Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| act-5 | ajm-1 | T25C8.2.2 | C25A11.4f.1 | ACTin. | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | 0.717 |
| act-5 | baf-1 | T25C8.2.2 | B0464.7.1 | ACTin. | Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family. | 0.688 |
| act-5 | lmn-1 | T25C8.2.2 | DY3.2.2 | ACTin. | Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. | 0.723 |
| act-5 | sun-1 | T25C8.2.2 | F57B1.2.1 | ACTin. | Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. | 0.828 |
| act-5 | unc-27 | T25C8.2.2 | ZK721.2.1 | ACTin. | Troponin I 2; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity. | 0.636 |
| act-5 | unc-52 | T25C8.2.2 | ZC101.2e.1 | ACTin. | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. | 0.572 |
| act-5 | unc-54 | T25C8.2.2 | F11C3.3.2 | ACTin. | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.855 |
| aff-1 | ajm-1 | C44B7.3.1 | C25A11.4f.1 | Cell fusion protein aff-1; Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells. Required for amphid sheath cell fusion induced by entry into dauer stage. | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | 0.453 |
| ajm-1 | act-5 | C25A11.4f.1 | T25C8.2.2 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | ACTin. | 0.717 |
| ajm-1 | aff-1 | C25A11.4f.1 | C44B7.3.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Cell fusion protein aff-1; Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells. Required for amphid sheath cell fusion induced by entry into dauer stage. | 0.453 |
| ajm-1 | cdh-3 | C25A11.4f.1 | ZK112.7.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Cadherin-3; Cell adhesion protein involved in the control of epithelial morphogenesis. Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development. | 0.628 |
| ajm-1 | unc-52 | C25A11.4f.1 | ZC101.2e.1 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. | 0.421 |
| ajm-1 | unc-54 | C25A11.4f.1 | F11C3.3.2 | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.571 |
| baf-1 | act-5 | B0464.7.1 | T25C8.2.2 | Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family. | ACTin. | 0.688 |
| baf-1 | emr-1 | B0464.7.1 | M01D7.6.1 | Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family. | Emerin homolog 1; Involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with lem-2. May play a role in radiation- induced DNA damage repair response. | 0.900 |
| baf-1 | lap-2 | B0464.7.1 | W07G4.4.1 | Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family. | Putative aminopeptidase W07G4.4. | 0.764 |
| baf-1 | lem-2 | B0464.7.1 | W01G7.5.1 | Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family. | LEM protein 2; Essential protein involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with emr-1. May play a role in radiation-induced DNA damage repair response. | 0.968 |
| baf-1 | lmn-1 | B0464.7.1 | DY3.2.2 | Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family. | Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family. | 0.972 |
| baf-1 | sun-1 | B0464.7.1 | F57B1.2.1 | Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family. | Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos. | 0.786 |
| cdh-3 | ajm-1 | ZK112.7.1 | C25A11.4f.1 | Cadherin-3; Cell adhesion protein involved in the control of epithelial morphogenesis. Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development. | Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. | 0.628 |
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