-3 | ZZ-type domain-containing protein. (229 aa) | ||||
mltn-3 | MLt-TeN (Mlt-10) related. (743 aa) | ||||
mltn-5 | MLt-TeN (Mlt-10) related. (738 aa) | ||||
Y105C5A.24 | Protein kinase domain-containing protein. (478 aa) | ||||
skr-10 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa) | ||||
Y106G6A.1 | Protein kinase domain-containing protein. (430 aa) | ||||
dsbn-1 | Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the dysbindin family. (210 aa) | ||||
sqst-4 | ZZ-type domain-containing protein. (177 aa) | ||||
skr-6 | SKp1 Related (Ubiquitin ligase complex component). (106 aa) | ||||
skr-7 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa) | ||||
skr-14 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa) | ||||
Y53C10A.5 | TMEM189_B_dmain domain-containing protein. (319 aa) | ||||
ubc-13 | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa) | ||||
skr-4 | SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa) | ||||
ubq-2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa) | ||||
rbx-1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa) |