STRINGSTRING
trx-2 trx-2 rpn-10 rpn-10 trx-1 trx-1 ooc-3 ooc-3 B0353.1 B0353.1 lin-66 lin-66 sco-1 sco-1 pbs-6 pbs-6 C04B4.1 C04B4.1 C04B4.2 C04B4.2 C04B4.4 C04B4.4 C04E12.4 C04E12.4 C04E12.5 C04E12.5 C04E6.11 C04E6.11 madf-11 madf-11 cdc-48.1 cdc-48.1 skr-17 skr-17 trxr-1 trxr-1 sod-3 sod-3 C10G11.8 C10G11.8 gpx-5 gpx-5 gpx-3 gpx-3 akt-1 akt-1 kxd-1 kxd-1 gei-8 gei-8 C14C10.5 C14C10.5 sod-1 sod-1 pas-1 pas-1 C17B7.5 C17B7.5 C17D12.3 C17D12.3 rpn-2 rpn-2 C29F9.5 C29F9.5 C29F9.6 C29F9.6 rpn-3 rpn-3 imp-3 imp-3 sgo-1 sgo-1 pas-4 pas-4 cdc-48.2 cdc-48.2 skr-16 skr-16 psmd-9 psmd-9 C44H4.6 C44H4.6 gsr-1 gsr-1 pbs-2 pbs-2 C49F5.5 C49F5.5 skr-12 skr-12 skr-9 skr-9 skr-13 skr-13 skr-8 skr-8 rpt-1 rpt-1 pas-6 pas-6 pas-2 pas-2 cul-1 cul-1 cyc-2.1 cyc-2.1 sin-3 sin-3 dpt-1 dpt-1 prdx-2 prdx-2 sod-2 sod-2 rpn-5 rpn-5 ufd-1 ufd-1 F22F1.3 F22F1.3 rpt-4 rpt-4 rpt-3 rpt-3 ubq-1 ubq-1 pas-5 pas-5 gpx-1 gpx-1 cox-7C cox-7C cox-5B cox-5B srh-255 srh-255 akt-2 akt-2 rpt-2 rpt-2 srh-266 srh-266 F34H10.1 F34H10.1 F35F10.1 F35F10.1 F35G12.12 F35G12.12 F36D4.5 F36D4.5 F37A4.5 F37A4.5 gst-25 gst-25 pbs-7 pbs-7 cbp-3 cbp-3 skr-3 skr-3 skr-2 skr-2 skr-1 skr-1 skr-5 skr-5 skpt-1 skpt-1 rpn-7 rpn-7 F52C6.2 F52C6.2 F52C6.3 F52C6.3 skr-15 skr-15 cox-6A cox-6A gpx-8 gpx-8 sod-4 sod-4 skr-18 skr-18 F56F11.4 F56F11.4 rpt-5 rpt-5 rpn-6.1 rpn-6.1 rpn-6.2 rpn-6.2 sft-1 sft-1 ubl-1 ubl-1 cox-11 cox-11 cbp-2 cbp-2 cdc-48.3 cdc-48.3 pbs-5 pbs-5 rpn-11 rpn-11 K08C9.7 K08C9.7 pbs-1 pbs-1 cul-6 cul-6 skr-21 skr-21 ctc-3 ctc-3 ctc-1 ctc-1 ctc-2 ctc-2 gpx-7 gpx-7 R05H10.3 R05H10.3 gpx-2 gpx-2 prdx-3 prdx-3 gst-1 gst-1 cbp-1 cbp-1 rpn-8 rpn-8 skr-19 skr-19 skr-20 skr-20 T01D3.3 T01D3.3 atf-5 atf-5 imp-2 imp-2 rpn-9 rpn-9 srh-257 srh-257 srh-258 srh-258 srh-264 srh-264 srh-265 srh-265 T08G11.4 T08G11.4 gpx-6 gpx-6 skn-1 skn-1 T20D4.3 T20D4.3 pbs-4 pbs-4 rpn-1 rpn-1 sqst-3 sqst-3 T28B8.3 T28B8.3 T28B8.4 T28B8.4 W01B11.6 W01B11.6 sknr-1 sknr-1 W04G5.4 W04G5.4 W04G5.5 W04G5.5 cox-4 cox-4 skr-10 skr-10 cul-3 cul-3 pas-3 pas-3 Y116F11B.7 Y116F11B.7 gsk-3 gsk-3 sqst-4 sqst-4 cox-5A cox-5A skr-6 skr-6 ndx-4 ndx-4 pbs-3 pbs-3 trx-4 trx-4 skr-7 skr-7 skr-14 skr-14 Y47H9A.1 Y47H9A.1 Y48G8AL.15 Y48G8AL.15 rpt-6 rpt-6 Y50D4B.4 Y50D4B.4 taco-1 taco-1 ctl-3 ctl-3 ctl-2 ctl-2 ctl-1 ctl-1 cox-18 cox-18 skr-4 skr-4 Y66D12A.9 Y66D12A.9 cox-6B cox-6B sesn-1 sesn-1 gpx-4 gpx-4 cyc-2.2 cyc-2.2 ubq-2 ubq-2 ZK1010.10 ZK1010.10 rpn-12 rpn-12 rbx-1 rbx-1 sod-5 sod-5 trxr-2 trxr-2 pas-7 pas-7
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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trx-2Probable thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. (145 aa)
rpn-1026S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex de [...] (346 aa)
trx-1Thioredoxin-1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Shown to facilitate the reduction of insulin disulfide bonds. Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide. Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to [...] (115 aa)
ooc-3Uncharacterized protein. (448 aa)
B0353.1Uncharacterized protein B0353.1. (435 aa)
lin-66Uncharacterized protein. (627 aa)
sco-1SCO (Yeast Suppressor of Cytochrome Oxidase deficiency) homolog. (312 aa)
pbs-6Proteasome subunit beta type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (258 aa)
C04B4.1Uncharacterized protein. (491 aa)
C04B4.2Uncharacterized protein. (474 aa)
C04B4.4Uncharacterized protein. (489 aa)
C04E12.4Uncharacterized protein. (609 aa)
C04E12.5Uncharacterized protein. (484 aa)
C04E6.11Uncharacterized protein. (995 aa)
madf-11MADF domain-containing protein. (516 aa)
cdc-48.1Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...] (809 aa)
skr-17SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (180 aa)
trxr-1Thioredoxin reductase 1; Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting. (667 aa)
sod-3Superoxide dismutase [Mn] 2, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. (218 aa)
C10G11.8AAA domain-containing protein; Belongs to the AAA ATPase family. (438 aa)
gpx-5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
gpx-3Glutathione peroxidase 3; Belongs to the glutathione peroxidase family. (224 aa)
akt-1Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...] (546 aa)
kxd-1KxDL domain-containing protein. (140 aa)
gei-8Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism. (1778 aa)
C14C10.5Uncharacterized protein. (1908 aa)
sod-1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). Required for normal brood size. May be involved in regulating mpk-1 phosphorylation downstream of phosphatase ptp-2 during oocyte maturation. (180 aa)
pas-1Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (246 aa)
C17B7.5Uncharacterized protein. (848 aa)
C17D12.3Uncharacterized protein. (418 aa)
rpn-226S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (965 aa)
C29F9.5Uncharacterized protein. (261 aa)
C29F9.6TAZ-type domain-containing protein. (240 aa)
rpn-326S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (504 aa)
imp-3IntraMembrane Protease (IMPAS) family. (530 aa)
sgo-1Shugoshin; Component of cell cycle checkpoints, which ensures chromosome segregation during meiosis and mitosis. During meiotic prophase, it is involved in the regulation of the synapsis checkpoint, which monitors whether homologous chromosomes have synapsed, and the DNA damage response. Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex after prophase, when most of cohesin complex dissociates from chromosomes arms (By similarity). Belongs to the shugoshin family. (309 aa)
pas-4Proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (253 aa)
cdc-48.2Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents [...] (810 aa)
skr-16SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (181 aa)
psmd-9Probable 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC); Belongs to the proteasome subunit p27 family. (197 aa)
C44H4.6Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (367 aa)
gsr-1Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting. (473 aa)
pbs-2Proteasome subunit beta; Belongs to the peptidase T1B family. (277 aa)
C49F5.5TAZ-type domain-containing protein. (151 aa)
skr-12SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
skr-9SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-13SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (172 aa)
skr-8SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
rpt-126S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (435 aa)
pas-6Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (260 aa)
pas-2Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (231 aa)
cul-1Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa)
cyc-2.1Cytochrome c 2.1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (111 aa)
sin-3Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC). (1507 aa)
dpt-1Dipeptidyl peptidase 3; Belongs to the peptidase M49 family. (745 aa)
prdx-2Thioredoxin domain-containing protein. (201 aa)
sod-2Superoxide dismutase [Mn] 1, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. (221 aa)
rpn-5PCI domain-containing protein. (490 aa)
ufd-1Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway (By similarity). In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradati [...] (342 aa)
F22F1.3Uncharacterized protein. (245 aa)
rpt-4Probable 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (406 aa)
rpt-3Probable 26S proteasome regulatory subunit 6B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (414 aa)
ubq-1Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...] (838 aa)
pas-5Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (248 aa)
gpx-1Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (163 aa)
cox-7CCytochrome OXidase assembly protein. (84 aa)
cox-5BCytochrome OXidase assembly protein. (132 aa)
srh-255Serpentine Receptor, class H. (329 aa)
akt-2Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...] (528 aa)
rpt-2Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1. (443 aa)
srh-266Serpentine Receptor, class H. (327 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
F35F10.1PAW domain-containing protein. (239 aa)
F35G12.12Uncharacterized protein. (491 aa)
F36D4.5Desumoylating isopeptidase 1 homolog; Protease which deconjugates SUMO from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubql-1 in the export of ubiquitinated proteins from the nucleus to the cytoplasm. (334 aa)
F37A4.5Uncharacterized protein F37A4.5; Belongs to the peptidase M67A family. (319 aa)
gst-25Glutathione S-Transferase. (208 aa)
pbs-7Proteasome subunit beta; Belongs to the peptidase T1B family. (236 aa)
cbp-3TAZ-type domain-containing protein. (199 aa)
skr-3SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (167 aa)
skr-2SKp1 Related (Ubiquitin ligase complex component). (174 aa)
skr-1Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination. (176 aa)
skr-5SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (145 aa)
skpt-1F-box domain-containing protein. (421 aa)
rpn-726S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (410 aa)
F52C6.2Ubiquitin-like domain-containing protein. (228 aa)
F52C6.3Ubiquitin-like domain-containing protein. (197 aa)
skr-15SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (184 aa)
cox-6ACytochrome c oxidase subunit 6A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (128 aa)
gpx-8Glutathione PeroXidase. (145 aa)
sod-4Extracellular superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (221 aa)
skr-18Skp1 domain-containing protein; Belongs to the SKP1 family. (183 aa)
F56F11.4AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa)
rpt-526S protease regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA [...] (430 aa)
rpn-6.1Probable 26S proteasome regulatory subunit rpn-6.1; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan. (438 aa)
rpn-6.2Probable 26S proteasome regulatory subunit rpn-6.2; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity). (416 aa)
sft-1SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family. (323 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
cox-11Cytochrome OXidase assembly protein. (260 aa)
cbp-2CBP/p300 homolog. (322 aa)
cdc-48.3ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into she [...] (724 aa)
pbs-5Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...] (284 aa)
rpn-1126S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). (312 aa)
K08C9.7Uncharacterized protein. (154 aa)
pbs-1Proteasome subunit beta. (242 aa)
cul-6Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa)
skr-21Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (176 aa)
ctc-3Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (255 aa)
ctc-1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (525 aa)
ctc-2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (231 aa)
gpx-7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
R05H10.3Uncharacterized protein. (591 aa)
gpx-2Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (179 aa)
prdx-3Probable peroxiredoxin prdx-3; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (226 aa)
gst-1Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). Prevents dopaminergic CEP neuron degeneration in response to Mn(2+). (208 aa)
cbp-1Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1. (2017 aa)
rpn-8MPN domain-containing protein. (362 aa)
skr-19Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (155 aa)
skr-20SKp1 Related (Ubiquitin ligase complex component). (173 aa)
T01D3.3Thyroglobulin type-1 domain-containing protein. (1011 aa)
atf-5BZIP domain-containing protein. (208 aa)
imp-2Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family. (468 aa)
rpn-9PCI domain-containing protein. (387 aa)
srh-257Serpentine Receptor, class H. (329 aa)
srh-258Serpentine Receptor, class H. (334 aa)
srh-264Serpentine Receptor, class H. (333 aa)
srh-265Serpentine Receptor, class H. (334 aa)
T08G11.4Uncharacterized protein. (566 aa)
gpx-6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (188 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
T20D4.3Uncharacterized protein. (687 aa)
pbs-4Proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family. (202 aa)
rpn-126S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (981 aa)
sqst-3ZZ-type domain-containing protein. (229 aa)
T28B8.3DUF3437 domain-containing protein. (1879 aa)
T28B8.4Uncharacterized protein. (1874 aa)
W01B11.6Thioredoxin domain-containing protein. (109 aa)
sknr-1BZIP domain-containing protein. (385 aa)
W04G5.4Uncharacterized protein. (523 aa)
W04G5.5Uncharacterized protein. (412 aa)
cox-4Cytochrome OXidase assembly protein. (175 aa)
skr-10SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (192 aa)
cul-3Cullin-3; Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule st [...] (777 aa)
pas-3Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family. (250 aa)
Y116F11B.7Uncharacterized protein. (418 aa)
gsk-3Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...] (362 aa)
sqst-4ZZ-type domain-containing protein. (177 aa)
cox-5ACytochrome c oxidase subunit 5A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] (174 aa)
skr-6SKp1 Related (Ubiquitin ligase complex component). (106 aa)
ndx-4Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. (138 aa)
pbs-3Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (204 aa)
trx-4Thioredoxin; Belongs to the thioredoxin family. (107 aa)
skr-7SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (194 aa)
skr-14SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (168 aa)
Y47H9A.1annotation not available (418 aa)
Y48G8AL.15NDK domain-containing protein. (139 aa)
rpt-626S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases assoc [...] (416 aa)
Y50D4B.4PAW domain-containing protein Y50D4B.3. (791 aa)
taco-1Translational Activator of Cytochrome c Oxidase. (285 aa)
ctl-3Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (512 aa)
ctl-2Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. (500 aa)
ctl-1Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. (497 aa)
cox-18Cytochrome OXidase assembly protein. (317 aa)
skr-4SKp1 Related (Ubiquitin ligase complex component); Belongs to the SKP1 family. (159 aa)
Y66D12A.9Uncharacterized protein. (248 aa)
cox-6BCytochrome OXidase assembly protein. (121 aa)
sesn-1Sestrin homolog; May function as a negative feedback regulator of TOR function. (474 aa)
gpx-4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (126 aa)
cyc-2.2Probable cytochrome c 2.2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (123 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
ZK1010.10TAZ-type domain-containing protein. (194 aa)
rpn-1226S proteasome non-ATPase regulatory subunit 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (250 aa)
rbx-1RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation. (110 aa)
sod-5Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (178 aa)
trxr-2Probable glutathione reductase 2; Maintains high levels of reduced glutathione in the cytosol. (503 aa)
pas-7Proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (250 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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