STRINGSTRING
parg-2 parg-2 pdr-1 pdr-1 dnj-19 dnj-19 act-5 act-5 vps-24 vps-24 vps-28 vps-28 hsp-70 hsp-70 sft-4 sft-4 pink-1 pink-1 vps-60 vps-60 F57B10.5 F57B10.5 ccz-1 ccz-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
parg-2Poly(ADP-ribose) glycohydrolase 2; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells (By similarity). (485 aa)
pdr-1E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (386 aa)
dnj-19DNaJ domain (Prokaryotic heat shock protein). (439 aa)
act-5ACTin. (375 aa)
vps-24Related to yeast Vacuolar Protein Sorting factor. (208 aa)
vps-28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
sft-4Surfeit locus protein 4 homolog; Belongs to the SURF4 family. (277 aa)
pink-1Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy. (641 aa)
vps-60Related to yeast Vacuolar Protein Sorting factor. (217 aa)
F57B10.5GOLD domain-containing protein. (203 aa)
ccz-1Uncharacterized protein. (528 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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