STRINGSTRING
osm-9 osm-9 eat-6 eat-6 clec-117 clec-117 clh-2 clh-2 best-1 best-1 best-2 best-2 best-3 best-3 best-4 best-4 catp-4 catp-4 catp-2 catp-2 gtl-1 gtl-1 C06E2.1 C06E2.1 best-5 best-5 clh-5 clh-5 best-6 best-6 C09B9.85 C09B9.85 catp-3 catp-3 catp-8 catp-8 unc-77 unc-77 kxd-1 kxd-1 nkb-1 nkb-1 vha-8 vha-8 del-9 del-9 C18H9.3 C18H9.3 delm-2 delm-2 acd-1 acd-1 acd-2 acd-2 vha-7 vha-7 acd-3 acd-3 nca-2 nca-2 trpa-1 trpa-1 best-7 best-7 vha-16 vha-16 C30G4.4 C30G4.4 best-8 best-8 unc-105 unc-105 nkb-2 nkb-2 best-9 best-9 wnk-1 wnk-1 deg-1 deg-1 best-10 best-10 best-11 best-11 C56G2.5 C56G2.5 del-1 del-1 unc-79 unc-79 clh-3 clh-3 tat-6 tat-6 flr-1 flr-1 sto-1 sto-1 pqn-29 pqn-29 mec-2 mec-2 best-12 best-12 mec-10 mec-10 F17C8.6 F17C8.6 vha-12 vha-12 delm-1 delm-1 unc-80 unc-80 degt-1 degt-1 acd-4 acd-4 ocr-1 ocr-1 sto-2 sto-2 best-13 best-13 best-14 best-14 F33G12.6 F33G12.6 F34H10.1 F34H10.1 vha-5 vha-5 tat-5 tat-5 F37C4.8 F37C4.8 csq-1 csq-1 F41E6.11 F41E6.11 F41E7.1 F41E7.1 F41E7.2 F41E7.2 cup-15 cup-15 ttyh-1 ttyh-1 vha-10 vha-10 clec-79 clec-79 vha-17 vha-17 vha-18 vha-18 gtl-2 gtl-2 nkb-3 nkb-3 egas-4 egas-4 vha-14 vha-14 anoh-1 anoh-1 F57G8.5 F57G8.5 unc-24 unc-24 F58G6.8 F58G6.8 del-5 del-5 tat-2 tat-2 ubl-1 ubl-1 H17B01.2 H17B01.2 spe-41 spe-41 mbl-1 mbl-1 unc-1 unc-1 catp-5 catp-5 K08C9.7 K08C9.7 K09A9.6 K09A9.6 unc-68 unc-68 sca-1 sca-1 unc-43 unc-43 K11H3.8 K11H3.8 mca-2 mca-2 trp-2 trp-2 clh-6 clh-6 clec-175 clec-175 sao-1 sao-1 vha-2 vha-2 vha-1 vha-1 best-15 best-15 unc-8 unc-8 best-16 best-16 cup-5 cup-5 R144.11 R144.11 mec-4 mec-4 vha-4 vha-4 gon-2 gon-2 clh-4 clh-4 ocr-2 ocr-2 ocr-3 ocr-3 T13G4.1 T13G4.1 vha-15 vha-15 T18D3.7 T18D3.7 T19B10.2 T19B10.2 best-17 best-17 best-18 best-18 best-19 best-19 tat-4 tat-4 clh-1 clh-1 del-4 del-4 del-10 del-10 acd-5 acd-5 asic-2 asic-2 vha-6 vha-6 catp-6 catp-6 mca-1 mca-1 tat-3 tat-3 tag-229 tag-229 sgk-1 sgk-1 catp-1 catp-1 exc-4 exc-4 spe-5 spe-5 clec-123 clec-123 best-20 best-20 vha-11 vha-11 vha-3 vha-3 ocr-4 ocr-4 Y45F10B.13 Y45F10B.13 clec-73 clec-73 Y47D7A.11 Y47D7A.11 Y48C3A.12 Y48C3A.12 vha-13 vha-13 tat-1 tat-1 Y51H7C.1 Y51H7C.1 Y51H7C.13 Y51H7C.13 Y53G8AR.9 Y53G8AR.9 vha-19 vha-19 anoh-2 anoh-2 Y57G11C.44 Y57G11C.44 catp-7 catp-7 mca-3 mca-3 egas-1 egas-1 egas-2 egas-2 egas-3 egas-3 Y6B3B.3 Y6B3B.3 cosa-1 cosa-1 sto-6 sto-6 sto-4 sto-4 best-21 best-21 cua-1 cua-1 trp-1 trp-1 best-22 best-22 ubq-2 ubq-2 pmr-1 pmr-1 cutc-1 cutc-1 ced-11 ced-11 unc-32 unc-32 best-23 best-23 best-24 best-24 asic-1 asic-1 best-25 best-25 best-26 best-26 vha-9 vha-9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
osm-9ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (937 aa)
eat-6Sodium/potassium-transporting ATPase subunit alpha. (996 aa)
clec-117C-type lectin domain-containing protein. (185 aa)
clh-2Chloride channel protein. (880 aa)
best-1Bestrophin homolog 1; Forms chloride channels. (450 aa)
best-2Bestrophin homolog 2; Forms chloride channels. (421 aa)
best-3Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (612 aa)
best-4Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (558 aa)
catp-4Sodium/potassium-transporting ATPase subunit alpha. (1015 aa)
catp-2Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1050 aa)
gtl-1LSDAT_euk domain-containing protein. (1694 aa)
C06E2.1Uncharacterized protein. (281 aa)
best-5Bestrophin homolog 5; Forms chloride channels. (453 aa)
clh-5Chloride channel protein. (797 aa)
best-6Bestrophin-6. (382 aa)
C09B9.85Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (555 aa)
catp-3Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1054 aa)
catp-8Probable manganese-transporting ATPase catp-8; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. (1178 aa)
unc-77Uncharacterized protein. (1867 aa)
kxd-1KxDL domain-containing protein. (140 aa)
nkb-1Sodium/potassium-transporting ATPase subunit beta-1; Non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). May also may function in the peptidic vesicle transport pathway from the endoplasmic reticulum for the defecation behaviors. (320 aa)
vha-8Vacuolar H ATPase. (226 aa)
del-9DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (579 aa)
C18H9.3GYF domain-containing protein gyf-1. (1106 aa)
delm-2DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (608 aa)
acd-1Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (635 aa)
acd-2Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (693 aa)
vha-7V-type proton ATPase subunit a. (1210 aa)
acd-3Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (484 aa)
nca-2Four domain-type voltage-gated ion channel alpha-1 subunit. (1785 aa)
trpa-1Transient receptor potential cation channel subfamily A member 1 homolog; Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. (1211 aa)
best-7Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (540 aa)
vha-16V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (348 aa)
C30G4.4Uncharacterized protein. (357 aa)
best-8Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (512 aa)
unc-105Degenerin-like protein unc-105; Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (962 aa)
nkb-2Na+/K+ ATPase, Beta subunit. (374 aa)
best-9Bestrophin homolog 9; Forms chloride channels. (399 aa)
wnk-1Serine/threonine-protein kinase WNK; Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals. (1850 aa)
deg-1Degenerin deg-1; Probable sodium channel subunit. Required by a subset of neurons. (778 aa)
best-10Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (423 aa)
best-11Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (444 aa)
C56G2.5Non-specific serine/threonine protein kinase. (713 aa)
del-1Degenerin del-1; Probable sodium channel subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (694 aa)
unc-79Uncoordinated protein 79. (2092 aa)
clh-3Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by [...] (1091 aa)
tat-6Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1064 aa)
flr-1FLR-1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (638 aa)
sto-1Stomatin-1. (330 aa)
pqn-29Prion-like-(Q/N-rich)-domain-bearing protein. (549 aa)
mec-2Mechanosensory protein 2; Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons. (1239 aa)
best-12Bestrophin homolog 12; Forms chloride channels. (434 aa)
mec-10Degenerin mec-10; Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (724 aa)
F17C8.6Uncharacterized protein. (279 aa)
vha-12Probable V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Required for necrotic cell death and epidermal cell fusion. (491 aa)
delm-1DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (626 aa)
unc-80Protein unc-80; Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane. (3263 aa)
degt-1DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (852 aa)
acd-4Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (613 aa)
ocr-1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (850 aa)
sto-2Stomatin-2; May be involved in cilia-related function. (375 aa)
best-13Bestrophin homolog 13; Forms chloride channels. (413 aa)
best-14Bestrophin homolog 14. (405 aa)
F33G12.6PPM-type phosphatase domain-containing protein. (771 aa)
F34H10.1Probable ribosomal protein F34H10.1; Belongs to the eukaryotic ribosomal protein eS31 family. (142 aa)
vha-5V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa)
tat-5Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1074 aa)
F37C4.8Uncharacterized protein. (343 aa)
csq-1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (417 aa)
F41E6.11Uncharacterized protein. (316 aa)
F41E7.1Na_H_Exchanger domain-containing protein. (516 aa)
F41E7.2Na_H_Exchanger domain-containing protein. (558 aa)
cup-15Coelomocyte uptake defective protein 15; Modulates the transport of substances from the endosomal to lysosomal compartments. Plays a role in lysosome formation and function in coelomocytes. (322 aa)
ttyh-1Protein tweety homolog 1; Probable chloride channel. (519 aa)
vha-10Probable V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (126 aa)
clec-79C-type lectin domain-containing protein. (575 aa)
vha-17V-type proton ATPase subunit e; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (86 aa)
vha-18Probable V-type proton ATPase subunit H 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (451 aa)
gtl-2Gon-Two Like (TRP subfamily). (1406 aa)
nkb-3Probable sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). Implicated in genomic response to various soil bacteria that affects fitness, lifespan and brood size. (317 aa)
egas-4EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (883 aa)
vha-14V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase D subunit family. (257 aa)
anoh-1Anoctamin. (840 aa)
F57G8.5Na_H_Exchanger domain-containing protein. (498 aa)
unc-24PHB domain-containing protein. (443 aa)
F58G6.8Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (198 aa)
del-5DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (526 aa)
tat-2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1349 aa)
ubl-1Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family. (163 aa)
H17B01.2Uncharacterized protein. (466 aa)
spe-41TRP homologous cation channel protein. (854 aa)
mbl-1Muscleblind-like protein; Binds to RNA with repeat sequences 5'-CUG-3' and 5'-CCUG-3'. (324 aa)
unc-1Protein unc-1. (289 aa)
catp-5Cation-transporting ATPase catp-5; Involved in the uptake and/or transport of polyamines, probably through ATP hydrolysis. This contributes to the maintenance of intracellular polyamine levels. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. (1203 aa)
K08C9.7Uncharacterized protein. (154 aa)
K09A9.6TPR_REGION domain-containing protein. (920 aa)
unc-68Uncharacterized protein. (5202 aa)
sca-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1059 aa)
unc-43Calcium/calmodulin-dependent protein kinase type II; Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the [...] (681 aa)
K11H3.8GYF domain-containing protein. (355 aa)
mca-2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1158 aa)
trp-2TRP (Transient receptor potential) channel family; Belongs to the transient receptor (TC 1.A.4) family. (886 aa)
clh-6Chloride channel protein. (796 aa)
clec-175C-type lectin domain-containing protein. (569 aa)
sao-1Suppressor of aph-1; Involved in negative regulation of early and late embryonic Notch signaling. (245 aa)
vha-2V-type proton ATPase 16 kDa proteolipid subunit 2; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase (By similarity). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Involved in necrotic cell death. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occ [...] (161 aa)
vha-1V-type proton ATPase 16 kDa proteolipid subunit 1; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-AT [...] (169 aa)
best-15Bestrophin homolog 15; Forms chloride channels. (525 aa)
unc-8Degenerin unc-8. (778 aa)
best-16Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (463 aa)
cup-5PKD_channel domain-containing protein. (668 aa)
R144.11Uncharacterized protein. (307 aa)
mec-4Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior. (768 aa)
vha-4Vacuolar H ATPase. (214 aa)
gon-2Transient receptor potential channel; Required for initiation and continuation of postembryonic mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. May be a cation channel. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. (2032 aa)
clh-4Chloride channel protein. (1085 aa)
ocr-2ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (900 aa)
ocr-3ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (818 aa)
T13G4.1GYF domain-containing protein. (163 aa)
vha-15Probable V-type proton ATPase subunit H 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). (470 aa)
T18D3.7Uncharacterized protein T18D3.7; Belongs to the TSC-22/Dip/Bun family. (269 aa)
T19B10.2Uncharacterized protein. (368 aa)
best-17Bestrophin homolog 17; Forms chloride channels. (501 aa)
best-18Bestrophin homolog 18; Forms chloride channels. (456 aa)
best-19Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (569 aa)
tat-4Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1454 aa)
clh-1Chloride channel protein. (906 aa)
del-4DEgenerin Like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (527 aa)
del-10Degenerin-like protein del-10. (1069 aa)
acd-5Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (714 aa)
asic-2Degenerin-like protein asic-2. (545 aa)
vha-6V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (865 aa)
catp-6Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1256 aa)
mca-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1252 aa)
tat-3Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1411 aa)
tag-229YccV-like domain-containing protein. (200 aa)
sgk-1Serine/threonine-protein kinase sgk-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead- related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Acts downstream of rict-1 to regulate fat storage, size, and development. Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development. Does not appear to pla [...] (463 aa)
catp-1Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1121 aa)
exc-4Chloride intracellular channel exc-4; May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows. (290 aa)
spe-5Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (501 aa)
clec-123C-type LECtin. (578 aa)
best-20Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (486 aa)
vha-11V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Has roles in embryogenesis and ovulation. (384 aa)
vha-3V-type proton ATPase 16 kDa proteolipid subunit 2/3. (161 aa)
ocr-4ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (756 aa)
Y45F10B.13Uncharacterized protein. (633 aa)
clec-73C-type lectin domain-containing protein. (577 aa)
Y47D7A.11Uncharacterized protein. (129 aa)
Y48C3A.12Uncharacterized protein. (675 aa)
vha-13V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (Probable). V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (Probable). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-A [...] (606 aa)
tat-1Phospholipid-transporting ATPase tat-1; Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes. Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintainence and control of the membrane surface charge. Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifica [...] (1192 aa)
Y51H7C.1Uncharacterized protein. (448 aa)
Y51H7C.13Uncharacterized protein. (344 aa)
Y53G8AR.9Uncharacterized protein. (315 aa)
vha-19Vacuolar H ATPase. (451 aa)
anoh-2Anoctamin. (893 aa)
Y57G11C.44Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (155 aa)
catp-7Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1127 aa)
mca-3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1234 aa)
egas-1EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (938 aa)
egas-2EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (919 aa)
egas-3EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (921 aa)
Y6B3B.3WSN domain-containing protein. (1107 aa)
cosa-1CrossOver Site Associated. (360 aa)
sto-6PHB domain-containing protein. (298 aa)
sto-4Stomatin-4. (281 aa)
best-21Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (395 aa)
cua-1Copper transporting ATPase. (1238 aa)
trp-1Transient-receptor-potential-like protein; Could mediate calcium entry and form a calcium permeant channel; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. (1047 aa)
best-22Bestrophin homolog 22; Forms chloride channels. (510 aa)
ubq-2Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] (128 aa)
pmr-1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (978 aa)
cutc-1Copper homeostasis protein cutC homolog; Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size; Belongs to the CutC family. (250 aa)
ced-11Protein ced-11; Plays a major role in programmed cell death. (1418 aa)
unc-32Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development. (905 aa)
best-23Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (405 aa)
best-24Bestrophin homolog 24; Forms chloride channels. (632 aa)
asic-1Degenerin-like protein asic-1; Proton-gated cation channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions (By similarity). (823 aa)
best-25Bestrophin homolog 25; Forms chloride channels. (602 aa)
best-26Bestrophin homolog 26; Forms chloride channels. (411 aa)
vha-9Probable V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function (Probable). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (Probable). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of [...] (121 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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