(5 nodes) (2009) The FEAR network. network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	zen-4	Kinesin-like protein. (787 aa)
	ZK430.5	Peptidase C50 domain-containing protein. (1276 aa)
	cyb-2.2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (339 aa)
	sep-1	Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...] (1262 aa)
	cyb-2.1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (317 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ZK430.5	cyb-2.1	ZK430.5.1	Y43E12A.1.1	Peptidase C50 domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.979
ZK430.5	cyb-2.2	ZK430.5.1	H31G24.4.2	Peptidase C50 domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.979
ZK430.5	zen-4	ZK430.5.1	M03D4.1d.2	Peptidase C50 domain-containing protein.	Kinesin-like protein.	0.729
cyb-2.1	ZK430.5	Y43E12A.1.1	ZK430.5.1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Peptidase C50 domain-containing protein.	0.979
cyb-2.1	cyb-2.2	Y43E12A.1.1	H31G24.4.2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.946
cyb-2.1	sep-1	Y43E12A.1.1	Y47G6A.12.2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...]	0.981
cyb-2.1	zen-4	Y43E12A.1.1	M03D4.1d.2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Kinesin-like protein.	0.855
cyb-2.2	ZK430.5	H31G24.4.2	ZK430.5.1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Peptidase C50 domain-containing protein.	0.979
cyb-2.2	cyb-2.1	H31G24.4.2	Y43E12A.1.1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.946
cyb-2.2	sep-1	H31G24.4.2	Y47G6A.12.2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...]	0.981
cyb-2.2	zen-4	H31G24.4.2	M03D4.1d.2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	Kinesin-like protein.	0.850
sep-1	cyb-2.1	Y47G6A.12.2	Y43E12A.1.1	Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...]	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.981
sep-1	cyb-2.2	Y47G6A.12.2	H31G24.4.2	Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...]	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.981
sep-1	zen-4	Y47G6A.12.2	M03D4.1d.2	Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...]	Kinesin-like protein.	0.793
zen-4	ZK430.5	M03D4.1d.2	ZK430.5.1	Kinesin-like protein.	Peptidase C50 domain-containing protein.	0.729
zen-4	cyb-2.1	M03D4.1d.2	Y43E12A.1.1	Kinesin-like protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.855
zen-4	cyb-2.2	M03D4.1d.2	H31G24.4.2	Kinesin-like protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.850
zen-4	sep-1	M03D4.1d.2	Y47G6A.12.2	Kinesin-like protein.	Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...]	0.793