14 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gpc-2	G protein gamma domain-containing protein. (62 aa)
	acy-3	Adenylyl CYclase. (1243 aa)
	acy-2	Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1080 aa)
	irk-1	Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. (544 aa)
	irk-2	Inward Rectifying K (Potassium) channel family. (497 aa)
	gpc-1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa)
	acy-4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
	gbb-1	Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...] (899 aa)
	Y94H6A.12	Uncharacterized protein. (120 aa)
	Y94H6A.7	LMWPc domain-containing protein. (164 aa)
	gbb-2	Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...] (842 aa)
	gpb-2	Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa)
	acy-1	Adenylyl CYclase. (1253 aa)
	gpb-1	Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Y94H6A.12	Y94H6A.7	Y94H6A.12a.2	Y94H6A.7.1	Uncharacterized protein.	LMWPc domain-containing protein.	0.608
Y94H6A.7	Y94H6A.12	Y94H6A.7.1	Y94H6A.12a.2	LMWPc domain-containing protein.	Uncharacterized protein.	0.608
acy-1	acy-2	F17C8.1.1	C10F3.3.1	Adenylyl CYclase.	Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.484
acy-1	acy-3	F17C8.1.1	C44F1.5.2	Adenylyl CYclase.	Adenylyl CYclase.	0.463
acy-1	acy-4	F17C8.1.1	T01C2.1.1	Adenylyl CYclase.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.543
acy-1	gpb-1	F17C8.1.1	F13D12.7a.1	Adenylyl CYclase.	Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces.	0.651
acy-1	gpb-2	F17C8.1.1	F52A8.2a.1	Adenylyl CYclase.	Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.791
acy-1	gpc-1	F17C8.1.1	K02A4.2.3	Adenylyl CYclase.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.712
acy-1	gpc-2	F17C8.1.1	F08B6.2.1	Adenylyl CYclase.	G protein gamma domain-containing protein.	0.679
acy-2	acy-1	C10F3.3.1	F17C8.1.1	Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylyl CYclase.	0.484
acy-2	gpb-1	C10F3.3.1	F13D12.7a.1	Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces.	0.631
acy-2	gpb-2	C10F3.3.1	F52A8.2a.1	Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.681
acy-2	gpc-1	C10F3.3.1	K02A4.2.3	Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.697
acy-2	gpc-2	C10F3.3.1	F08B6.2.1	Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	G protein gamma domain-containing protein.	0.646
acy-3	acy-1	C44F1.5.2	F17C8.1.1	Adenylyl CYclase.	Adenylyl CYclase.	0.463
acy-3	gpb-2	C44F1.5.2	F52A8.2a.1	Adenylyl CYclase.	Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.403
acy-3	gpc-1	C44F1.5.2	K02A4.2.3	Adenylyl CYclase.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.433
acy-4	acy-1	T01C2.1.1	F17C8.1.1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylyl CYclase.	0.543
acy-4	gpb-1	T01C2.1.1	F13D12.7a.1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces.	0.546
acy-4	gpb-2	T01C2.1.1	F52A8.2a.1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.546