node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hda-10 | hda-11 | Y51H1A.5.1 | C35A5.9.1 | Hist_deacetyl domain-containing protein. | Hist_deacetyl domain-containing protein. | 0.621 |
hda-10 | hda-3 | Y51H1A.5.1 | R06C1.1.1 | Hist_deacetyl domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.749 |
hda-10 | sir-2.1 | Y51H1A.5.1 | R11A8.4a.1 | Hist_deacetyl domain-containing protein. | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | 0.663 |
hda-11 | hda-10 | C35A5.9.1 | Y51H1A.5.1 | Hist_deacetyl domain-containing protein. | Hist_deacetyl domain-containing protein. | 0.621 |
hda-11 | hda-3 | C35A5.9.1 | R06C1.1.1 | Hist_deacetyl domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.519 |
hda-11 | hda-5 | C35A5.9.1 | F43G6.11.1 | Hist_deacetyl domain-containing protein. | Hist_deacetyl domain-containing protein. | 0.542 |
hda-11 | sir-2.1 | C35A5.9.1 | R11A8.4a.1 | Hist_deacetyl domain-containing protein. | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | 0.714 |
hda-3 | hda-10 | R06C1.1.1 | Y51H1A.5.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Hist_deacetyl domain-containing protein. | 0.749 |
hda-3 | hda-11 | R06C1.1.1 | C35A5.9.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Hist_deacetyl domain-containing protein. | 0.519 |
hda-3 | hda-5 | R06C1.1.1 | F43G6.11.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Hist_deacetyl domain-containing protein. | 0.633 |
hda-3 | sir-2.1 | R06C1.1.1 | R11A8.4a.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | 0.741 |
hda-5 | hda-11 | F43G6.11.1 | C35A5.9.1 | Hist_deacetyl domain-containing protein. | Hist_deacetyl domain-containing protein. | 0.542 |
hda-5 | hda-3 | F43G6.11.1 | R06C1.1.1 | Hist_deacetyl domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.633 |
hda-5 | sir-2.1 | F43G6.11.1 | R11A8.4a.1 | Hist_deacetyl domain-containing protein. | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | 0.433 |
sir-2.1 | hda-10 | R11A8.4a.1 | Y51H1A.5.1 | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | Hist_deacetyl domain-containing protein. | 0.663 |
sir-2.1 | hda-11 | R11A8.4a.1 | C35A5.9.1 | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | Hist_deacetyl domain-containing protein. | 0.714 |
sir-2.1 | hda-3 | R11A8.4a.1 | R06C1.1.1 | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.741 |
sir-2.1 | hda-5 | R11A8.4a.1 | F43G6.11.1 | NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...] | Hist_deacetyl domain-containing protein. | 0.433 |