node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
T24B8.2 | spas-1 | T24B8.2.1 | C24B5.2c.1 | Charged Multivesicular Body Protein homolog. | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. | 0.957 |
T24B8.2 | vps-20 | T24B8.2.1 | Y65B4A.3.1 | Charged Multivesicular Body Protein homolog. | Related to yeast Vacuolar Protein Sorting factor. | 0.979 |
T24B8.2 | vps-24 | T24B8.2.1 | T27F7.1.2 | Charged Multivesicular Body Protein homolog. | Related to yeast Vacuolar Protein Sorting factor. | 0.977 |
T24B8.2 | vps-25 | T24B8.2.1 | W02A11.2.2 | Charged Multivesicular Body Protein homolog. | Related to yeast Vacuolar Protein Sorting factor. | 0.970 |
T24B8.2 | vps-28 | T24B8.2.1 | Y87G2A.10a.1 | Charged Multivesicular Body Protein homolog. | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. | 0.922 |
T24B8.2 | vps-36 | T24B8.2.1 | F17C11.8.2 | Charged Multivesicular Body Protein homolog. | GLUE N-terminal domain-containing protein. | 0.762 |
T24B8.2 | vps-4 | T24B8.2.1 | Y34D9A.10.1 | Charged Multivesicular Body Protein homolog. | Related to yeast Vacuolar Protein Sorting factor; Belongs to the AAA ATPase family. | 0.750 |
T24B8.2 | vps-60 | T24B8.2.1 | F41E6.9.1 | Charged Multivesicular Body Protein homolog. | Related to yeast Vacuolar Protein Sorting factor. | 0.968 |
let-23 | rme-2 | ZK1067.1d.1 | T11F8.3a.1 | Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] | Receptor Mediated Endocytosis. | 0.881 |
rme-2 | let-23 | T11F8.3a.1 | ZK1067.1d.1 | Receptor Mediated Endocytosis. | Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] | 0.881 |
spas-1 | T24B8.2 | C24B5.2c.1 | T24B8.2.1 | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. | Charged Multivesicular Body Protein homolog. | 0.957 |
spas-1 | vps-20 | C24B5.2c.1 | Y65B4A.3.1 | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. | Related to yeast Vacuolar Protein Sorting factor. | 0.783 |
spas-1 | vps-24 | C24B5.2c.1 | T27F7.1.2 | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. | Related to yeast Vacuolar Protein Sorting factor. | 0.879 |
spas-1 | vps-4 | C24B5.2c.1 | Y34D9A.10.1 | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. | Related to yeast Vacuolar Protein Sorting factor; Belongs to the AAA ATPase family. | 0.577 |
spas-1 | vps-60 | C24B5.2c.1 | F41E6.9.1 | Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. | Related to yeast Vacuolar Protein Sorting factor. | 0.465 |
vps-11 | vps-18 | R06F6.2.1 | W06B4.3.1 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] | 0.999 |
vps-11 | vps-28 | R06F6.2.1 | Y87G2A.10a.1 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. | 0.554 |
vps-11 | vps-8 | R06F6.2.1 | C42C1.4a.1 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] | Vps8 domain-containing protein. | 0.999 |
vps-18 | vps-11 | W06B4.3.1 | R06F6.2.1 | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] | 0.999 |
vps-18 | vps-25 | W06B4.3.1 | W02A11.2.2 | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] | Related to yeast Vacuolar Protein Sorting factor. | 0.628 |