STRINGSTRING
unc-3 unc-3 F49E10.2 F49E10.2 ptr-24 ptr-24 otpl-7 otpl-7 otpl-6 otpl-6 otpl-5 otpl-5 otpl-4 otpl-4 ptr-8 ptr-8 F43D9.1 F43D9.1 ifo-1 ifo-1 agr-1 agr-1 F40F4.7 F40F4.7 F38C2.4 F38C2.4 F37C4.6 F37C4.6 tax-2 tax-2 F36A2.9 F36A2.9 dhs-20 dhs-20 F32B4.4 F32B4.4 daf-6 daf-6 srsx-40 srsx-40 ZC443.1 ZC443.1 unc-52 unc-52 ptr-22 ptr-22 ptr-21 ptr-21 Y65B4BR.1 Y65B4BR.1 eps-8 eps-8 Y55F3AM.11 Y55F3AM.11 ptr-20 ptr-20 Y48E1C.1 Y48E1C.1 bcmo-1 bcmo-1 Y46E12A.3 Y46E12A.3 Y44F5A.1 Y44F5A.1 Y40H7A.4 Y40H7A.4 Y40B10A.9 Y40B10A.9 Y39G8B.7 Y39G8B.7 Y39F10A.3 Y39F10A.3 ptr-19 ptr-19 ptr-18 ptr-18 nape-1 nape-1 F31D4.5 F31D4.5 nape-2 nape-2 map-1 map-1 Y37A1A.4 Y37A1A.4 ptr-17 ptr-17 F53B6.5 F53B6.5 map-2 map-2 W02B12.1 W02B12.1 T27A8.3 T27A8.3 srsx-36 srsx-36 srsx-38 srsx-38 ptr-16 ptr-16 T19D7.7 T19D7.7 srsx-33 srsx-33 nmt-1 nmt-1 tmc-1 tmc-1 ptr-15 ptr-15 ptr-14 ptr-14 R07B7.9 R07B7.9 R07B7.8 R07B7.8 R05A10.8 R05A10.8 srsx-39 srsx-39 srsx-37 srsx-37 vit-1 vit-1 let-99 let-99 vit-6 vit-6 ptr-13 ptr-13 ptr-12 ptr-12 K06H6.2 K06H6.2 ptr-23 ptr-23 ZK643.6 ZK643.6 ZK792.4 ZK792.4 ZK856.5 ZK856.5 calm-1 calm-1 F28A10.5 F28A10.5 exl-1 exl-1 lhfp-4 lhfp-4 pef-1 pef-1 srsx-32 srsx-32 otpl-3 otpl-3 F13H8.11 F13H8.11 F09C8.1 F09C8.1 cdh-5 cdh-5 F01D5.5 F01D5.5 F01D5.3 F01D5.3 F01D5.2 F01D5.2 F01D5.1 F01D5.1 otpl-2 otpl-2 ptr-6 ptr-6 ptr-5 ptr-5 srsx-29 srsx-29 srsx-28 srsx-28 srsx-27 srsx-27 srsx-26 srsx-26 sop-2 sop-2 ptr-4 ptr-4 vit-2 vit-2 ptr-3 ptr-3 ptr-2 ptr-2 ptr-1 ptr-1 dhs-16 dhs-16 vit-5 vit-5 tmc-2 tmc-2 otpl-1 otpl-1 otpl-8 otpl-8 vit-4 vit-4 vit-3 vit-3 gpn-1 gpn-1 sdn-1 sdn-1 ptr-11 ptr-11 ptr-10 ptr-10 drd-5 drd-5 dhs-2 dhs-2 ptr-9 ptr-9 F54E7.9 F54E7.9 srsx-35 srsx-35 bcmo-2 bcmo-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
unc-3Transcription factor unc-3; May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development. (491 aa)
F49E10.2Uncharacterized protein. (842 aa)
ptr-24SSD domain-containing protein. (892 aa)
otpl-7OToPetrin-Like. (627 aa)
otpl-6OToPetrin-Like. (581 aa)
otpl-5OToPetrin-Like. (572 aa)
otpl-4OToPetrin-Like. (558 aa)
ptr-8SSD domain-containing protein. (890 aa)
F43D9.1SSD domain-containing protein. (1226 aa)
ifo-1Intermediate Filament Organize. (1292 aa)
agr-1AGRin (Synaptic protein) homolog family member. (1473 aa)
F40F4.7N-acetyltransferase domain-containing protein. (245 aa)
F38C2.4Methyltransf_21 domain-containing protein. (275 aa)
F37C4.6Amino_oxidase domain-containing protein. (544 aa)
tax-2Cyclic nucleotide-binding domain-containing protein. (800 aa)
F36A2.9Lipase_GDSL domain-containing protein. (565 aa)
dhs-20DeHydrogenases, Short chain. (342 aa)
F32B4.4Pharyngeal muscle protein 2; Involved in pharyngeal muscle development and ensures pharyngeal grinder function during feeding. Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine. Has a role in the determination of life span. (1073 aa)
daf-6SSD domain-containing protein. (913 aa)
srsx-40Serpentine Receptor, class SX. (186 aa)
ZC443.1Aldo_ket_red domain-containing protein. (320 aa)
unc-52Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa)
ptr-22SSD domain-containing protein. (888 aa)
ptr-21SSD domain-containing protein. (909 aa)
Y65B4BR.1Lipase_GDSL domain-containing protein. (377 aa)
eps-8SH3 domain-containing protein. (942 aa)
Y55F3AM.11Methyltranfer_dom domain-containing protein. (323 aa)
ptr-20SSD domain-containing protein. (860 aa)
Y48E1C.1Uncharacterized protein. (447 aa)
bcmo-1Beta-Carotene 15,15'-MonoOxygenase. (529 aa)
Y46E12A.3Glutaredoxin domain-containing protein. (235 aa)
Y44F5A.1WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family. (383 aa)
Y40H7A.4Methyltransf_21 domain-containing protein. (291 aa)
Y40B10A.9Uncharacterized protein. (433 aa)
Y39G8B.7Uncharacterized protein. (179 aa)
Y39F10A.3Methyltransf_21 domain-containing protein. (309 aa)
ptr-19SSD domain-containing protein. (1003 aa)
ptr-18SSD domain-containing protein. (895 aa)
nape-1Lactamase_B domain-containing protein. (356 aa)
F31D4.5Pleckstrin homology domain-containing family D member 1. (570 aa)
nape-2Lactamase_B domain-containing protein. (376 aa)
map-1Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (371 aa)
Y37A1A.4PL48 domain-containing protein. (1071 aa)
ptr-17SSD domain-containing protein. (936 aa)
F53B6.5Uncharacterized protein. (182 aa)
map-2Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for germ cell proliferation and/or differentiation. (468 aa)
W02B12.1Lipase_GDSL domain-containing protein. (382 aa)
T27A8.3Putative uncharacterized protein T27A8.3; Belongs to the peptidase M24 family. (182 aa)
srsx-36G_PROTEIN_RECEP_F1_2 domain-containing protein. (302 aa)
srsx-38G_PROTEIN_RECEP_F1_2 domain-containing protein. (308 aa)
ptr-16SSD domain-containing protein. (898 aa)
T19D7.7Lipase_GDSL domain-containing protein. (471 aa)
srsx-33G_PROTEIN_RECEP_F1_2 domain-containing protein. (303 aa)
nmt-1Probable glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. (452 aa)
tmc-1Transmembrane channel-like protein 1; Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl. Belongs to the TMC family. (1285 aa)
ptr-15SSD domain-containing protein. (840 aa)
ptr-14SSD domain-containing protein. (877 aa)
R07B7.9Lipase_GDSL domain-containing protein. (484 aa)
R07B7.8Lipase_GDSL domain-containing protein. (436 aa)
R05A10.8Methyltransf_21 domain-containing protein. (280 aa)
srsx-39G_PROTEIN_RECEP_F1_2 domain-containing protein. (311 aa)
srsx-37G_PROTEIN_RECEP_F1_2 domain-containing protein. (302 aa)
vit-1Vitellogenin-1; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1616 aa)
let-99Protein let-99; Required for the proper orientation of spindles after the establishment of polarity. May play a role in interactions between the astral microtubules and the cortical cytoskeleton. Required for asymmetric forces on nuclei and spindles. Acts downstream of the PAR signaling as an intermediate that transduces polarity information to the machinery that positions the mitotic spindle, possibly by regulating force generation. Regulates gpr-1/2 asymmetric cortical localization during the first embryonic cell divisions. Acts antagonistically to the gpr-1/2 signaling pathway. Regu [...] (698 aa)
vit-6Vitellogenin-6; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance. (1651 aa)
ptr-13SSD domain-containing protein. (851 aa)
ptr-12SSD domain-containing protein. (901 aa)
K06H6.2Methyltransf_21 domain-containing protein. (288 aa)
ptr-23SSD domain-containing protein. (983 aa)
ZK643.6Uncharacterized protein ZK643.6. (244 aa)
ZK792.4ANK_REP_REGION domain-containing protein. (510 aa)
ZK856.5Metallophos domain-containing protein. (459 aa)
calm-1CALMyrin (Calcium and Integrin Binding protein) homolog. (201 aa)
F28A10.5Methyltransf_21 domain-containing protein. (293 aa)
exl-1Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family. (238 aa)
lhfp-4Lipoma Hmgic (HMGIC) Fusion Partner-like homolog. (229 aa)
pef-1Serine/threonine-protein phosphatase with EF-hands pef-1; Probably acts as a protein phosphatase. (707 aa)
srsx-32G_PROTEIN_RECEP_F1_2 domain-containing protein. (302 aa)
otpl-3OToPetrin-Like. (566 aa)
F13H8.11Lipase_GDSL domain-containing protein. (460 aa)
F09C8.1Lipase_GDSL domain-containing protein. (374 aa)
cdh-5CaDHerin family. (1449 aa)
F01D5.5Uncharacterized protein. (165 aa)
F01D5.3Uncharacterized protein. (132 aa)
F01D5.2Uncharacterized protein. (133 aa)
F01D5.1Uncharacterized protein. (178 aa)
otpl-2OToPetrin-Like. (576 aa)
ptr-6SSD domain-containing protein. (982 aa)
ptr-5SSD domain-containing protein. (961 aa)
srsx-29G_PROTEIN_RECEP_F1_2 domain-containing protein. (315 aa)
srsx-28G_PROTEIN_RECEP_F1_2 domain-containing protein. (322 aa)
srsx-27G_PROTEIN_RECEP_F1_2 domain-containing protein. (327 aa)
srsx-26G_PROTEIN_RECEP_F1_2 domain-containing protein. (215 aa)
sop-2Polycomb protein sop-2; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes and for localization of sor-1. Binds RNA. (737 aa)
ptr-4SSD domain-containing protein. (960 aa)
vit-2Vitellogenin-2; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1613 aa)
ptr-3SSD domain-containing protein. (927 aa)
ptr-2SSD domain-containing protein. (933 aa)
ptr-1SSD domain-containing protein. (956 aa)
dhs-163 beta-hydroxysteroid dehydrogenase dhs-16; 3 beta-hydroxysteroid dehydrogenase that converts 3 beta- hydroxysteroids to 3-ketosteroids, an essential step in the production of Delta(7)-dafachronic acid from cholesterol. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. Required for longevity in the absence of the germline. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa)
vit-5Vitellogenin-5; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1603 aa)
tmc-2Transmembrane channel-like protein 2; Probable ion channel; Belongs to the TMC family. (1238 aa)
otpl-1OToPetrin-Like. (752 aa)
otpl-8OToPetrin-Like. (619 aa)
vit-4Vitellogenin-4; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1603 aa)
vit-3Vitellogenin-3; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1603 aa)
gpn-1GlyPicaN; Belongs to the glypican family. (543 aa)
sdn-1Probable syndecan; Cell surface proteoglycan that bears heparan sulfate (By similarity). Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2. Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts. Promotes the axon guidance of D-type motor neurons. (288 aa)
ptr-11SSD domain-containing protein. (820 aa)
ptr-10SSD domain-containing protein. (900 aa)
drd-5Dietary restriction down regulated. (331 aa)
dhs-2DeHydrogenases, Short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (368 aa)
ptr-9Patched-related protein 9; Belongs to the patched family. (844 aa)
F54E7.9N-acetyltransferase domain-containing protein. (167 aa)
srsx-35G_PROTEIN_RECEP_F1_2 domain-containing protein. (313 aa)
bcmo-2Beta-Carotene 15,15'-MonoOxygenase. (530 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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