STRINGSTRING
dhc-3 dhc-3 spas-1 spas-1 vps-8 vps-8 vps-36 vps-36 vps-60 vps-60 smf-1 smf-1 vps-11 vps-11 rme-2 rme-2 T24B8.2 T24B8.2 vps-24 vps-24 vps-25 vps-25 dhc-4 dhc-4 vps-18 vps-18 vps-4 vps-4 vps-20 vps-20 vps-28 vps-28 let-23 let-23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dhc-3Dynein Heavy Chain. (3275 aa)
spas-1Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily. (512 aa)
vps-8Vps8 domain-containing protein. (1259 aa)
vps-36GLUE N-terminal domain-containing protein. (383 aa)
vps-60Related to yeast Vacuolar Protein Sorting factor. (217 aa)
smf-1NRAMP-like transporter smf-1; Probable divalent metal ion transporter which regulates Mn(2+) uptake; Belongs to the NRAMP family. (562 aa)
vps-11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...] (980 aa)
rme-2Receptor Mediated Endocytosis. (925 aa)
T24B8.2Charged Multivesicular Body Protein homolog. (411 aa)
vps-24Related to yeast Vacuolar Protein Sorting factor. (208 aa)
vps-25Related to yeast Vacuolar Protein Sorting factor. (183 aa)
dhc-4DHC_N2 domain-containing protein. (2727 aa)
vps-18Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa)
vps-4Related to yeast Vacuolar Protein Sorting factor; Belongs to the AAA ATPase family. (430 aa)
vps-20Related to yeast Vacuolar Protein Sorting factor. (208 aa)
vps-28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa)
let-23Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] (1335 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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