STRINGSTRING
wrt-9 wrt-9 grd-9 grd-9 nas-37 nas-37 grl-20 grl-20 grl-1 grl-1 nas-36 nas-36 grl-10 grl-10 wrt-8 wrt-8 grd-8 grd-8 grl-17 grl-17 grl-23 grl-23 grd-12 grd-12 ptd-2 ptd-2 grd-10 grd-10 grl-24 grl-24 dpy-5 dpy-5 cfz-2 cfz-2 grl-12 grl-12 daf-6 daf-6 grl-13 grl-13 F40C5.1 F40C5.1 grl-27 grl-27 grd-5 grd-5 grl-4 grl-4 grd-2 grd-2 grd-7 grd-7 che-14 che-14 gpn-1 gpn-1 grl-26 grl-26 grd-11 grd-11 grl-3 grl-3 grl-6 grl-6 grl-19 grl-19 grd-1 grd-1 grd-4 grd-4 grd-14 grd-14 rol-6 rol-6 grl-7 grl-7 grl-14 grl-14 cpl-1 cpl-1 qua-1 qua-1 grl-18 grl-18 grl-2 grl-2 grd-6 grd-6 mom-5 mom-5 grl-28 grl-28 grl-29 grl-29 grl-31 grl-31 grl-30 grl-30 grl-22 grl-22 wrt-5 wrt-5 grd-3 grd-3 grd-13 grd-13 hog-1 hog-1 tra-1 tra-1 grl-5 grl-5 grl-16 grl-16 grd-16 grd-16 grl-15 grl-15 grl-21 grl-21 grl-9 grl-9 grl-8 grl-8 wrt-7 wrt-7 wrt-1 wrt-1 wrt-10 wrt-10 grl-11 grl-11 grl-25 grl-25 ptc-1 ptc-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wrt-9WaRThog (Hedgehog-like family). (553 aa)
grd-9Ground-like domain-containing protein. (588 aa)
nas-37Zinc metalloproteinase nas-37; Metalloprotease (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Required during ecdysis, the opening of the cuticle to allow the worm to escape. (765 aa)
grl-20Ground-like domain-containing protein. (163 aa)
grl-1Ground-like domain-containing protein. (348 aa)
nas-36Zinc metalloproteinase nas-36; Metalloprotease (By similarity). Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. (617 aa)
grl-10Ground-like domain-containing protein. (282 aa)
wrt-8Warthog protein 8 C-product; Intercellular signal essential for a variety of patterning events during development. (550 aa)
grd-8Ground-like domain-containing protein. (373 aa)
grl-17Ground-like domain-containing protein. (393 aa)
grl-23GRound-Like (Grd related). (385 aa)
grd-12Ground-like domain-containing protein. (285 aa)
ptd-2SSD domain-containing protein. (936 aa)
grd-10Ground-like domain-containing protein. (102 aa)
grl-24Ground-like domain-containing protein. (103 aa)
dpy-5Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (284 aa)
cfz-2Frizzled-2; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta- catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to inv [...] (578 aa)
grl-12Ground-like domain-containing protein. (186 aa)
daf-6SSD domain-containing protein. (913 aa)
grl-13Ground-like domain-containing protein. (273 aa)
F40C5.1Uncharacterized protein. (309 aa)
grl-27Ground-like domain-containing protein. (139 aa)
grd-5Ground-like domain-containing protein. (102 aa)
grl-4Ground-like domain-containing protein. (210 aa)
grd-2GRounDhog (Hedgehog-like family). (946 aa)
grd-7Ground-like domain-containing protein. (416 aa)
che-14SSD domain-containing protein. (917 aa)
gpn-1GlyPicaN; Belongs to the glypican family. (543 aa)
grl-26Ground-like domain-containing protein. (140 aa)
grd-11GRounDhog (Hedgehog-like family). (977 aa)
grl-3Ground-like domain-containing protein. (284 aa)
grl-6Ground-like domain-containing protein. (240 aa)
grl-19Ground-like domain-containing protein. (157 aa)
grd-1GRounDhog (Hedgehog-like family). (1160 aa)
grd-4Ground-like domain-containing protein. (169 aa)
grd-14GRounDhog (Hedgehog-like family). (154 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
grl-7Ground-like domain-containing protein. (352 aa)
grl-14Ground-like domain-containing protein. (440 aa)
cpl-1Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...] (337 aa)
qua-1Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development. (1169 aa)
grl-18Ground-like domain-containing protein. (445 aa)
grl-2Ground-like domain-containing protein. (365 aa)
grd-6Ground-like domain-containing protein. (614 aa)
mom-5Protein mom-5; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). B [...] (570 aa)
grl-28Ground-like domain-containing protein. (139 aa)
grl-29Ground-like domain-containing protein. (172 aa)
grl-31Ground-like domain-containing protein. (156 aa)
grl-30Ground-like domain-containing protein. (140 aa)
grl-22Ground-like domain-containing protein. (162 aa)
wrt-5Warthog protein 5; Intercellular signal essential for a variety of patterning events during development. (176 aa)
grd-3Ground-like domain-containing protein. (181 aa)
grd-13GRounDhog (Hedgehog-like family). (156 aa)
hog-1HOG only (Hedgehog Hog domain alone). (245 aa)
tra-1Sex-determining transformer protein 1; Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By s [...] (1110 aa)
grl-5Ground-like domain-containing protein. (220 aa)
grl-16Ground-like domain-containing protein. (453 aa)
grd-16GRounDhog (Hedgehog-like family). (404 aa)
grl-15Ground-like domain-containing protein. (169 aa)
grl-21Ground-like domain-containing protein. (172 aa)
grl-9Ground-like domain-containing protein. (318 aa)
grl-8Ground-like domain-containing protein. (212 aa)
wrt-7WaRThog (Hedgehog-like family). (481 aa)
wrt-1Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development. (484 aa)
wrt-10WaRThog (Hedgehog-like family). (258 aa)
grl-11Ground-like domain-containing protein. (136 aa)
grl-25GRound-Like (Grd related). (774 aa)
ptc-1Protein patched homolog 1; Required but not essential for cytokinesis of mitotically proliferating germ cells. (1408 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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