STRINGSTRING
vps-4 vps-4 vps-25 vps-25 vps-24 vps-24 T24B8.2 T24B8.2 mam-4 mam-4 R12C12.5 R12C12.5 K08C9.7 K08C9.7 mvb-12 mvb-12 C01A2.4 C01A2.4 stam-1 stam-1 vps-22 vps-22 ubl-1 ubl-1 kxd-1 kxd-1 tsg-101 tsg-101 hgrs-1 hgrs-1 F52C6.2 F52C6.2 vps-60 vps-60 F34H10.1 F34H10.1 ubq-1 ubq-1 vps-36 vps-36 F52C6.3 F52C6.3 vps-37 vps-37 CD4.11 CD4.11 vps-32.1 vps-32.1 ubq-2 ubq-2 vps-28 vps-28 vps-20 vps-20 vps-2 vps-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vps-4Related to yeast Vacuolar Protein Sorting factor; Belongs to the AAA ATPase family. (430 aa)
vps-25Related to yeast Vacuolar Protein Sorting factor. (183 aa)
vps-24Related to yeast Vacuolar Protein Sorting factor. (208 aa)
T24B8.2Charged Multivesicular Body Protein homolog. (411 aa)
mam-4MAM (Meprin, A5-protein, PTPmu) domain protein. (588 aa)
R12C12.5Uncharacterized protein. (236 aa)
K08C9.7Uncharacterized protein. (154 aa)
mvb-12MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa)
C01A2.4Uncharacterized protein. (207 aa)
stam-1Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa)
vps-22Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (269 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
kxd-1KxDL domain-containing protein. (140 aa)
tsg-101Tumor Susceptibility Gene homolog. (425 aa)
hgrs-1Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. (729 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
vps-60Related to yeast Vacuolar Protein Sorting factor. (217 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
vps-36GLUE N-terminal domain-containing protein. (383 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
vps-37VPS37 C-terminal domain-containing protein. (234 aa)
CD4.11Uncharacterized protein. (496 aa)
vps-32.1Related to yeast Vacuolar Protein Sorting factor. (221 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
vps-28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa)
vps-20Related to yeast Vacuolar Protein Sorting factor. (208 aa)
vps-2Related to yeast Vacuolar Protein Sorting factor. (237 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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