node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
mig-22 | sqv-5 | PAR2.4a.3 | T24D1.1c.1 | Chondroitin sulfate synthase mig-22; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc- 6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransfera [...] | Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...] | 0.973 |
sqv-5 | mig-22 | T24D1.1c.1 | PAR2.4a.3 | Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...] | Chondroitin sulfate synthase mig-22; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc- 6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransfera [...] | 0.973 |
sqv-5 | unc-40 | T24D1.1c.1 | T19B4.7.1 | Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...] | Unc-40 protein. | 0.460 |
sqv-5 | unc-6 | T24D1.1c.1 | F41C6.1.1 | Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...] | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | 0.460 |
unc-40 | sqv-5 | T19B4.7.1 | T24D1.1c.1 | Unc-40 protein. | Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...] | 0.460 |
unc-40 | unc-5 | T19B4.7.1 | B0273.4c.1 | Unc-40 protein. | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | 0.997 |
unc-40 | unc-6 | T19B4.7.1 | F41C6.1.1 | Unc-40 protein. | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | 0.999 |
unc-5 | unc-40 | B0273.4c.1 | T19B4.7.1 | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | Unc-40 protein. | 0.997 |
unc-5 | unc-6 | B0273.4c.1 | F41C6.1.1 | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | 0.999 |
unc-6 | sqv-5 | F41C6.1.1 | T24D1.1c.1 | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...] | 0.460 |
unc-6 | unc-40 | F41C6.1.1 | T19B4.7.1 | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | Unc-40 protein. | 0.999 |
unc-6 | unc-5 | F41C6.1.1 | B0273.4c.1 | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG. | 0.999 |