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dpy-20 dpy-20 unc-5 unc-5 vha-8 vha-8 vha-7 vha-7 nex-3 nex-3 wrt-8 wrt-8 vit-2 vit-2 rme-8 rme-8 vha-5 vha-5 dpy-7 dpy-7 wrt-2 wrt-2 che-14 che-14 unc-24 unc-24 vha-1 vha-1 cup-5 cup-5 rol-6 rol-6 vha-4 vha-4 nex-2 nex-2 act-5 act-5 vha-6 vha-6 grd-3 grd-3 vha-13 vha-13 nex-1 nex-1 wrt-1 wrt-1 unc-32 unc-32
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dpy-20Protein dumpy-20; May be directly or indirectly involved in cuticle function. (440 aa)
unc-5Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. (947 aa)
vha-8Vacuolar H ATPase. (226 aa)
vha-7V-type proton ATPase subunit a. (1210 aa)
nex-3Annexin. (317 aa)
wrt-8Warthog protein 8 C-product; Intercellular signal essential for a variety of patterning events during development. (550 aa)
vit-2Vitellogenin-2; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1613 aa)
rme-8J domain-containing protein. (2279 aa)
vha-5V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa)
dpy-7Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape. (318 aa)
wrt-2WaRThog (Hedgehog-like family). (454 aa)
che-14SSD domain-containing protein. (917 aa)
unc-24PHB domain-containing protein. (443 aa)
vha-1V-type proton ATPase 16 kDa proteolipid subunit 1; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-AT [...] (169 aa)
cup-5PKD_channel domain-containing protein. (668 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
vha-4Vacuolar H ATPase. (214 aa)
nex-2Annexin. (497 aa)
act-5ACTin. (375 aa)
vha-6V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (865 aa)
grd-3Ground-like domain-containing protein. (181 aa)
vha-13V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (Probable). V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (Probable). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-A [...] (606 aa)
nex-1Annexin. (322 aa)
wrt-1Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. (484 aa)
unc-32Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development. (905 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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