STRINGSTRING
nphp-4 nphp-4 Y55D5A.1 Y55D5A.1 Y44A6D.2 Y44A6D.2 mig-1 mig-1 bbs-1 bbs-1 spp-5 spp-5 ugt-50 ugt-50 rol-6 rol-6 unc-8 unc-8 osm-6 osm-6 gcy-6 gcy-6 C35E7.11 C35E7.11 odr-10 odr-10 lmn-1 lmn-1 del-1 del-1 F10G2.1 F10G2.1 unc-54 unc-54 eef-1A.1 eef-1A.1 daf-19 daf-19 tax-2 tax-2 acr-5 acr-5 K10D6.2 K10D6.2 K10G6.4 K10G6.4 myo-3 myo-3 nphp-1 nphp-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nphp-4NePHronoPhthisis (Human kidney disease) homolog. (1305 aa)
Y55D5A.1Uncharacterized protein. (285 aa)
Y44A6D.2Uncharacterized protein. (76 aa)
mig-1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
bbs-1Bardet-Biedl syndrome 1 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. (576 aa)
spp-5Saposin B-type domain-containing protein. (103 aa)
ugt-50Putative UDP-glucuronosyltransferase ugt-50. (523 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
unc-8Degenerin unc-8. (778 aa)
osm-6Osm-6 protein. (472 aa)
gcy-6Receptor-type guanylate cyclase gcy-6; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg(2+) and to a lesser extent toward Cl(1-) in ASE left (ASEL) sensory neuron. (1086 aa)
C35E7.11Uncharacterized protein. (129 aa)
odr-10Serpentine receptor class r-10; An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway; Belongs to the nematode receptor-like protein str family. (339 aa)
lmn-1Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. (566 aa)
del-1Degenerin del-1; Probable sodium channel subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (694 aa)
F10G2.1UPF0376 protein F10G2.1. (201 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
eef-1A.1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (463 aa)
daf-19RFX-like transcription factor daf-19; May be a transcription factor that regulates some genes of ciliated sensory neurons. May activate the expression of the shared components of sensory cilia, but not the cell-type-specific expression; Belongs to the RFX family. (805 aa)
tax-2Cyclic nucleotide-binding domain-containing protein. (800 aa)
acr-5Acetylcholine receptor subunit alpha-type acr-5; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (598 aa)
K10D6.2Uncharacterized protein. (287 aa)
K10G6.4Uncharacterized protein. (459 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
nphp-1Nephrocystin-1-like protein; May be necessary for initial assembly of the cilium. (682 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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