node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | daf-16 | T25C8.2.2 | R13H8.1h.1 | ACTin. | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | 0.823 |
act-5 | hop-1 | T25C8.2.2 | C18E3.8.1 | ACTin. | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | 0.484 |
act-5 | sel-12 | T25C8.2.2 | F35H12.3.1 | ACTin. | Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. | 0.445 |
act-5 | spe-4 | T25C8.2.2 | ZK524.1.1 | ACTin. | Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. | 0.439 |
act-5 | sph-1 | T25C8.2.2 | F42G8.11.1 | ACTin. | MARVEL domain-containing protein. | 0.749 |
daf-16 | act-5 | R13H8.1h.1 | T25C8.2.2 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | ACTin. | 0.823 |
hda-10 | hda-11 | Y51H1A.5.1 | C35A5.9.1 | Hist_deacetyl domain-containing protein. | Hist_deacetyl domain-containing protein. | 0.621 |
hda-10 | hda-3 | Y51H1A.5.1 | R06C1.1.1 | Hist_deacetyl domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.749 |
hda-11 | hda-10 | C35A5.9.1 | Y51H1A.5.1 | Hist_deacetyl domain-containing protein. | Hist_deacetyl domain-containing protein. | 0.621 |
hda-11 | hda-3 | C35A5.9.1 | R06C1.1.1 | Hist_deacetyl domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.519 |
hda-11 | hda-5 | C35A5.9.1 | F43G6.11.1 | Hist_deacetyl domain-containing protein. | Hist_deacetyl domain-containing protein. | 0.542 |
hda-3 | hda-10 | R06C1.1.1 | Y51H1A.5.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Hist_deacetyl domain-containing protein. | 0.749 |
hda-3 | hda-11 | R06C1.1.1 | C35A5.9.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Hist_deacetyl domain-containing protein. | 0.519 |
hda-3 | hda-5 | R06C1.1.1 | F43G6.11.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Hist_deacetyl domain-containing protein. | 0.633 |
hda-5 | hda-11 | F43G6.11.1 | C35A5.9.1 | Hist_deacetyl domain-containing protein. | Hist_deacetyl domain-containing protein. | 0.542 |
hda-5 | hda-3 | F43G6.11.1 | R06C1.1.1 | Hist_deacetyl domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.633 |
hop-1 | act-5 | C18E3.8.1 | T25C8.2.2 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | ACTin. | 0.484 |
hop-1 | sel-12 | C18E3.8.1 | F35H12.3.1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. | 0.923 |
hop-1 | spe-4 | C18E3.8.1 | ZK524.1.1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. | 0.928 |
hop-1 | sph-1 | C18E3.8.1 | F42G8.11.1 | Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. | MARVEL domain-containing protein. | 0.756 |