STRINGSTRING
skr-1 skr-1 madf-11 madf-11 skr-17 skr-17 skr-16 skr-16 skr-12 skr-12 skr-9 skr-9 skr-13 skr-13 skr-8 skr-8 cul-1 cul-1 ubq-1 ubq-1 F34H10.1 F34H10.1 skr-3 skr-3 rbx-1 rbx-1 skr-4 skr-4 skr-14 skr-14 skr-7 skr-7 skr-6 skr-6 skr-10 skr-10 skr-20 skr-20 skr-19 skr-19 skr-21 skr-21 cul-6 cul-6 K08C9.7 K08C9.7 ubl-1 ubl-1 skr-18 skr-18 skr-15 skr-15 F52C6.3 F52C6.3 F52C6.2 F52C6.2 skpt-1 skpt-1 skr-5 skr-5 skr-2 skr-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
skr-1Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa)
madf-11MADF domain-containing protein. (516 aa)
skr-17SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa)
skr-16SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa)
skr-12SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
skr-9SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-13SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
skr-8SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
cul-1Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
skr-3SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa)
rbx-1RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa)
skr-4SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa)
skr-14SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa)
skr-7SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-6SKp1 Related (Ubiquitin ligase complex component). (106 aa)
skr-10SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa)
skr-20SKp1 Related (Ubiquitin ligase complex component). (173 aa)
skr-19Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa)
skr-21Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (176 aa)
cul-6Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa)
K08C9.7Uncharacterized protein. (154 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
skr-18Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa)
skr-15SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
skpt-1F-box domain-containing protein. (421 aa)
skr-5SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa)
skr-2SKp1 Related (Ubiquitin ligase complex component). (174 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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