STRINGSTRING
ser-2 ser-2 cam-1 cam-1 mig-1 mig-1 unc-52 unc-52 pat-3 pat-3 eat-4 eat-4 lev-10 lev-10 unc-63 unc-63 act-5 act-5 dpy-20 dpy-20 lam-3 lam-3 dgn-1 dgn-1 unc-29 unc-29 rol-6 rol-6 myo-3 myo-3 dig-1 dig-1 nid-1 nid-1 pat-2 pat-2 dyb-1 dyb-1 agr-1 agr-1 acr-16 acr-16 unc-38 unc-38 dys-1 dys-1 eat-5 eat-5 lev-1 lev-1 cle-1 cle-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ser-2Tyramine receptor Ser-2; G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. The rank order of potency is tyramine > octopamine > dopamine > serotonin > epinephrine = norepinephrine. (455 aa)
cam-1Tyrosine-protein kinase receptor cam-1; Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom- 2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn- 2, [...] (928 aa)
mig-1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
unc-52Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa)
pat-3Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa)
eat-4Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa)
lev-10LEV-10A protein. (906 aa)
unc-63Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. (502 aa)
act-5ACTin. (375 aa)
dpy-20Protein dumpy-20; May be directly or indirectly involved in cuticle function. (440 aa)
lam-3LAMinin related. See also lmb. (3102 aa)
dgn-1Peptidase S72 domain-containing protein. (584 aa)
unc-29Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
dig-1Mesocentin; Encodes an adhesion molecule involved in sensory map formation. Functions during sensory process development in the nervous system. (13100 aa)
nid-1NIDogen (Basement membrane protein). (1584 aa)
pat-2Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...] (1226 aa)
dyb-1Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance. (590 aa)
agr-1AGRin (Synaptic protein) homolog family member. (1473 aa)
acr-16Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor. (498 aa)
unc-38Acetylcholine receptor subunit alpha-type unc-38; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (511 aa)
dys-1Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa)
eat-5Innexin eat-5; Structural component of the gap junctions (By similarity). Required for synchronized pharyngeal muscle contractions. Belongs to the pannexin family. (423 aa)
lev-1Acetylcholine receptor subunit beta-type lev-1; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (507 aa)
cle-1CoLlagen with Endostatin domain. (1175 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (16%) [HD]