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unc-57 | Endophilin-A homolog; Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis. By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion. In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels. Plays a minor role in responses to mechanical stimuli. Plays a minor role in unc- 26/synaptojanin localization to synapses. (381 aa) | ||||
snb-1 | Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function. (109 aa) | ||||
dhc-1 | Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). May play a role in nuclear migration in hypodermal precursor cells. May be involved in the transport of synaptic vesicle components towards the axon of the DA motor neuron. This function may involve the regulation of dynein by pct-1 and/or cdk-5. Involved in the formation of synapses in the dorsal regi [...] (4568 aa) | ||||
rab-10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa) | ||||
rab-7 | RAB family. (209 aa) | ||||
dhc-4 | DHC_N2 domain-containing protein. (2727 aa) | ||||
unc-25 | Glutamic acid decarboxylase. (508 aa) | ||||
unc-16 | JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] (1190 aa) | ||||
dhc-3 | Dynein Heavy Chain. (3275 aa) | ||||
jnk-1 | Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] (463 aa) | ||||
rab-3 | Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa) | ||||
klc-2 | Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. (540 aa) | ||||
unc-11 | Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family. (657 aa) | ||||
unc-104 | Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...] (1628 aa) | ||||
rab-5 | RAB family. (208 aa) | ||||
jkk-1 | Dual specificity mitogen-activated protein kinase kinase jkk-1; Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy meta [...] (435 aa) | ||||
unc-26 | Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa) | ||||
sek-1 | Dual specificity mitogen-activated protein kinase kinase sek-1; Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir- 1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive [...] (336 aa) | ||||
unc-116 | Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites. (815 aa) | ||||
eea-1 | FYVE-type domain-containing protein. (1205 aa) |